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ACE2

Official Full Name

angiotensin I converting enzyme 2
Overview

The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. The organ- and cell-specific expression of this gene suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. In addition, the encoded protein is a functional receptor for the spike glycoprotein of the human coronaviruses SARS and HCoV-NL63. [provided by RefSeq, Jul 2008]
Synonyms

ACE2; angiotensin I converting enzyme 2; ACEH; angiotensin-converting enzyme 2; peptidyl-dipeptidase A; metalloprotease MPROT15; ACE-related carboxypeptidase; angiotensin-converting enzyme homolog; angiotensin I converting enzyme (peptidyl-dipeptidase A) 2;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads
Chromatography Reagents
Others
Assay Kits

Species

Cynomolgus
Cynomolgus monkey
Cynomolgus Monkey
Dog
Golden hamster
Human
Mink
Mouse
Paguma larvata
Rat
Rhesus
Rhesus Macaque
Rhesus monkey
SARS-CoV-2
Zebrafish

Source

CHO
CHO cells
E.coli
HEK293
HEK293 cells
HEK293F
HEK293T
Human Cell
Human cells
Insect Cell
Insect Cells
Mammalian cell
Mammalian Cell
Mammalian cells
Nicotiana Benthamiana

Tag

C
His
Avi
CHO
Fc
Flag
FLAG
GST
HEK293
T7
mFc
N
Strep II
Non

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	ACE2-736H	Active Recombinant Human ACE2 protein, His-tagged	HEK293	His	Gln18-Ser740	$298 / 10μg $529 / 50μg $698 / 100μg
Human	ACE2-68H	Active Recombinant Human ACE2, Fc-tagged	HEK293	Fc	Met 1-Ser 740	$198 / 10μg $298 / 25μg $698 / 50μg
Human	ACE2-051H	Active Recombinant Human ACE2 protein, His/Avi-tagged, Biotinylated	CHO cells	His&Avi	Gln18 - Ser740	Inquiry
Human	ACE2-052H	Active Recombinant Human ACE2 protein, Fc/Avi-tagged, Biotinylated	CHO cells	Fc&Avi	Gln18-Ser740	Inquiry
Human	ACE2-736HA	Active Recombinant Human ACE2, His-tagged, APC labeled	HEK293	His		$298 / 5μg $498 / 10μg $1,298 / 50μg $1,898 / 100μg $8,998 / 1mg
Human	ACE2-817HB	Active Recombinant Human ACE2 protein, mFc-Avi-tagged	Mammalian cell	mFc&Avi	18-740aa	Inquiry
Human	ACE2-1082H	Recombinant Human ACE2 protein(Met1-Ser740), His-tagged, Biotinylated	HEK293	His	Met1-Ser740	Inquiry
Human	ACE2-3407H	Active Recombinant Human ACE2 protein(Met1-Ser740), His-Avi-tagged, Biotinylated	Insect Cells	His&Avi	Met1-Ser740	Inquiry
Human	ACE2-185H	Active Recombinant Human ACE2 protein, mFc-tagged	HEK293	mFc	Gln 18 - Ser 740	$198 / 10μg $298 / 25μg $698 / 500 μg
Human	ACE2-67H	Active Recombinant Human ACE2, FLAG-tagged	HEK293	Flag	1-740	Inquiry
Human	ACE2-239H	Recombinant Human ACE2, Fc tagged	Human Cell	Fc	Met1-Ser740	$786 / 20 µg
Human	ACE2-745H	Recombinant Human ACE2, His-tagged	Mammalian cells	His	1-740	Inquiry
Human	ACE2-735H	Recombinant Human ACE2 Protein, His-tagged	HEK293T	His		Inquiry
Human	ACE2-3100HCL	Recombinant Human ACE2 cell lysate	Human Cell	Non		Inquiry
Human	ACE2-091H	Recombinant Human ACE2 Protein, Fc-tagged	Human cells	Fc	Gln18-Arg708	Inquiry
Human	ACE2-009H	Active Recombinant Human ACE2 protein, Fc-tagged	Human Cell	Fc		Inquiry
Human	ACE2-031H	Recombinant Human ACE2 Protein, Fc-tagged	CHO	Fc	18-615	Inquiry
Human	ACE2-229H	Recombinant Human ACE2 protein, His/Avi-tagged	Mammalian cells	His&Avi	723	$3,298 / 500μg
