ACE2

  • Official Full Name

    angiotensin I converting enzyme 2

  • Overview

    The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. The organ- and cell-specific expression of this gene suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. In addition, the encoded protein is a functional receptor for the spike glycoprotein of the human coronaviruses SARS and HCoV-NL63. [provided by RefSeq, Jul 2008]
  • Synonyms

    ACE2; angiotensin I converting enzyme 2; ACEH; angiotensin-converting enzyme 2; peptidyl-dipeptidase A; metalloprotease MPROT15; ACE-related carboxypeptidase; angiotensin-converting enzyme homolog; angiotensin I converting enzyme (peptidyl-dipeptidase A) 2;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chromatography Reagents
  • Assay Kits
  • Cynomolgus
  • Cynomolgus monkey
  • Cynomolgus Monkey
  • Dog
  • Human
  • Mink
  • Mouse
  • Paguma larvata
  • Rat
  • Rhesus
  • Rhesus Macaque
  • Rhesus monkey
  • SARS-CoV-2
  • Zebrafish
  • CHO
  • CHO cells
  • E.coli
  • HEK293
  • HEK293 cells
  • HEK293F
  • HEK293T
  • Human Cell
  • Human cells
  • Insect Cell
  • Insect Cells
  • Mammalian cell
  • Mammalian Cell
  • Mammalian cells
  • Nicotiana Benthamiana
  • Avi
  • His(C
  • ter)
  • C
  • His
  • Fc
  • hFc
  • mFc
  • DYKDDDDK
  • Fc(C
  • Flag
  • FLAG
  • GST
  • hIgG
  • His (Fc)
  • His(N
  • His\Avi
  • His|T7
  • Human IgG1 Fc(C
  • N/A
  • N
  • No tag
  • Tag Free
  • Tag
  • free
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ACE2-736H Active Recombinant Human ACE2 protein, His-tagged HEK293 His Gln18-Ser740
Human ACE2-68H Active Recombinant Human ACE2, Fc-tagged HEK293 Fc Met 1-Ser 740
Human ACE2-051H Active Recombinant Human ACE2 protein, His/Avi-tagged, Biotinylated CHO cells His/Avi Gln18 - Ser740
Human ACE2-052H Active Recombinant Human ACE2 protein, Fc/Avi-tagged, Biotinylated CHO cells Fc/Avi Gln18-Ser740
Human ACE2-736HA Active Recombinant Human ACE2, His-tagged, APC labeled HEK293 His
Human ACE2-817HB Active Recombinant Human ACE2 protein, mFc-Avi-tagged Mammalian cell mFc-Avi 18-740aa
Human ACE2-1082H Recombinant Human ACE2 protein(Met1-Ser740), His-tagged, Biotinylated HEK293 C-His Met1-Ser740
Human ACE2-3407H Active Recombinant Human ACE2 protein(Met1-Ser740), His-Avi-tagged, Biotinylated Insect Cells C-His-Avi Met1-Ser740
Human ACE2-185H Active Recombinant Human ACE2 protein, mFc-tagged HEK293 mFc Gln 18 - Ser 740
Human ACE2-67H Active Recombinant Human ACE2, FLAG-tagged HEK293 Flag
Human ACE2-239H Recombinant Human ACE2, Fc tagged Human Cell Fc
Human ACE2-745H Recombinant Human ACE2, His-tagged Mammalian cells His
Human ACE2-735H Recombinant Human ACE2 Protein, His-tagged HEK293T His
Human ACE2-3100HCL Recombinant Human ACE2 cell lysate Human Cell N/A
Human ACE2-091H Recombinant Human ACE2 Protein, Fc-tagged Human cells Fc
Human ACE2-009H Active Recombinant Human ACE2 protein, Fc-tagged Human Cell Fc
Human ACE2-031H Recombinant Human ACE2 Protein, Fc-tagged CHO Fc 18-615
Human ACE2-229H Recombinant Human ACE2 protein, His/Avi-tagged Mammalian cells His/Avi 723
Human ACE2-01H Recombinant Human ACE2 Protein (ECD), Avi-His-tagged(C-ter) HEK293 Avi-His(C-ter) Gln18-Ser740
Human ACE2-230H Recombinant Human ACE2 Protein, His-Avi-Tagged, Biotinylated HEK293 His-Avi Gln 18 - Ser 740
Human ACE2-231H Recombinant Human ACE2 Protein, Fc-Avi-Tagged, Biotinylated HEK293 Fc-Avi Gln 18 - Ser 740
Human ACE2-092H Recombinant Human ACE2 (Gln18-Ser740) Protein, Fc-tagged Human cells Fc
Human ACE2-03H Recombinant Human ACE2 Protein (ECD), His-tagged(N-ter) HEK293 His(N-ter) Gln18-Ser740
Human ACE2-604H Active Recombinant Human ACE2 Protein, Fc-tagged CHO Fc 18-615
Human ACE2-02H Recombinant Human ACE2 Protein (ECD), Fc-tagged(C-ter) HEK293 Fc(C-ter) Gln18-Ser740
