|Official Full Name||interleukin 5|
|Background||This gene encodes a cytokine that acts as a growth and differentiation factor for both B cells and eosinophils. The encoded cytokine plays a major role in the regulation of eosinophil formation, maturation, recruitment and survival. The increased production of this cytokine may be related to pathogenesis of eosinophil-dependent inflammatory diseases. This cytokine functions by binding to its receptor, which is a heterodimer, whose beta subunit is shared with the receptors for interleukine 3 (IL3) and colony stimulating factor 2 (CSF2/GM-CSF). This gene is located on chromosome 5 within a cytokine gene cluster which includes interleukin 4 (IL4), interleukin 13 (IL13), and CSF2 . This gene, IL4, and IL13 may be regulated coordinately by long-range regulatory elements spread over 120 kilobases on chromosome 5q31.|
|Synonyms||EDF; TRF; IL-5; B Cell Differentiation Factor I; B-cell differentiation factor I; Colony stimulating factor; Colony Stimulating Factor Eosinophil; Eosinophil; Eosinophil Differentiation Factor; IL 5; IL5; IL5_HUMAN; Interleukin 5 (colony stimulating factor, eosinophil); Interleukin 5; Interleukin-5; Interleukin5; T Cell Replacing Factor; T-cell replacing factor;|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
Il5 involved in several pathways and played different roles in them. We selected most pathways Il5 participated on our site, such as Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, Hematopoietic cell lineage, which may be useful for your reference. Also, other proteins which involved in the same pathway with Il5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Cytokine-cytokine receptor interaction||CCL3; PDGFA; VEGFA; IL-15RA; IFNW1; IFNAR2; TNFRSF4; IL13RA1; Ccl27a; CXCL2|
|Jak-STAT signaling pathway||PTPN11B; STAT6; Ifna15; IL22; STAT3; GM-CSF; IFNK; IFNA12; FHL1A; IL27RA|
|Hematopoietic cell lineage||ITGA1; GP1BB; HLA-DRB1; CD1E; IL1R2; GP9; CD3E; CD7; GM2002; CSF3|
|T cell receptor signaling pathway||AKT1; NFATC2; NFATC3; GRAP2; MAPK3; DBNLB; PAK7; PDCD1; NFKB1; PIK3CB|
|Fc epsilon RI signaling pathway||MAP2K4; MAP2K2; GRB2; PLA2G4D; TNF; MAPK3; SYK; PIK3CB; NRAS; MAPK13|
|Intestinal i||ICOS; HLA-DRB4; Il2; CXCL12A; CD86; CCR9A; BMA2; CXCR4; CCL27B; HLA-DQB1|
|ne network for IgA production||MHC2DEB; CCL27B; AICDA; CD28; CCR10; Icosl; HLA-DOA; CD80; ICOSLG; HLA-DPA1|
|Asthma||HLA-DPA1; TNF; HLA-DQA2; H2-AA; CCL11; IL3; RNASE3; IL4; HLA-DQB1; HLA-DMB|
|Autoi||TSHR; TG; CD40LG; HLA-DRB4; Ifna15; IL5; IFNA17; PRF1; H2-AB1; IFNA16|
|ne thyroid disease||Ifna11; CD40LG; HLA-DPB1; GZMB; IFNA12; IFNA8; HLA-E; HLA-DRB5; HLA-DMB; FASLG|
|Inflammatory bowel disease (IBD)||IL12RB1; TGFB3; IL5; IL12B; HLA-DMB; IL13; IL18R1; TNF; HLA-DRB3; RORC|
|Allograft rejection||CD40; Il2; HLA-DRB5; HLA-A; H2-AA; HLA-E; HLA-DMB; FAS; MICA; HLA-DMA|
Il5 has several biochemical functions, for example, cytokine activity, growth factor activity, interleukin-5 receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Il5 itself. We selected most functions Il5 had, and list some proteins which have the same functions with Il5. You can find most of the proteins on our site.
|cytokine activity||LFT2; IL24; IL31; TNFSF18; FAM3D; CCL20B; GREM1; GM13288; IL3; IL5|
|growth factor activity||F2; IGF2B; MSTN; CNTF; FGF10A; NDR2; GDF7; CSPG5; GDF11; IGF2A|
|interleukin-5 receptor binding||IL5; SDCBP|
|protein binding||CTNNA2; CMTM3; KRTAP2-3; CDR2; FGFR1B; ELK4; PSMF1; MOBKL1A; FBXW9; ERCC4|
Il5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Il5 here. Most of them are supplied by our site. Hope this information will be useful for your research of Il5.