Human	ACE2-01H	Recombinant Human ACE2 Protein (ECD), Avi-His-tagged(C-ter)	HEK293	His&Avi	Gln18-Ser740	Inquiry
Human	ACE2-230H	Recombinant Human ACE2 Protein, His-Avi-Tagged, Biotinylated	HEK293	His&Avi	Gln 18 - Ser 740	Inquiry
Human	ACE2-231H	Recombinant Human ACE2 Protein, Fc-Avi-Tagged, Biotinylated	HEK293	Fc&Avi	Gln 18 - Ser 740	Inquiry
Human	ACE2-092H	Recombinant Human ACE2 (Gln18-Ser740) Protein, Fc-tagged	Human cells	Fc	Gln18-Ser740	Inquiry
Human	ACE2-03H	Recombinant Human ACE2 Protein (ECD), His-tagged(N-ter)	HEK293	His	Gln18-Ser740	Inquiry
Human	ACE2-604H	Active Recombinant Human ACE2 Protein, Fc-tagged	CHO	Fc	18-615	Inquiry
Human	ACE2-02H	Recombinant Human ACE2 Protein (ECD), Fc-tagged(C-ter)	HEK293	Fc	Gln18-Ser740	Inquiry
Human	ACE2-090H	Recombinant Human ACE2 Protein, Fc-tagged	Human cells	Fc	Gln18-Asp615	Inquiry
Human	ACE2-04H	Recombinant Human ACE2 Protein, Human IgG1 Fc-tagged(C-ter)	CHO	Fc		Inquiry
Human	ACE2-026H	Active Recombinant Human ACE2 Protein, hIgG/His-tagged	HEK293	His&Fc		Inquiry
Human	ACE2-36H	Recombinant Human ACE2 Protein, His-tagged	HEK293F	His	Gln18-Ser740	Inquiry
Human	ACE2-089H	Recombinant Human ACE2 Protein, DYKDDDDK-tagged	Human cells	Flag		Inquiry
Human	ACE2-208H	Active Recombinant Human ACE2 Protein, His\Avi-tagged	Human Cell	His&Avi	Gln18-Ser740	Inquiry
Human	ACE2-26H	Recombinant Human ACE2 Protein (ECD, processed, AA 20-708), Tag-free	HEK293	Non	AA 20-708	Inquiry
Human	ACE2-10H	Active Recombinant Human ACE2 Protein, FLAG-tagged, Biotinylated	HEK293	FLAG	18-740	Inquiry
Human	ACE2-13H	Recombinant Human ACE2 Protein, His-tagged	Nicotiana Benthamiana	His	19-615	Inquiry
Human	ACE2-034H	Recombinant Human ACE2 Protein, Fc-tagged	CHO	Fc	19-740	Inquiry
Human	ACE2-0048H	Recombinant Human ACE2 Protein	HEK293 cells			Inquiry
Human	ACE2-38H	Recombinant Human ACE2 Protein, hFc-tagged	HEK293	Fc	18-740	Inquiry
Human	ACE2-32H	Recombinant Human ACE2 Protein, His-tagged	E.coli	His	Leu392-Ser740	Inquiry
Human	ACE2-601H	Active Recombinant Human ACE2 Protein, Fc-tagged	CHO	Fc	18-615	Inquiry
Human	ACE2-2413H-B	Recombinant Human ACE2 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Human	ACE2-369H	Recombinant Human ACE2 Protein (Gln18-Ser740), C-hFc-tagged	HEK293	Fc	Gln18-Ser740	Inquiry
Human	ACE2-33H	Recombinant Human ACE2 Protein, His-tagged	HEK293F	His	Gln18-Ser740	Inquiry
Human	ACE2-301568H	Recombinant Human ACE2 protein, GST-tagged	E.coli	GST	Asp30-Phe356	Inquiry
Human	ACE2-39H	Recombinant Human ACE2 Protein, His-tagged	E.coli	His	Leu392-Ser740	Inquiry
Human	ACE2-5060H	Recombinant Human ACE2 Protein (Ser19-Ser740), C-His tagged	Mammalian cells	His	Ser19-Ser740	Inquiry
Human	ACE2-25H	Recombinant Human ACE2 Protein (ECD, processed, AA 20-708), Tag-free	HEK293	Non	AA 20-708	Inquiry
Human	ACE2-2452H	Recombinant Human ACE2 protein, His-tagged	E.coli	His	392-744 aa	$319 / 25μg
Human	ACE2-1071HFL	Recombinant Human ACE2 protein, His&Flag-tagged	HEK293	His&Flag	1-805 aa	Inquiry
Human	ACE2-5062H	Recombinant Human ACE2 Protein (Ser19-Ser740), HRP Labeled	Mammalian cells	Non	Ser19-Ser740	Inquiry
