Il5

  • Official Full Name

    interleukin 5

  • Overview

    This gene encodes a cytokine that acts as a growth and differentiation factor for both B cells and eosinophils. The encoded cytokine plays a major role in the regulation of eosinophil formation, maturation, recruitment and survival. The increased production of this cytokine may be related to pathogenesis of eosinophil-dependent inflammatory diseases. This cytokine functions by binding to its receptor, which is a heterodimer, whose beta subunit is shared with the receptors for interleukine 3 (IL3) and colony stimulating factor 2 (CSF2/GM-CSF). This gene is located on chromosome 5 within a cytokine gene cluster which includes interleukin 4 (IL4), interleukin 13 (IL13), and CSF2 . This gene, IL4, and IL13 may be regulated coordinately by long-range regulatory elements spread over 120 kilobases on chromosome 5q31.
  • Synonyms

    EDF; TRF; IL-5; B Cell Differentiation Factor I; B-cell differentiation factor I; Colony stimulating factor; Colony Stimulating Factor Eosinophil; Eosinophil; Eosinophil Differentiation Factor; IL 5; IL5; IL5_HUMAN; Interleukin 5 (colony stimulating factor, eosinophil); Interleukin 5; Interleukin-5; Interleukin5; T Cell Replacing Factor; T-cell replacing factor;

