Recombinant Human BABAM1 Protein, Myc/DDK-tagged, C13 and N15-labeled

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Recombinant Human BABAM1 Protein, Myc/DDK-tagged, C13 and N15-labeled

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Cat.No. : BABAM1-2255H
Product Overview : C19orf62 MS Standard C13 and N15-labeled recombinant protein (NP_054892) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.
Description : Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates. In these 2 complexes, it is probably required to maintain the stability of BABAM2 and help the 'Lys-63'-linked deubiquitinase activity mediated by BRCC3/BRCC36 component. The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1. Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activity by enhancing its stability and cell surface expression. Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination.
Source : HEK293
Species : Human
Tag : Myc/DDK
Molecular Mass : 36.6 kDa
AA Sequence : MEVAEPSSPT EEEEEEEEHS AEPRPRTRSN PEGAEDRAVG AQASVGSRSE GEGEAASADD GSLNTSGAGP KSWQVPPPAP EVQIRTPRVN CPEKVIICLD LSEEMSLPKL ESFNGSKTNA LNVSQKMIEM FVRTKHKIDK SHEFALVVVN DDTAWLSGLT SDPRELCSCL YDLETASCST FNLEGLFSLI QQKTELPVTE NVQTIPPPYV VRTILVYSRP PCQPQFSLTE PMKKMFQCPY FFFDVVYIHN GTEEKEEEMS WKDMFAFMGS LDTKGTSYKY EVALAGPALE LHNCMAKLLA HPLQRPCQSH ASYSLLEEED EAIEVEATVT RTRPLEQKLI SEEDLAANDI LDYKDDDDKV
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 3 months from receipt of products under proper storage and handling conditions.
Storage : Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
Concentration : 50 μg/mL as determined by BCA
Storage Buffer : 100 mM glycine, 25 mM Tris-HCl, pH 7.3.
SDS-PAGE :

Gene Name : BABAM1 BRISC and BRCA1 A complex member 1 [ Homo sapiens (human) ]
Official Symbol : BABAM1
Synonyms : BABAM1; BRISC and BRCA1 A complex member 1; C19orf62, chromosome 19 open reading frame 62; BRISC and BRCA1-A complex member 1; FLJ20571; HSPC142; Mediator of Rap80 Interactions and Targeting 40 kD; MERIT40; NBA1; new component of the BRCA1 A complex; BRCA1-A complex subunit MERIT40; new component of the BRCA1-A complex; new component of the BRCAA1 A complex; mediator of Rap80 interactions and targeting 40 kDa; mediator of RAP80 interactions and targeting subunit of 40 kDa; C19orf62;
Gene ID : 29086
mRNA Refseq : NM_014173
Protein Refseq : NP_054892
MIM : 612766
UniProt ID : Q9NWV8

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