Human	ACE2-23H	Recombinant Human ACE2 Protein (ECD, AA 20-707), C-Avi/His-Tagged, Biotinylated	HEK293	His&Avi	AA 20-707	Inquiry
Human	ACE2-40H	Recombinant Human ACE2 Protein, His-tagged	E.coli	His	Gln18-Ser740	Inquiry
Human	ACE2-5059H	Recombinant Human ACE2 Protein (Ser19-Asp615), C-Fc tagged	Mammalian cells	Fc	Ser19-Asp615	Inquiry
Human	ACE2-2186H	Active Recombinant Human ACE2 protein, mFc-tagged	HEK293	mFc	Met1-Ser740	Inquiry
Human	ACE2-24H	Recombinant Human ACE2 Protein (ECD, AA 20-707), C-Avi/His-Tagged, non-biotinylated	HEK293	His&Avi	AA 20-707	Inquiry
Human	ACE2-2165H	Active Recombinant Human ACE2 protein, His-tagged	HEK293	His	Met1-Ser740	Inquiry
Human	ACE2-5061H	Recombinant Human ACE2 Protein (Ser19-Ser740)	Mammalian cells	Non	Ser19-Ser740	Inquiry
Human	ACE2-264H	Recombinant Human ACE2 Protein (Gln18-Ser740), C-Fc tagged, Animal-free, Carrier-free	HEK293	Fc	Gln18-Ser740	Inquiry
Human	ACE2-2413H	Recombinant Human ACE2 Protein, His (Fc)-Avi-tagged	HEK293	His&Fc&Avi		Inquiry
Human	ACE2-0464H	Recombinant Human ACE2 Protein (M1-S740), Tag Free	Insect Cell	Non	M1-S740	Inquiry
Human	ACE2-2880H	Active Recombinant Human ACE2 protein, His-Avi-tagged, Biotinylated	HEK293	His&Avi	Gln 18-Ser 611	Inquiry
Human	ACE2-0465H	Recombinant Human ACE2 protein(Met1-Ser740), His-tagged	Insect Cells	His	Met1-Ser740	Inquiry
Human	ACE2-2881H	Recombinant Human ACE2 protein, His-Avi-tagged, Biotinylated	HEK293	C-His-Avi	Gln18-Ser740	Inquiry
Human	ACE2-0077H	Recombinant Human ACE2 Protein (Leu391-Ser740), N-His-tagged	E.coli	His	Leu391-Ser740	Inquiry
Human	ACE2-0076H	Recombinant Human ACE2 Protein (Gln18-Ser740), C-His-tagged	Mammalian cells	His	Gln18-Ser740	Inquiry
Human	ACE2-0078H	Recombinant Human ACE2 Protein (Leu392-Ser740), His-tagged	E.coli	His	Leu392-Ser740	Inquiry
Human	ACE2-370H	Recombinant Human ACE2 Protein (Gln18-Ser740), C-mFc-tagged	HEK293	mFc	Gln18-Ser740	Inquiry
Human	ACE2-5058H	Recombinant Human ACE2 Protein (Ser19-Asp615), C-His tagged	Mammalian cells	His	Ser19-Asp615	Inquiry
Human	ACE2-2012M	Active ACE2 protein-coupled magnetic Beads	HEK293		Gln 18 - Ser 740	Inquiry
Human	ACE2-1368H	Recombinant Human ACE2 protein(Met1-Ser740), hFc-tagged, Biotinylated	HEK293	Fc	Met1-Ser740	Inquiry
Mouse	ACE2-69M	Active Recombinant Mouse ACE2, FLAG-tagged	HEK293	Flag	1-740	Inquiry
Mouse	Ace2-1183M	Recombinant Mouse Ace2 protein, His&hFc-tagged	HEK293	His&Fc	Met1-Thr740	$786 / 5 µg
Mouse	Ace2-1184M	Recombinant Mouse ACE2 protein(Met1-Thr740), His-tagged	HEK293	His	Met1-Thr740	$786 / 10 µg
Mouse	Ace2-761M	Recombinant Mouse Ace2 protein, His-tagged	HEK293	His	Gln 18 - Thr 740	Inquiry
Mouse	Ace2-1930M	Recombinant Mouse Ace2 protein, His & T7-tagged	E.coli	His&T7	Ile93~Phe464	Inquiry
Mouse	ACE2-2085MCL	Recombinant Mouse ACE2 cell lysate	Human Cell	Non		Inquiry
Mouse	Ace2-34M	Recombinant Mouse Ace2 Protein, His-tagged	E.coli	His	Ile93-Phe464	Inquiry
Mouse	ACE2-35M	Recombinant Mouse ACE2 Protein, His-tagged	Human Cell	His	Gln18-Thr740	Inquiry
Mouse	Ace2-37M	Recombinant Mouse Ace2 Protein, His-tagged	HEK293F	His	Gln18-Thr740	Inquiry
Rat	Ace2-639R	Active Recombinant Rat Ace2, His-tagged	Mammalian cells	His	Met1-Thr740	Inquiry
Rat	Ace2-603R	Active Recombinant Rat ACE2 Protein, Fc-tagged	CHO	Fc	18-740	Inquiry