  • Recombinant Proteins
  • Transfected Stable Cell Lines
  • Antibody
  • GMP Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Canine
  • Cattle
  • Chicken
  • Cynomolgus
  • Dog
  • Equine
  • Feline
  • Ferret
  • Horse
  • Human
  • Mouse
  • Pig
  • Rabbit
  • Rat
  • Rhesus
  • Rhesus Macaque
  • Rhesus monkey
  • CHO
  • E.coli
  • HEK293
  • HEK293 cells
  • HEK293F
  • Hordeum Vulgare
  • Human Cell
  • In Vitro Cell Free System
  • Insect cell
  • Insect Cell
  • Insect cells
  • Insect Cells
  • Mammalian Cell
  • Mammalian cells
  • Mouse
  • Rat
  • Sf21 Insect Cell
  • Wheat Germ
  • Yeast
  • C
  • His
  • Fc|His
  • GST
  • His (Fc)
  • Avi
  • His(C
  • ter)
  • His|GST
  • His|T7
  • LEAF
  • mFc
  • N/A
  • N
  • Strep II
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human IL5-99H Active Recombinant Human IL5 CHO N/A
Human IL5-8864H Active Recombinant Human IL5,His-tagged Hordeum Vulgare N/A
Human IL5-01H Active Recombinant Human IL5 Protein, His-Tagged Insect Cell His 124aa
Human IL5-61H Recombinant Human IL5 protein E.coli N/A 116
Human IL5-185H Recombinant Human IL5, His tagged E.coli Fc/His
Human IL5-312H Active Recombinant Human IL5 protein(Ile20-Ser134) E.coli N/A Ile20-Ser134
Human IL5-269H Recombinant Human IL5, StrepII-tagged Human Cell Strep II 20-134, 115 a.a.
Human IL5-126H Recombinant Human IL5 protein, His-tagged HEK293 His Ile20-Ser134
Human IL5-502H Recombinant Human IL5 protein(Met1-Ser134), His-tagged HEK293 C-His Met1-Ser134
Human IL5-528H Recombinant Human Interleukin 5 (Colony-Stimulating Factor, Eosinophil) E.coli N/A
Human IL5-27607TH Recombinant Human IL5 protein, His-tagged HEK293 His Ile20-Ser134
Human IL5-125H Recombinant Human IL5 HEK293 N/A
Human IL5-1240H Recombinant Human Interleukin 5 E.coli N/A
Human IL5-214H Recombinant Human IL5 Sf21 Insect Cell N/A
Human IL5-144H Recombinant Human IL5 protein E.coli N/A
Human IL5-651H Recombinant Human IL5 protein, His & T7-tagged E.coli His/T7 Ile20~Ser134 (Accession # P05113)
Human IL5-103H Human Interleukin-5(rDNA derived) Reference standard N/A
Human DMABT-H19267 Rat Anti-IL5 Monoclonal Antibody Rat LEAF
Human IL5-4321HG GMP Recombinant Human IL5 protein HEK293 DNA sequence encoding Human IL-5(UniProtKB/Swiss-Prot: P05113) was expressed with His tag at the C-terminal.
Human IL5-5178H Recombinant Human IL5 Protein, GST-tagged Wheat Germ GST
Human IL5-4320HG Active GMP Recombinant Human IL5 protein E.coli N/A
Human IL5-5450H Recombinant Human IL5 protein, His-tagged Yeast His 20-134aa
Human IL5-127H Recombinant Human IL5(Ile20-Ser134) Protein, C-mFc-tagged HEK293 mFc
Human IL5-051HB Recombinant Human IL5 protein, His-Avi-tagged, Biotinylated HEK293 His-Avi Ile20-Ser134
Human IL5-43H Recombinant Human IL5 Protein E.coli
Human IL5-182H Active Recombinant Human IL5 Protein E.coli
Human IL5-206H Recombinant Active Human IL5 Protein, His-tagged(C-ter) E.coli His(C-ter)
Human IL5-354I Active Recombinant Human IL5 Protein (116 aa) E.coli 116
Human IL5-5685HF Recombinant Full Length Human IL5 Protein, GST-tagged In Vitro Cell Free System GST 134 amino acids
Human IL5-0295H Active Recombinant Human IL5 protein HEK293 N/A Ile20-Ser134
Human IL5-240I Active Recombinant Human IL5 Protein CHO
Human IL5-2575H Recombinant Human IL5 Protein (Ile20-Ser134), N-His tagged E.coli N-His Ile20-Ser134
Human IL5-76H Recombinant Human IL5 Protein, His-tagged Human Cell His
Human IL5-2574H Recombinant Human IL5 Protein (Ile20-Ser134), C-His tagged Mammalian cells C-His Ile20-Ser134
Human IL5-0018H Recombinant Human IL5 Protein HEK293 cells
Human IL5-169H Active Recombinant Human IL5 Protein (Ile20-Ser134), C-His tagged, Animal-free, Carrier-free E.coli C-His Ile20-Ser134
Mouse IL5-412M Active Recombinant Mouse Interleukin-5 Mouse N/A
Mouse Il5-121M Active Recombinant Mouse Il5 CHO N/A
Mouse Il5-01M Active Recombinant Mouse Il5 Protein, His-Tagged E.coli His
Mouse Il5-110M Active Recombinant Mouse Il5(Met21-Gly133) Protein, C-6*His-tagged HEK293 His
Mouse Il5-755M Recombinant Mouse Il5 protein(Met1-Gly133), His-tagged Insect Cells C-His Met1-Gly133
Mouse Il5-206M Recombinant Mouse Il5 protein E.coli N/A 113
Mouse Il5-224M Recombinant Mouse Interleukin 5 Sf21 Insect Cell N/A
Mouse IL5-496MCL Recombinant Mouse IL5 cell lysate Insect Cell N/A
Mouse Il5-1043M Recombinant Mouse Il5 Protein, His-tagged HEK293F N-His Ala20-Gly133
Mouse Il5-4056M Recombinant Mouse Il5 Protein (Met21-Gly133), N-His tagged E.coli N-His Met21-Gly133
Mouse Il5-07M Active Recombinant Mouse Il5 Protein, His-tagged HEK293 His 21-133aa
Mouse Il5-112M Active Recombinant Mouse Il5 Protein E.coli
Mouse Il5-2096M Recombinant Mouse Il5 Protein E.coli N/A
Mouse IL5-183M Active Recombinant Mouse IL5 Protein E.coli
Mouse Il5-111M Active Recombinant Mouse Il5 Protein Insect Cell
Mouse Il5-08M Active Recombinant Mouse Il5 Protein, His-tagged Insect cell His 21-133aa
Mouse Il5-2097M Recombinant Mouse Il5 Protein Insect Cell N/A
Mouse Il5-353I Active Recombinant Mouse Il5 Protein (113 aa) E.coli 113
Mouse Il5-60M Active Recombinant Mouse Il5 Protein (Met21-Gly133), C-His tagged, Animal-free, Carrier-free E.coli C-His Met21-Gly133
Mouse Il5-1680M Recombinant Mouse Il5 Protein, His-tagged E.coli N-His Ala20-Gly133
Mouse Il5-207M Recombinant Active Mouse IL5 Protein, His-tagged(C-ter) E.coli His(C-ter)
Mouse Il5-239I Active Recombinant Mouse Il5 Protein CHO
Rat Il5-97R Recombinant Rat Interleukin 5 E.coli N/A
Rat Il5-1681R Recombinant Rat Il5 Protein, His-tagged E.coli N-His Met1-Val132
Rat Il5-238I Active Recombinant Rat Il5 Protein CHO
Rat Il5-2095R Recombinant Rat Il5 protein E.coli N/A 113
Rat Il5-352I Active Recombinant Rat Il5 Protein (113 aa) E.coli 113
Rhesus monkey IL5-653R Recombinant Rhesus monkey IL5 protein, His & GST-tagged E.coli His/GST Ile20~Ser134 (Accession # P48093)
Rabbit IL5-4361R Recombinant Rabbit IL5 Protein Yeast N/A 115aa
Rabbit IL5-1914R Active Recombinant Rabbit IL5 protein, His-tagged HEK293 His Met 20 - Ser 134
Rabbit IL5-2323R Recombinant Rabbit IL5 Protein, His-tagged E.coli N-His Met20-Ser134
Dog IL5-650D Recombinant Dog IL5 protein, His & T7-tagged E.coli His/T7 Phe20~Ser134 (Accession# Q95J76)
Dog IL5-003D Active Recombinant Dog IL5 Protein, His-tagged Insect cells His
Canine IL5-27C Recombinant Canine IL-5 Yeast N/A
Canine IL5-456CCL Recombinant Canine IL5 cell lysate Insect Cell N/A
Canine IL5-2177C Active Recombinant Canine IL5 Protein, His-tagged Insect Cell His
Canine IL5-456C Active Recombinant Canine IL5 Protein, His-tagged Insect Cell His Met1-Ser134
Cattle IL5-2322C Recombinant Cattle IL5 Protein, His-tagged E.coli N-His Val22-Ser134
Cynomolgus IL5-2176C Active Recombinant Cynomolgus IL5 protein(Ile 20 - Ser 134), His-tagged HEK293 N-His Ile 20 - Ser 134
Cynomolgus IL5-998C Active Recombinant Cynomolgus IL5 Protein (Met1-Ser134), His-tagged Insect Cell His Met1-Ser134
Equine IL5-901E Active Recombinant Equine IL5 Protein, His-tagged Mammalian cells His Leu20-Gly134
Equine IL5-257E Recombinant Equine Interleukin 5 (Colony-Stimulating Factor, Eosinophil) Yeast N/A
Equine IL5-1E Recombinant Equine IL5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Equine IL5-1E-B Recombinant Equine IL5 Protein Pre-coupled Magnetic Beads HEK293
Feline IL5-1048F Active Recombinant Feline IL5 Protein, His-tagged Mammalian cells His Ile20-Ser134
Feline IL5-6F-B Recombinant Feline IL5 Protein Pre-coupled Magnetic Beads HEK293
Feline IL5-4331F Recombinant Feline IL5 Protein Yeast N/A 115aa
Feline IL5-6F Recombinant Feline IL5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Ferret IL5-012F Recombinant Ferret IL5 Protein, Met1-Ser132, C-His tagged HEK293 C-His Met1-Ser132
Horse IL5-1042H Recombinant Horse IL5 Protein, His&GST-tagged E.coli N-His&GST Leu20-Gly134
Rhesus IL5-963R Recombinant Rhesus IL5 protein E.coli N/A 115
Rhesus Macaque IL5-2253R Recombinant Rhesus monkey IL5 Protein, His-tagged Mammalian Cell His
Rhesus Macaque IL5-2074R Recombinant Rhesus Macaque IL5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque IL5-2074R-B Recombinant Rhesus Macaque IL5 Protein Pre-coupled Magnetic Beads HEK293
Pig IL5-652P Recombinant Pig IL5 protein, His & T7-tagged E.coli His/T7 Ile20~Ser134 (Accession # Q9MYM5)
Pig IL5-4784P Recombinant Pig IL5 protein, His-tagged E.coli His 22-134aa
Pig IL5-5813P Recombinant Pig IL5 protein, His-tagged Yeast His 22-134aa
Chicken IL5-1735C Recombinant Chicken IL5 Mammalian Cell His
Chicken IL5-1044C Recombinant Chicken IL5 Protein, His-tagged E.coli N-His Thr17-Val136
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

