Recombinant Human ACE2 Protein, Fc-Avi-Tagged, Biotinylated

• Cat.No.: ACE2-231H
• Product Overview: Biotinylated Human ACE2, Fc, Avitag is expressed from human 293 cells (HEK293). It contains AA Gln 18 - Ser 740 (Accession # Q9BYF1-1).

Specification

• Description: Angiotensin-converting enzyme 2 (ACE2) is also known as ACEH (ACE homolog), is an integral membrane protein with considerable homologous to ACE, which belongs to the peptidase M2 family. ACE2 is an exopeptidase that catalyses the conversion of angiotensin I to the nonapeptide angiotensin, or the conversion of angiotensin II to angiotensin 1-7. ACE2 may be an important regulator of heart function. In case of human coronaviruses SARS and HCoV-NL63 infections, ACE-2 serve as functional receptor for the spike glycoprotein of both coronaviruses. ACE2 is activated by chloride and fluoride, but not bromide and Inhibited by MLN-4760, cFP_Leu, and EDTA, but not by the ACE inhibitors linosipril, captopril and enalaprilat. ACE2 is active from pH 6 to 9, and the optimum pH is 6.5 in the presence of 1 M NaCl.
• Source: HEK293
• Species: Human
• Tag: Fc-Avi
• Predicted N Terminal: Gln 18
• Form: Delivered as bulk protein in a 0.2 μm filtered solution of 50 mM Tris, 150 mM NaCl, pH7.5 with glycerol as protectant.
• Molecular Mass: The protein has a calculated MW of 111.7 kDa. The protein migrates as 125-150 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
• Protein length: Gln 18 - Ser 740
• Endotoxin: Less than 1.0 EU per μg by the LAL method.
• Purity: >95% as determined by SDS-PAGE.
• Storage: Please avoid repeated freeze-thaw cycles.
  This product is stable after storage at:
  The product MUST be stored at -70°C or lower upon receipt;
  -70°C for 3 months under sterile conditions.
• Shipping: This product is supplied as sterile liquid solution and shipped frozen with dry ice, please inquire the shipping cost.

Gene Information

• Gene Name: ACE2 angiotensin I converting enzyme 2 [ Homo sapiens (human) ]
• Official Symbol: ACE2
• Synonyms: ACE-2; ACEH; ACE2
• Gene ID: 59272
• mRNA Refseq: NM_021804.3
• Protein Refseq: NP_068576.1
• MIM: 300335
• UniProt ID: Q9BYF1