Recombinant Human APPBP1 protein, GST-tagged

• Cat.No.: APPBP1-722H
• Product Overview: Human APPBP1 full-length ORF ( AAH00480, 1 a.a. - 534 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: The protein encoded by this gene binds to the beta-amyloid precursor protein. Beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimer's disease. In addition, the encoded protein can form a heterodimer with UBE1C and bind and activate NEDD8, a ubiquitin-like protein. This protein is required for cell cycle progression through the S/M checkpoint. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 84.48 kDa
• AA Sequence: MAQLGKLLKEQKYDRQLRLWGDHGQ EALESAHVCLINATATGTEILKNLV LPGIGSFTIIDGNQVSGEDAGNNFF LQRSSIGKNRAEAAMEFLQELNSDV SGSFVEESPENLLDNDPSFFCRFTV VVATQLPESTSLRLADVLWNSQIPL LICRTYGLVGYMRIIIKEHPVIESH PDNALEDLRLDKPFPELREHFQSYD LDHMEKKDHSHTPWIVIIAKYLAQW YSETNGRIPKTYKEKEDFRDLIRQG ILKNENGAPEDEENFEEAIKNVNTA LNTTQIPSSIEDIFNDDRCINITKQ TPSFWILARALKEFVAKEGQGNLPV RGTIPDMIADSGKYIKLQNVYREKA KKDAAAVGNHVAKLLQSIGQAPESI SEKELKLLCSNSAFLRVVRCRSLAE EYGLDTINKDEIISSMDNPDNEIVL YLMLRAVDRFHKQQGRYPGVSNYQV EEDIGKLKSCLTGFLQEYGLSVMVK DDYVHEFCRYGAAEPHTIAAFLGGA AAQEVIKIITKQFVIFNNTYIYSGM SQTSATFQL
• Applications: Enzyme-linked Immunoabsorbent Assay; Western Blot (Recombinant protein); Antibody Production; Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: NAE1 NEDD8 activating enzyme E1 subunit 1 [ Homo sapiens ]
• Official Symbol: NAE1
• Synonyms: NAE1; NEDD8 activating enzyme E1 subunit 1; amyloid beta precursor protein binding protein 1 , amyloid beta precursor protein binding protein 1, 59kDa , amyloid beta precursor protein binding protein 1, 59kD , APPBP1; NEDD8-activating enzyme E1 regulatory subunit; NEDD8 activating enzyme E1 subunit; ula 1; APP-BP1; protooncogene protein 1; proto-oncogene protein 1; amyloid protein-binding protein 1; NEDD8-activating enzyme E1 subunit; amyloid beta precursor protein-binding protein 1, 59kD; amyloid beta precursor protein binding protein 1, 59kDa; amyloid beta precursor protein-binding protein 1, 59 kDa; HPP1; ula-1; APPBP1; A-116A10.1
• Gene ID: 8883
• mRNA Refseq: NM_001018159
• Protein Refseq: NP_001018169
• MIM: 603385
• UniProt ID: Q13564