Rat	Ace2-1931R	Recombinant Rat Ace2 protein, His & T7-tagged	E.coli	His&T7	Leu392~Val739	Inquiry
Rat	Ace2-1194R	Active Recombinant Rat Ace2 protein(Met1-Thr740), His-tagged	HEK293	His	Met1-Thr740	$786 / 50 µg
Rat	ACE2-1851RCL	Recombinant Rat ACE2 cell lysate	Human Cell	Non		Inquiry
Rat	Ace2-35R	Recombinant Rat Ace2 Protein, His-tagged	E.coli	His	Leu392-Val739	Inquiry
Rat	Ace2-38R	Recombinant Rat Ace2 Protein, His-tagged	HEK293F	His	Met1-Thr740	Inquiry
Rat	Ace2-09R	Active Recombinant Rat Ace2 Protein, His-tagged	Insect Cell	His	18-740	Inquiry
Rat	Ace2-033R	Recombinant Rat ACE2 Protein, Fc-tagged	CHO	Fc	18-740	Inquiry
Rat	Ace2-105R	Recombinant Rat Ace2 Protein, His (Fc)-Avi-tagged	HEK293	His&Fc&Avi		Inquiry
Rat	Ace2-105R-B	Recombinant Rat Ace2 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rhesus monkey	ACE2-206R	Active Recombinant Rhesus monkey ACE2 protein, His-tagged	HEK293	His	Met1-Val739	Inquiry
Dog	ACE2-602D	Active Recombinant Dog ACE2 Protein, Fc-tagged	CHO	Fc	18-739	Inquiry
Dog	ACE2-032D	Recombinant Dog ACE2 Protein, Fc-tagged	CHO	Fc	18-739	Inquiry
Cynomolgus	ACE2-108C	Recombinant Cynomolgus ACE2 protein, His-tagged	HEK293	His	Gln18-Thr741	Inquiry
Cynomolgus	ACE2-109CB	Recombinant Cynomolgus ACE2 protein, His-Avi-tagged, Biotinylated	HEK293	His&Avi	Gln18-Val739	Inquiry
Cynomolgus	ACE2-109C	Recombinant Cynomolgus ACE2 protein, His-Avi-tagged	HEK293	His&Avi	Gln18-Val739	Inquiry
Cynomolgus monkey	ACE2-018C	Active Recombinant Cynomolgus monkey ACE2 protein, hFc-tagged	Mammalian cell	Fc	18-741aa	Inquiry
Cynomolgus Monkey	ACE2-107C	Recombinant Cynomolgus ACE2, Fc tagged	Human Cell	Fc	Met1-Val739	Inquiry
Cynomolgus Monkey	ACE2-887CCL	Recombinant Cynomolgus ACE2 cell lysate	Human Cell	Non		Inquiry
Golden hamster	Ace2-6325G	Recombinant Golden hamster Ace2 protein, His&Strep II-tagged	E.coli	N-His&C-Strep II	20-604aa	Inquiry
Mink	ACE2-2879M	Active Recombinant Mink ACE2 protein, His-tagged	HEK293	His	Gln 18-Thr 740	Inquiry
Paguma larvata	ACE2-019P	Active Recombinant Paguma larvata ACE2 protein, hFc-tagged	Mammalian cell	Fc	18-740aa	Inquiry
Paguma larvata	ACE2-2882P	Active Recombinant Paguma larvata ACE2 protein, His-tagged	HEK293	His	Gln 18-Thr 740	Inquiry
Rhesus	ACE2-207R	Active Recombinant Rhesus ACE2 protein, hFc-tagged	HEK293	Fc	Met1-Val739	Inquiry
Rhesus Macaque	ACE2-37R	Recombinant Rhesus Macaque ACE2 Protein, Fc-tagged	Human Cell	Fc	Gln18-Val739	Inquiry
Rhesus Macaque	ACE2-36R	Recombinant Rhesus Macaque ACE2 Protein, His-tagged	Human Cell	His	Gln18-Val739	Inquiry
SARS-CoV-2	ACE2-007M	Human ACE2-coupled magnetic beads				Inquiry
Zebrafish	ACE2-1691Z	Recombinant Zebrafish ACE2	Mammalian Cell	His		Inquiry
	ANG-013	Recombinant ACE2 Protein, His-tagged				Inquiry
	Kit-2210	Angiotensin II Converting Enzyme (ACE2) Activity Assay Kit (Fluorometric)		Non		Inquiry
	Kit-2101	Angiotensin II Converting Enzyme Inhibitor Screening Kit		Non		Inquiry
	HUM-291	Recombinant Human ACE2 Protein, sFc-tagged		HEK293		Inquiry
	ANG-014	Recombinant ACE2 Protein, hFc-tagged				Inquiry
	HUM-292	Recombinant Human ACE2 Protein, Fc-tagged		CHO		Inquiry
	HUM-290	Recombinant Human ACE2 Protein, Fc-tagged		CHO		Inquiry