Il5 involved in several pathways and played different roles in them. We selected most pathways Il5 participated on our site, such as Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, Hematopoietic cell lineage, which may be useful for your reference. Also, other proteins which involved in the same pathway with Il5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cytokine-cytokine receptor interactionEPO;IL23R;PRP2;IFNA2;IL17RB;IL18R1;BMPR1B;IL23;VEGFAA
Jak-STAT signaling pathwayPIM1;IFNA21;IFNGR2;PTPN11;IL24;IL19;PIK3CA;Ifnl2;IFNA5
Hematopoietic cell lineageIL7;Itgam&Itgb2;CD44;IL1B;HLA-DRB4;CD38;CD1E, B2M;TNF;CD2
T cell receptor signaling pathwayPIK3R3;MAPK3;RELA;CBLB;FOS;NCK2;PIK3CB;TEC;PPP3CA
Fc epsilon RI signaling pathwayMAP2K2;NRAS;PIK3CA;PRKCA;MAP2K1;PIK3CD;GAB2;PIK3R5;MAPK11
Intestinal iHLA-DOB;AICDA;CD40;HLA-DRB5;CD86;MAP3K14;CCL28;IL15;HLA-DPA1
ne network for IgA productionHLA-DMA;TGFB1A;CCL28;CXCL12A;ITGA4;IL6;MHC2DCB;PIGR;IL15
AsthmaHLA-DOB;HLA-DMB;HLA-DQA2;HLA-DPB1;CD40LG;FCER1A;HLA-DRA;HLA-DPA1;HLA-DRB4
AutoiH2-Q10;CD40LG;Ifna11;HLA-DRB1;HLA-DQB1;IFNA5;IL4;CD86;HLA-DQA2
ne thyroid diseaseH2-AA;IFNA10;HLA-C;IFNA8;FASLG;HLA-G;HLA-DRA;HLA-E;CD80
Inflammatory bowel disease (IBD)TNF;IL17A;STAT4;TGFB2;IL12B;TLR4;HLA-DPB1;TGFB1;TBX21
Allograft rejectionIL5;FAS;H2-AB1;CD40LG;HLA-DQA2;HLA-DRB4;CD86;HLA-A;HLA-DMA

