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Official Full Name angiotensin I converting enzyme 2
Background The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. The organ- and cell-specific expression of this gene suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. In addition, the encoded protein is a functional receptor for the spike glycoprotein of the human coronaviruses SARS and HCoV-NL63. [provided by RefSeq, Jul 2008]
Synonyms ACE2; angiotensin I converting enzyme 2; ACEH; angiotensin-converting enzyme 2; peptidyl-dipeptidase A; metalloprotease MPROT15; ACE-related carboxypeptidase; angiotensin-converting enzyme homolog; angiotensin I converting enzyme (peptidyl-dipeptidase A) 2;
    • Species :
    • Cynomolgus
    • Cynomolgus Monkey
    • Human
    • Mouse
    • Rat
    • Rhesus monkey
    • SARS-CoV-2
    • Zebrafish
    • Source :
    • CHO
    • E.coli
    • HEK293
    • HEK293T
    • Human Cell
    • Mammalian Cell
    • Mammalian cells
    • NS0
    • Tag :
    • Fc
    • His
    • Fc-Avi
    • Flag
    • hIgG/His
    • His/Avi
    • T7
    • His-Avi
    • human IgG1 Fc
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Cynomolgus ACE2-108C Recombinant Cynomolgus ACE2 protein, His-tagged HEK293 His
    Rhesus monkey ACE2-206R Recombinant Rhesus monkey ACE2 protein, His-tagged HEK293 His
    Rhesus monkey ACE2-207R Recombinant Rhesus monkey ACE2 protein, Fc-tagged HEK293 human IgG1 Fc
    Human ACE2-229H Recombinant Human ACE2 protein, His/Avi-tagged Mammalian cells His/Avi
    Human ACE2-230H Recombinant Human ACE2 Protein, His-Avi-Tagged, Biotinylated HEK293 His-Avi
    Human ACE2-231H Recombinant Human ACE2 Protein, Fc-Avi-Tagged, Biotinylated HEK293 Fc-Avi
    SARS-CoV-2 ACE2-007M Human ACE2-coupled magnetic beads
    Human ACE2-009H Recombinant Human ACE2 protein, Fc-tagged Human Cell Fc
    Human ACE2-026H Recombinant Human ACE2 Protein, hIgG/His-tagged HEK293 hIgG/His
    Human ACE2-02H Recombinant Human ACE2 Protein, Fc-tagged CHO Fc
    Human ACE2-091H Recombinant Human ACE2 Protein, Fc-Avi-tagged HEK293 Fc-Avi
    Cynomolgus ACE2-109C Recombinant Cynomolgus ACE2 protein, His-Avi-tagged HEK293 His-Avi
    Cynomolgus ACE2-109CB Recombinant Cynomolgus ACE2 protein, His-Avi-tagged, Biotinylated HEK293 His-Avi
    Human ACE2-185H Recombinant Human ACE2 Protein, Fc-tagged HEK293 Fc
    Human ACE2-3100HCL Recombinant Human ACE2 cell lysate Human Cell N/A
    Human ACE2-67H Recombinant Human ACE2, FLAG-tagged HEK293 Flag
    Human ACE2-68H Recombinant Human ACE2, Fc-tagged HEK293 Fc
    Human ACE2-735H Recombinant Human ACE2 Protein, His-tagged HEK293T His
    Human ACE2-736H Recombinant Human ACE2, His-tagged HEK293 His
    Human ACE2-745H Recombinant Human ACE2, His-tagged NS0 His
    Mouse Ace2-1183M Recombinant Mouse Ace2, Fc-His tagged Human Cell Fc/His
    Mouse Ace2-1184M Recombinant Mouse Ace2, His tagged Human Cell His
    Mouse Ace2-1930M Recombinant Mouse Ace2 protein, His & T7-tagged E.coli His/T7
    Mouse ACE2-2085MCL Recombinant Mouse ACE2 cell lysate Human Cell N/A
    Mouse ACE2-69M Recombinant Mouse ACE2, FLAG-tagged HEK293 Flag
    Mouse Ace2-761M Recombinant Mouse Ace2 Protein, His-tagged CHO His
    Rat Ace2-1194R Recombinant Rat Ace2, His tagged Human Cell His
    Rat ACE2-1851RCL Recombinant Rat ACE2 cell lysate Human Cell N/A
    Rat Ace2-1931R Recombinant Rat Ace2 protein, His & T7-tagged E.coli His/T7
    Rat Ace2-639R Recombinant Rat Ace2, His-tagged NS0 His
    Cynomolgus Monkey ACE2-107C Recombinant Cynomolgus ACE2, Fc tagged Human Cell Fc
    Cynomolgus Monkey ACE2-887CCL Recombinant Cynomolgus ACE2 cell lysate Human Cell N/A
    Zebrafish ACE2-1691Z Recombinant Zebrafish ACE2 Mammalian Cell His
    Kit-2101 Angiotensin II Converting Enzyme Inhibitor Screening Kit N/A
    Kit-2210 Angiotensin II Converting Enzyme (ACE2) Activity Assay Kit (Fluorometric) N/A

    ace2 involved in several pathways and played different roles in them. We selected most pathways ace2 participated on our site, such as Renin-angiotensin system, Protein digestion and absorption, which may be useful for your reference. Also, other proteins which involved in the same pathway with ace2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Renin-angiotensin system REN; AGTR1B; KLK1B26; KLK1; KLK1B8; CMA1; CPA3; ATP6AP2; THOP1; KLK1B5
    Protein digestion and absorption SLC8A1; COL24A1; ATP1B1; MEP1B; COL15A1; ATP1B2; ACE2; PGA4; ELN; CELA3B

    ace2 has several biochemical functions, for example, carboxypeptidase activity, endopeptidase activity, glycoprotein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ace2 itself. We selected most functions ace2 had, and list some proteins which have the same functions with ace2. You can find most of the proteins on our site.

    Function Related Protein
    carboxypeptidase activity PGCP; AEBP1; CPE; CPD; CPM; CPA2; AGBL4; CPB1; AGBL1; NAALAD2
    endopeptidase activity PARL; PSMA4; AP1S2; KLK1B22; KLK1B5; P4HB; ACE; HTRA4; ELANE; CD46
    NOT metallopeptidase activity ACE2
    NOT peptidyl-dipeptidase activity ACE2
    protein binding OCLN; STAM; KRTAP10-8; SRI; MLF2; CYP4F2; RAF1; SCFD1; EXOSC4; RAB32
    virus receptor activity SLC20A2; PVR; NCAM1; SLC52A2; ITGB7; CD209; EFNB3; IDE; SCARB1; AXL
    zinc ion binding TRIM67; MORC3A; ZDHHC8B; RLIM; TAF15; LONRF2; PDLIM4; RNF32; ABLIM3; SP110

    ace2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ace2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ace2.


    Sui, JH; Deming, M; et al. Effects of Human Anti-Spike Protein Receptor Binding Domain Antibodies on Severe Acute Respiratory Syndrome Coronavirus Neutralization Escape and Fitness. JOURNAL OF VIROLOGY 88:13769-13780(2014).
    Prasad, T; Verma, A; et al. Expression and cellular localization of the Mas receptor in the adult and developing mouse retina. MOLECULAR VISION 20:1443-1455(2014).

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