Human ACE2-090H Recombinant Human ACE2 Protein, Fc-tagged Human cells Fc
Human ACE2-04H Recombinant Human ACE2 Protein, Human IgG1 Fc-tagged(C-ter) CHO Human IgG1 Fc(C-ter)
Human ACE2-026H Active Recombinant Human ACE2 Protein, hIgG/His-tagged HEK293 hIgG/His
Human ACE2-36H Recombinant Human ACE2 Protein, His-tagged HEK293F N-His Gln18-Ser740
Human ACE2-089H Recombinant Human ACE2 Protein, DYKDDDDK-tagged Human cells DYKDDDDK
Human ACE2-208H Active Recombinant Human ACE2 Protein, His\Avi-tagged Human Cell His\Avi
Human ACE2-26H Recombinant Human ACE2 Protein (ECD, processed, AA 20-708), Tag-free HEK293 Tag-free AA 20-708
Human ACE2-10H Active Recombinant Human ACE2 Protein, FLAG-tagged, Biotinylated HEK293 FLAG 18-740
Human ACE2-13H Recombinant Human ACE2 Protein, His-tagged Nicotiana Benthamiana His 19-615
Human ACE2-034H Recombinant Human ACE2 Protein, Fc-tagged CHO Fc 19-740
Human ACE2-0048H Recombinant Human ACE2 Protein HEK293 cells
Human ACE2-38H Recombinant Human ACE2 Protein, hFc-tagged HEK293 hFc
Human ACE2-32H Recombinant Human ACE2 Protein, His-tagged E.coli N-His Leu392-Ser740
Human ACE2-601H Active Recombinant Human ACE2 Protein, Fc-tagged CHO Fc 18-615
Human ACE2-2413H-B Recombinant Human ACE2 Protein Pre-coupled Magnetic Beads HEK293
Human ACE2-369H Recombinant Human ACE2 Protein (Gln18-Ser740), C-hFc-tagged HEK293 C-hFc Gln18-Ser740
Human ACE2-33H Recombinant Human ACE2 Protein, His-tagged HEK293F N-His Gln18-Ser740
Human ACE2-301568H Recombinant Human ACE2 protein, GST-tagged E.coli GST Asp30-Phe356
Human ACE2-39H Recombinant Human ACE2 Protein, His-tagged E.coli N-His Leu392-Ser740
Human ACE2-5060H Recombinant Human ACE2 Protein (Ser19-Ser740), C-His tagged Mammalian cells C-His Ser19-Ser740
Human ACE2-25H Recombinant Human ACE2 Protein (ECD, processed, AA 20-708), Tag-free HEK293 Tag-free AA 20-708
Human ACE2-2452H Recombinant Human ACE2 protein, His-tagged E.coli His 392-744 aa
Human ACE2-1071HFL Recombinant Human ACE2 protein, His&Flag-tagged HEK293 His&Flag 1-805 aa
Human ACE2-5062H Recombinant Human ACE2 Protein (Ser19-Ser740), HRP Labeled Mammalian cells Tag Free Ser19-Ser740
Human ACE2-23H Recombinant Human ACE2 Protein (ECD, AA 20-707), C-Avi/His-Tagged, Biotinylated HEK293 C-Avi/His AA 20-707
Human ACE2-40H Recombinant Human ACE2 Protein, His-tagged E.coli N-His Gln18-Ser740
Human ACE2-5059H Recombinant Human ACE2 Protein (Ser19-Asp615), C-Fc tagged Mammalian cells C-Fc Ser19-Asp615
Human ACE2-0464H Recombinant Human ACE2 Protein (M1-S740), Tag Free Insect Cell No tag M1-S740
Human ACE2-24H Recombinant Human ACE2 Protein (ECD, AA 20-707), C-Avi/His-Tagged, non-biotinylated HEK293 C-Avi/His AA 20-707
Human ACE2-0465H Recombinant Human ACE2 protein(Met1-Ser740), His-tagged Insect Cells C-His Met1-Ser740
Human ACE2-5061H Recombinant Human ACE2 Protein (Ser19-Ser740) Mammalian cells Tag Free Ser19-Ser740
Human ACE2-2186H Active Recombinant Human ACE2 protein, mFc-tagged HEK293 mFc Met1-Ser740
Human ACE2-2413H Recombinant Human ACE2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human ACE2-2165H Active Recombinant Human ACE2 protein, His-tagged HEK293 His Met1-Ser740
Human ACE2-2880H Active Recombinant Human ACE2 protein, His-Avi-tagged, Biotinylated HEK293 His-Avi Gln 18-Ser 611
Human ACE2-264H Recombinant Human ACE2 Protein (Gln18-Ser740), C-Fc tagged, Animal-free, Carrier-free HEK293 C-Fc Gln18-Ser740
Human ACE2-2881H Active Recombinant Human ACE2 protein, His-Avi-tagged, Biotinylated HEK293 His-Avi Gln 18 - Ser 740
Human ACE2-0077H Recombinant Human ACE2 Protein (Leu391-Ser740), N-His-tagged E.coli N-His Leu391-Ser740
Human ACE2-0076H Recombinant Human ACE2 Protein (Gln18-Ser740), C-His-tagged Mammalian cells C-His Gln18-Ser740
Human ACE2-0078H Recombinant Human ACE2 Protein (Leu392-Ser740), His-tagged E.coli His Leu392-Ser740
