Recombinant Full Length Human M6PR Protein, C-Flag-tagged

• Cat.No.: M6PR-838HFL
• Product Overview: Recombinant Full Length Human M6PR Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: This gene encodes a member of the P-type lectin family. P-type lectins play a critical role in lysosome function through the specific transport of mannose-6-phosphate-containing acid hydrolases from the Golgi complex to lysosomes. The encoded protein functions as a homodimer and requires divalent cations for ligand binding. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome X.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 27.9 kDa
• AA Sequence: MFPFYSCWRTGLLLLLLAVAVRESW QTEEKTCDLVGEKGKESEKELALVK RLKPLFNKSFESTVGQGSDT YIYIFRVCREAGNHTSGAGLVQINK SNGKETVVGRLNETHIFNGSNWIML IYKGGDEYDNHCGKEQRRAV VMISCNRHTLADNFNPVSEERGKVQ DCFYLFEMDSSLACSPEISHLSVGS ILLVTFASLVAVYVVGGFLY QRLVVGAKGMEQFPHLAFWQDLGNL VADGCDFVCRSKPRNVPAAYRGVGD DQLGEESEERDDHLLPMTRTRPLEQ KLISEEDLAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Lysosome

Gene Information

• Gene Name: M6PR mannose-6-phosphate receptor, cation dependent [ Homo sapiens (human) ]
• Official Symbol: M6PR
• Synonyms: SMPR; MPR46; CD-MPR; MPR 46; MPR-46; CD-M6PR
• Gene ID: 4074
• mRNA Refseq: NM_002355.4
• Protein Refseq: NP_002346.1
• MIM: 154540
• UniProt ID: P20645