Il5 Protein


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Official Full Name interleukin 5
Background This gene encodes a cytokine that acts as a growth and differentiation factor for both B cells and eosinophils. The encoded cytokine plays a major role in the regulation of eosinophil formation, maturation, recruitment and survival. The increased production of this cytokine may be related to pathogenesis of eosinophil-dependent inflammatory diseases. This cytokine functions by binding to its receptor, which is a heterodimer, whose beta subunit is shared with the receptors for interleukine 3 (IL3) and colony stimulating factor 2 (CSF2/GM-CSF). This gene is located on chromosome 5 within a cytokine gene cluster which includes interleukin 4 (IL4), interleukin 13 (IL13), and CSF2 . This gene, IL4, and IL13 may be regulated coordinately by long-range regulatory elements spread over 120 kilobases on chromosome 5q31.
Synonyms EDF; TRF; IL-5; B Cell Differentiation Factor I; B-cell differentiation factor I; Colony stimulating factor; Colony Stimulating Factor Eosinophil; Eosinophil; Eosinophil Differentiation Factor; IL 5; IL5; IL5_HUMAN; Interleukin 5 (colony stimulating factor, eosinophil); Interleukin 5; Interleukin-5; Interleukin5; T Cell Replacing Factor; T-cell replacing factor;
    • Species :
    • Canine
    • Cattle
    • Chicken
    • Cynomolgus
    • Dog
    • Equine
    • Feline
    • Horse
    • Human
    • Mouse
    • Pig
    • Rabbit
    • Rat
    • Rhesus
    • Rhesus Macaque
    • Rhesus monkey
    • Source :
    • CHO
    • E.coli
    • HEK293
    • HEK293F
    • Hordeum Vulgare
    • Human Cell
    • Insect Cell
    • Insect cells
    • Mammalian Cell
    • Mammalian cells
    • Mouse
    • Rat
    • Sf21 Insect Cell
    • Wheat Germ
    • Yeast
    • Tag :
    • Fc
    • His
    • GST
    • T7
    • His-Avi
    • LEAF
    • mFc
    • N/A
    • N-His
    • N-His&GST
    • Strep II
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human IL5-1240H Recombinant Human Interleukin 5 E.coli N/A
    Human IL5-125H Recombinant Human IL5 HEK293 N/A
    Human IL5-126H Recombinant Human IL5 protein, His-tagged HEK293 His
    Human IL5-144H Recombinant Human IL5 protein E.coli N/A
    Human IL5-185H Recombinant Human IL5, His tagged E.coli Fc/His
    Human IL5-214H Recombinant Human IL5 Sf21 Insect Cell N/A
    Human IL5-269H Recombinant Human IL5, StrepII-tagged Human Cell Strep II
    Human IL5-27607TH Recombinant Human IL5 protein, His-tagged HEK293 His
    Human IL5-312H Recombinant Human IL5 E.coli N/A
    Human IL5-502H Recombinant Human IL5 protein, His-tagged HEK293F His
    Human IL5-528H Recombinant Human Interleukin 5 (Colony-Stimulating Factor, Eosinophil) E.coli N/A
    Human IL5-61H Recombinant Human IL5 protein E.coli N/A
    Human IL5-651H Recombinant Human IL5 protein, His & T7-tagged E.coli His/T7
    Human IL5-8864H Recombinant Human IL5,His-tagged Hordeum Vulgare N/A
    Human IL5-99H Recombinant Human IL5 CHO N/A
    Mouse Il5-121M Recombinant Mouse Il5 CHO N/A
    Mouse Il5-206M Recombinant Mouse Il5 protein E.coli N/A
    Mouse Il5-224M Recombinant Mouse Interleukin 5 Sf21 Insect Cell N/A
    Mouse IL5-412M Recombinant Mouse Interleukin-5 Mouse N/A
    Mouse Il5-755M Recombinant Mouse Il5, His tagged Insect Cell His