Human ACE2-370H Recombinant Human ACE2 Protein (Gln18-Ser740), C-mFc-tagged HEK293 C-mFc Gln18-Ser740
Human ACE2-5058H Recombinant Human ACE2 Protein (Ser19-Asp615), C-His tagged Mammalian cells C-His Ser19-Asp615
Human ACE2-2012M Active ACE2 protein-coupled magnetic Beads HEK293 Gln 18 - Ser 740
Human ACE2-1368H Recombinant Human ACE2 protein(Met1-Ser740), hFc-tagged, Biotinylated HEK293 C-hFc Met1-Ser740
Mouse ACE2-69M Active Recombinant Mouse ACE2, FLAG-tagged HEK293 Flag
Mouse Ace2-1183M Recombinant Mouse Ace2 protein, His&hFc-tagged HEK293 His&hFc Met1-Thr740
Mouse Ace2-1184M Recombinant Mouse ACE2 protein(Met1-Thr740), His-tagged HEK293 C-His Met1-Thr740
Mouse Ace2-761M Recombinant Mouse Ace2 protein, His-tagged HEK293 His Gln 18 - Thr 740
Mouse Ace2-1930M Recombinant Mouse Ace2 protein, His & T7-tagged E.coli His/T7 Ile93~Phe464 (Accession # Q8R0I0)
Mouse ACE2-2085MCL Recombinant Mouse ACE2 cell lysate Human Cell N/A
Mouse Ace2-34M Recombinant Mouse Ace2 Protein, His-tagged E.coli N-His Ile93-Phe464
Mouse ACE2-35M Recombinant Mouse ACE2 Protein, His-tagged Human Cell His
Mouse Ace2-37M Recombinant Mouse Ace2 Protein, His-tagged HEK293F N-His Gln18-Thr740
Rat Ace2-639R Active Recombinant Rat Ace2, His-tagged Mammalian cells His
Rat Ace2-603R Active Recombinant Rat ACE2 Protein, Fc-tagged CHO Fc 18-740
Rat Ace2-1931R Recombinant Rat Ace2 protein, His & T7-tagged E.coli His/T7 Leu392~Val739 (Accession # Q5EGZ1)
Rat Ace2-1194R Active Recombinant Rat Ace2 protein(Met1-Thr740), His-tagged HEK293 C-His Met1-Thr740
Rat ACE2-1851RCL Recombinant Rat ACE2 cell lysate Human Cell N/A
Rat Ace2-35R Recombinant Rat Ace2 Protein, His-tagged E.coli N-His Leu392-Val739
Rat Ace2-38R Recombinant Rat Ace2 Protein, His-tagged HEK293F N-His Met1-Thr740
Rat Ace2-09R Active Recombinant Rat Ace2 Protein, His-tagged Insect Cell His
Rat Ace2-033R Recombinant Rat ACE2 Protein, Fc-tagged CHO Fc 18-740
Rat Ace2-105R Recombinant Rat Ace2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Ace2-105R-B Recombinant Rat Ace2 Protein Pre-coupled Magnetic Beads HEK293
Rhesus monkey ACE2-206R Active Recombinant Rhesus monkey ACE2 protein, His-tagged HEK293 His Met1-Val739
Dog ACE2-602D Active Recombinant Dog ACE2 Protein, Fc-tagged CHO Fc 18-739
Dog ACE2-032D Recombinant Dog ACE2 Protein, Fc-tagged CHO Fc 18-739
Cynomolgus ACE2-108C Recombinant Cynomolgus ACE2 protein, His-tagged HEK293 His Gln18-Thr741
Cynomolgus ACE2-109CB Recombinant Cynomolgus ACE2 protein, His-Avi-tagged, Biotinylated HEK293 His-Avi Gln18-Val739
Cynomolgus ACE2-109C Recombinant Cynomolgus ACE2 protein, His-Avi-tagged HEK293 His-Avi Gln18-Val739
Cynomolgus monkey ACE2-018C Active Recombinant Cynomolgus monkey ACE2 protein, hFc-tagged Mammalian cell hFc 18-741aa
Cynomolgus Monkey ACE2-107C Recombinant Cynomolgus ACE2, Fc tagged Human Cell Fc
Cynomolgus Monkey ACE2-887CCL Recombinant Cynomolgus ACE2 cell lysate Human Cell N/A
Mink ACE2-2879M Active Recombinant Mink ACE2 protein, His-tagged HEK293 His Gln 18-Thr 740
Paguma larvata ACE2-019P Active Recombinant Paguma larvata ACE2 protein, hFc-tagged Mammalian cell hFc 18-740aa
Paguma larvata ACE2-2882P Active Recombinant Paguma larvata ACE2 protein, His-tagged HEK293 His Gln 18-Thr 740
Rhesus ACE2-207R Active Recombinant Rhesus ACE2 protein, hFc-tagged HEK293 hFc Met1-Val739
Rhesus Macaque ACE2-37R Recombinant Rhesus Macaque ACE2 Protein, Fc-tagged Human Cell Fc
Rhesus Macaque ACE2-36R Recombinant Rhesus Macaque ACE2 Protein, His-tagged Human Cell His
SARS-CoV-2 ACE2-007M Human ACE2-coupled magnetic beads
Zebrafish ACE2-1691Z Recombinant Zebrafish ACE2 Mammalian Cell His
Kit-2101 Angiotensin II Converting Enzyme Inhibitor Screening Kit N/A
Kit-2210 Angiotensin II Converting Enzyme (ACE2) Activity Assay Kit (Fluorometric) N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

