| Description : |
Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors. Mutations in this gene are associated with fibrodysplasia ossificans progressive. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
57.15 kDa |
| AA Sequence : |
MVDGVMILPVLIMIALPSPSMEDEK PKVNPKLYMCVCEGLSCGNEDHCEG QQCFSSLSINDGFHVYQKGCFQVYE QGKMTCKTPPSPGQAVECCQGDWCN RNITAQLPTKGKSFPGTQNFHLEVG LIILSVVFAVCLLACLLGVALRKFK RRNQERLNPRDVEYGTIEGLITTNV GDSTLADLLDHSCTSGSGSGLPFLV QRTVARQITLLECVGKGRYGEVWRG SWQGENVAVKIFSSRDEKSWFRETE LYNTVMLRHENILGFIASDMTSRHS STQLWLITHYHEMGSLYDYLQLTTL DTVSCLRIVLSIASGLAHLHIEIFG TQGKPAIAHRDLKSKNILVKKNGQC CIADLGLAVMHSQSTNQLDVGNNPR VGTKRYMAPEVLDETIQVDCFDSYK RVDIWAFGLVLWEVARRMVSNGIVE DYKPPFYDVVPNDPSFEDMRKVVCV DQQRPNIPNRWFSDPTLTSLAKLMK ECWYQNPSARLTALRIKKTLTKIDN SLDKLKTDCTRTRPLEQKLISEEDL AANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