Involved Pathway
Protein Function
Interacting Protein
Other Resource

ACE2 involved in several pathways and played different roles in them. We selected most pathways ACE2 participated on our site, such as Renin-angiotensin system, Protein digestion and absorption, which may be useful for your reference. Also, other proteins which involved in the same pathway with ACE2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Renin-angiotensin system	ANPEP;REN;KLK1B11;ATP6AP2;MAS1;KLK1;Ren1;REN2;KLK1B8
Protein digestion and absorption	SLC8A2;ATP1A1;CPA2;ATP1A2;ATP1B2;CELA2A;CELA3B;COL6A5;COL10A1

ACE2 has several biochemical functions, for example, carboxypeptidase activity, endopeptidase activity, glycoprotein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ACE2 itself. We selected most functions ACE2 had, and list some proteins which have the same functions with ACE2. You can find most of the proteins on our site.

Function	Related Protein
carboxypeptidase activity	AEBP1;AGBL4;CPM;AGBL1;ACE2;CNDP1;CPA2;CPB1;CPE
endopeptidase activity	KLK1B11;SENP3B;PSMB10;PSMB4;RHBDD1;ADAM10;ATG4B;PSMA8;REN2
glycoprotein binding	HSPA5;Serpina1b;VWF;SELP;IDE;CDH1;LDLR;ACE2;LMAN2
NOT metallopeptidase activity
NOT peptidyl-dipeptidase activity
protein binding	ZNF559;SKA1;ARHGEF4;TTC30B;NR2F2;DHH;CREM;RAD1;CLOCKB
virus receptor activity	GPR172B;CXCR4;HSPA1B;F11R;TNFRSF14;HYAL2;CR2;SLC52A2;CLDN1
zinc ion binding	APOBEC2;ZMYM2;MT1M;USP51;BRF1;BMP1B;MAP3K1;PHC3;CRIP2

ACE2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACE2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ACE2.

CALM1

Research Area

Renal Markers

Metalloproteases and Regulators

Sui, JH; Deming, M; et al. Effects of Human Anti-Spike Protein Receptor Binding Domain Antibodies on Severe Acute Respiratory Syndrome Coronavirus Neutralization Escape and Fitness. JOURNAL OF VIROLOGY 88:13769-13780(2014).

Prasad, T; Verma, A; et al. Expression and cellular localization of the Mas receptor in the adult and developing mouse retina. MOLECULAR VISION 20:1443-1455(2014).