ACE2 involved in several pathways and played different roles in them. We selected most pathways ACE2 participated on our site, such as Renin-angiotensin system, Protein digestion and absorption, which may be useful for your reference. Also, other proteins which involved in the same pathway with ACE2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Renin-angiotensin systemCTSA;NLN;KLK1B1;PRCP;KLK1B9;KLK1B11;LNPEP;ATP6AP2;REN2
Protein digestion and absorptionSLC9A3;PRCP;CELA3A;XPNPEP2;COL27A1;COL13A1;CPA2;SLC16A10;ATP1A1

ACE2 has several biochemical functions, for example, carboxypeptidase activity, endopeptidase activity, glycoprotein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ACE2 itself. We selected most functions ACE2 had, and list some proteins which have the same functions with ACE2. You can find most of the proteins on our site.

Function Related Protein
carboxypeptidase activityNAALAD2;ACE;CPB1;CNDP2;PGCP;AGBL4;CPE;CPM;NAALADL1
endopeptidase activityPSMB5;NCSTN;APH1B;KLK1B26;PSMB8F;CPS1;RHBDD1;TRAPPC12;PSEN2
glycoprotein bindingLGALS1;EDEM1;LRRK2;Serpina1c;IGF2R;CSNK1D;HFE2;SERPINA1A;Serpina1b
NOT metallopeptidase activity
NOT peptidyl-dipeptidase activity
protein bindingZNF576;PPIE;C10orf81;SPATA22;SFTPD;GOLM1;BAZ1A;STX6;PDIA3
virus receptor activityCLEC4M;HTR2A;PVRL2;PVRL4;SCARB1;TFRC;CD4;TNFRSF4;ACE2
zinc ion bindingZC3HC1;ZDHHC5A;NR1D2A;ADAMTS4;RNF31;NPSN;SIAH2;PHF20B;PML

ACE2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACE2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ACE2.

CALM1

Research Area

Related articles

Sui, JH; Deming, M; et al. Effects of Human Anti-Spike Protein Receptor Binding Domain Antibodies on Severe Acute Respiratory Syndrome Coronavirus Neutralization Escape and Fitness. JOURNAL OF VIROLOGY 88:13769-13780(2014).
Prasad, T; Verma, A; et al. Expression and cellular localization of the Mas receptor in the adult and developing mouse retina. MOLECULAR VISION 20:1443-1455(2014).
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