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Active Recombinant Cynomolgus IL5 Protein (Met1-Ser134), His-tagged

Cat.No. : IL5-998C
Product Overview : Recombinant Cynomolgus IL5 Protein (Met1-Ser134) was produced by Baculovirus-Insect Cells expression system. This protein was expressed with a polyhistidine tag at the C-terminus.
  • Specification
  • Gene Information
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Description : Interleukin 5 (IL-5) is a member of the interleukin family with length of 115 amino acids. Interleukins are a group of cytokines (secreted proteins / signaling molecules) that were first seen to be expressed by white blood cells (leukocytes) and has been found in a wide variety of body cells. Interleukin 5 or IL-5 is produced by T helper-2 cells and mast cells. It helps to stimulate B cell growth and increase immunoglobulin secretion and is considered as a key mediator in eosinophil activation. Interleukin 5 (IL-5) has long been associated with several allergic diseases, including allergic rhinitis and asthma. Growth in the number of circulating, airway tissue, and induced sputum eosinophils have been observed in patients with these diseases. IL-5 also had something with the terminally differentiated granulocyte eosinophils. IL-5 was originally found as an eosinophil colony stimulating factor. It has been proved to be a major regulator of eosinophil accumulation in tissues, and can modulate eosinophil behavior at every stage from maturation to survival.
Source : Baculovirus-Insect Cells
Species : Cynomolgus
Tag : His
Predicted N Terminal : Ile 20
Form : Lyophilized from sterile 50mM Tris, pH 8.0,150mM NaCl,10% glycerol. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Bio-activity : Measured in a cell proliferation assay using TF-1 human erythroleukemic cells.
The EC50 for this effect is typically 0.5-2ng/ml.
Molecular Mass : The recombinant IL5 consists of 126 amino acids and predicts a molecular mass of 14.6 kDa.
Protein length : Met1-Ser134
Endotoxin : < 1.0 EU per μg protein as determined by the LAL method.
Purity : > 95 % as determined by SDS-PAGE.
Stability : Samples are stable for up to twelve months from date of receipt at -70 centigrade.
Storage : Store it under sterile conditions at -20 centigrade to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 mg/ml. Centrifuge the vial at 4℃ before opening to recover the entire contents.
Shipping : In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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Which effect of IL5 in the treatment of tuberous sclerosis? 08/07/2022

Inhibit the creatinine kinase level in the blood of patients with tuberous sclerosis, reduce the inflammatory response, and improve the quality of life of patients.

Does there have any effect of IL5 in the treatment of allergic rhinitis? 07/07/2022

IL5 can reduce the number of eosinophils in the nasal mucosa of patients with allergic rhinitis, reducing the symptoms of allergic reactions, such as sneezing, runny nose and nasal congestion.

What is the main function of IL5? 03/04/2022

Stimulate the proliferation and differentiation of white blood cells, promote the function of the immune system, and is used to treat diseases such as asthma, allergic rhinitis, nodular sclerosis and some malignant tumors.

Does IL5 have side effects? 10/26/2019

Cause mild side effects such as headache, nausea, vomiting, and serious side effects such as allergic reactions if the dose is too large or allergic.

Can IL5 be administered orally? 07/24/2019

IL5 cannot be administered orally, only by injection or intravenous drip.

What is the effect of IL5 in the treatment of asthma? 02/14/2019

IL5 can reduce the number of eosinophils in the lungs of asthma patients, reduce the frequency and severity of asthma attacks, and improve the quality of life of patients.

Customer Reviews (3)

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Reviews
07/26/2022

    High efficacy and safety in clinical treatment.

    06/22/2022

      There are no structural or functional defects.

      01/31/2019

        The stability and activity are maintained well during long-term storage.

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