Il5 has several biochemical functions, for example, cytokine activity, growth factor activity, interleukin-5 receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Il5 itself. We selected most functions Il5 had, and list some proteins which have the same functions with Il5. You can find most of the proteins on our site.

Function Related Protein
cytokine activityCCL38A.5;BMP4;TNFSF11;SPP1;BMP10;IFNA17;TGFB1;IL1A;TNF
growth factor activityEGF;CLCF1;IGF2A;GMFG;IL9;HBEGFA;INHBE;BMP2;GPI
interleukin-5 receptor bindingSDCBP;IL5
protein bindingKAT2A;PPP1R9B;C2orf63;RUFY1;TUBB;ADRB3;KRT17;JAG1;ZNF511

Il5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Il5 here. Most of them are supplied by our site. Hope this information will be useful for your research of Il5.

CSF2RB; IL5RA

Gene Family

IL

Research Area

Related articles

Hemmerle, T; Zgraggen, S; et al. Antibody-mediated delivery of interleukin 4 to the neo-vasculature reduces chronic skin inflammation. JOURNAL OF DERMATOLOGICAL SCIENCE 76:96-103(2014).
Hou, S; Landego, I; et al. Follicular dendritic cell secreted protein FDC-SP controls IgA production. MUCOSAL IMMUNOLOGY 7:948-957(2014).
  • Reviews
  • Q&As

Customer Reviews (3)

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Reviews
07/26/2022

    High efficacy and safety in clinical treatment.

    06/22/2022

      There are no structural or functional defects.

      01/31/2019

        The stability and activity are maintained well during long-term storage.

        Q&As (6)

        Ask a question
        Which effect of IL5 in the treatment of tuberous sclerosis? 08/07/2022

        Inhibit the creatinine kinase level in the blood of patients with tuberous sclerosis, reduce the inflammatory response, and improve the quality of life of patients.

        Does there have any effect of IL5 in the treatment of allergic rhinitis? 07/07/2022

        IL5 can reduce the number of eosinophils in the nasal mucosa of patients with allergic rhinitis, reducing the symptoms of allergic reactions, such as sneezing, runny nose and nasal congestion.

        What is the main function of IL5? 03/04/2022

        Stimulate the proliferation and differentiation of white blood cells, promote the function of the immune system, and is used to treat diseases such as asthma, allergic rhinitis, nodular sclerosis and some malignant tumors.

        Does IL5 have side effects? 10/26/2019

        Cause mild side effects such as headache, nausea, vomiting, and serious side effects such as allergic reactions if the dose is too large or allergic.

        Can IL5 be administered orally? 07/24/2019

        IL5 cannot be administered orally, only by injection or intravenous drip.

        What is the effect of IL5 in the treatment of asthma? 02/14/2019

        IL5 can reduce the number of eosinophils in the lungs of asthma patients, reduce the frequency and severity of asthma attacks, and improve the quality of life of patients.

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