    Rat Il5-97R Recombinant Rat Interleukin 5 E.coli N/A
    Rhesus Macaque IL5-2253R Recombinant Rhesus monkey IL5 Protein, His-tagged Mammalian Cell His
    Rhesus monkey IL5-653R Recombinant Rhesus monkey IL5 protein, His & GST-tagged E.coli His/GST
    Rhesus IL5-963R Recombinant Rhesus IL5 protein E.coli N/A
    Canine IL5-27C Recombinant Canine IL-5 Yeast N/A
    Dog IL5-650D Recombinant Dog IL5 protein, His & T7-tagged E.coli His/T7
    Chicken IL5-1735C Recombinant Chicken IL5 Mammalian Cell His
    Feline IL5-1048F Recombinant Feline IL5 Protein, His-tagged Mammalian cells His
    Equine IL5-257E Recombinant Equine Interleukin 5 (Colony-Stimulating Factor, Eosinophil) Yeast N/A
    Pig IL5-652P Recombinant Pig IL5 protein, His & T7-tagged E.coli His/T7
    Equine IL5-901E Recombinant Equine IL5 Protein, His-tagged Mammalian cells His
    Mouse IL5-496MCL Recombinant Mouse IL5 cell lysate Insect Cell N/A
    Canine IL5-456CCL Recombinant Canine IL5 cell lysate Insect Cell N/A
    Mouse Il5-07M Recombinant Mouse Il5 Protein, His-tagged HEK293 His
    Mouse Il5-08M Recombinant Mouse Il5 Protein, His-tagged Insect cell His
    Horse IL5-1042H Recombinant Horse IL5 Protein, His&GST-tagged E.coli N-His&GST
    Mouse Il5-1043M Recombinant Mouse Il5 Protein, His-tagged HEK293F N-His
    Chicken IL5-1044C Recombinant Chicken IL5 Protein, His-tagged E.coli N-His
    Mouse Il5-110M Recombinant Mouse Il5(Met21-Gly133) Protein, C-6*His-tagged HEK293 His
    Human IL5-127H Recombinant Human IL5(Ile20-Ser134) Protein, C-mFc-tagged HEK293 mFc
    Mouse Il5-1680M Recombinant Mouse Il5 Protein, His-tagged E.coli N-His
    Rat Il5-1681R Recombinant Rat Il5 Protein, His-tagged E.coli N-His
    Cattle IL5-2322C Recombinant Cattle IL5 Protein, His-tagged E.coli N-His
    Rabbit IL5-2323R Recombinant Rabbit IL5 Protein, His-tagged E.coli N-His
    Human IL5-43H Recombinant Human IL5 Protein E.coli
    Pig IL5-4784P Recombinant Pig IL5 protein, His-tagged E.coli His
    Human IL5-5450H Recombinant Human IL5 protein, His-tagged Yeast His
    Pig IL5-5813P Recombinant Pig IL5 protein, His-tagged Yeast His
    Human DMABT-H19267 Rat Anti-IL5 Monoclonal Antibody Rat LEAF
    Human IL5-051HB Recombinant Human IL5 protein, His-Avi-tagged, Biotinylated HEK293 His-Avi
    Human IL5-103H Human Interleukin-5(rDNA derived) Reference standard N/A
    Human IL5-4320HG GMP Recombinant Human IL5 protein E.coli N/A
    Human IL5-4321HG GMP Recombinant Human IL5 protein, His-tagged HEK293 His
    Human IL5-5178H Recombinant Human IL5 Protein, GST-tagged Wheat Germ GST
    Mouse Il5-111M Recombinant Mouse Il5 Protein Insect Cell
    Mouse Il5-112M Recombinant Mouse Il5 Protein E.coli
    Mouse Il5-2096M Recombinant Mouse Il5 Protein E.coli N/A
    Mouse Il5-2097M Recombinant Mouse Il5 Protein Insect Cell N/A
    Rat Il5-2095R Recombinant Rat Il5 protein E.coli N/A
    Cynomolgus IL5-998C Recombinant Cynomolgus IL5 Protein (Met1-Ser134), His-tagged Insect Cell His
    Dog IL5-003D Recombinant Dog IL5 Protein, His-tagged Insect cells His
    Canine IL5-2177C Recombinant Canine IL5 Protein, His-tagged Insect Cell His
    Canine IL5-456C Recombinant Canine IL5 Protein, His-tagged Insect Cell His
    Rabbit IL5-4361R Recombinant Rabbit IL5 Protein Yeast N/A
    Feline IL5-4331F Recombinant Feline IL5 Protein Yeast N/A

    Il5 involved in several pathways and played different roles in them. We selected most pathways Il5 participated on our site, such as Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, Hematopoietic cell lineage, which may be useful for your reference. Also, other proteins which involved in the same pathway with Il5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cytokine-cytokine receptor interaction CD70; Ccl27a; CXCR6; CSF1RA; PPBP; INHBE; IFNB; IL18; CCL20B; IL17RA
    Jak-STAT signaling pathway IL22RA1; SOS1; STAT1; IFNGR2; JAK2A; Ifnl2; PRP2; GHR; IL28A; CTF1
    Hematopoietic cell lineage TFRC; ANPEP; Il6ra; FCER2; MS4A1; IL5; HLA-DRB1; CD1E, B2M; CD2; Fcer2a
    T cell receptor signaling pathway CD3E; CD3D; CD8A; DLG1; NRAS; VAV3; PIK3R3; CD4; CD3E; CABIN1; NFATC1
    Fc epsilon RI signaling pathway NRAS; FCER1G; PIK3CA; MAP2K2; MAPK1; FCER1A; MAP2K6; MAPK3; PLCG2; FYN
    Intestinal i Icosl; HLA-DOA; MHC2DAB; CCL27B; ITGA4; CCR9A; CCL25; HLA-DMB; CXCL12B; HLA-DRB1
    ne network for IgA production MHC2DEB; MHC2A; CCL25B; HLA-DRA; BLB2; MHC2DAB; MHC2DCB; CXCR4B; HLA-DRB3; HLA-DOB
    Autoi Fasl; HLA-DQA2; Il2; CD40LG; IFNA4; HLA-DRB3; IL5; GZMB; FAS; H2-Q10
    ne thyroid disease IL4; TG; IFNA12; HLA-G; HLA-E; IFNA5; IFNA16; IFNA8; HLA-DRB4; TPO
    Inflammatory bowel disease (IBD) TGFB1; HLA-DRB1; RORA; IL21R; STAT1; IL21; HLA-DRB5; IL23; HLA-DPB1; IL13
    Allograft rejection Fasl; H2-Q10; HLA-DRB3; HLA-DQB1; HLA-B; GZMB; IL10; HLA-DPA1; HLA-DRA; IL5

    Il5 has several biochemical functions, for example, cytokine activity, growth factor activity, interleukin-5 receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Il5 itself. We selected most functions Il5 had, and list some proteins which have the same functions with Il5. You can find most of the proteins on our site.

    Function Related Protein
    cytokine activity IFNA12; IL32; IFN-a; IL17A/F1; GDF6B; CMTM3; IFNPHI1; CMTM8; ADIPOQ; IL34
    growth factor activity NRG1; FGF20B; MDKA; IGF2; LFT1; MIA1; BMP15; MANF; FGF11; BMP8A
    interleukin-5 receptor binding SDCBP; IL5
    protein binding INO80B; IFIT3; TLR6; ZNF317; GTF3C5; ZNF843; C14orf93; APOOL; CD2BP2; DULLARD

    Il5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Il5 here. Most of them are supplied by our site. Hope this information will be useful for your research of Il5.


    Hemmerle, T; Zgraggen, S; et al. Antibody-mediated delivery of interleukin 4 to the neo-vasculature reduces chronic skin inflammation. JOURNAL OF DERMATOLOGICAL SCIENCE 76:96-103(2014).
    Hou, S; Landego, I; et al. Follicular dendritic cell secreted protein FDC-SP controls IgA production. MUCOSAL IMMUNOLOGY 7:948-957(2014).


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