Recombinant Human CCL11, StrepII-tagged
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Cat.No. : | CCL11-289H Optional Service: Optional requirements on this protein |
Product Overview : | Purified, full-length human recombinant CCL11 protein (amino acids 24-97, 74 a.a.) with StrepII tag, produced in human cells. Predicted molecular weight: 8.4 kDa. (Accession NP_002977; UniProt P51671) |
Description : | CCL11, a member of the CC subfamily, displays chemotactic activity for eosinophils, but not mononuclear cells or neutrophils. This eosinophil-specific chemokine is thought to be involved in eosinophilic inflammatory diseases such as atopic dermatitis, allergic rhinitis, asthma and parasitic infections. |
Source : | Human Cells |
Species : | Human |
Tag : | StrepII |
Form : | Lyophilized from sterile 0.2μm filtered solution in 0.3X PBS with 10% Trehalose (carrier-free) |
Protein length : | 24-97, 74 a.a. |
AA Sequence : | GPASVPTTCC FNLANRKIPL QRLESYRRIT SGKCPQKAVI FKTKLAKDIC ADPKKKWVQD SMKYLDQKSP TPKP |
Endotoxin : | <0.1 eu per μg protein by lal |
Purity : | ~80% by SDS-PAGE |
Storage : | 12 months at -20°C as supplied; 1 month at 4°C after reconstitution. Avoid freeze/thaw cycles. |
Reconstitution : | Centrifuge the vial prior to opening. Reconstitute in PBS to a concentration of 0.1 mg/ml |
Gene Name : | CCL11 chemokine (C-C motif) ligand 11 [ Homo sapiens ] |
Official Symbol : | CCL11 |
Synonyms : | CCL11; chemokine (C-C motif) ligand 11; SCYA11, small inducible cytokine subfamily A (Cys Cys), member 11 (eotaxin); eotaxin; eotaxin 1; MGC22554; eotaxin-1; C-C motif chemokine 11; small-inducible cytokine A11; eosinophil chemotactic protein; small inducible cytokine subfamily A (Cys-Cys), member 11 (eotaxin); SCYA11; |
Gene ID : | 6356 |
mRNA Refseq : | NM_002986 |
Protein Refseq : | NP_002977 |
MIM : | 601156 |
UniProt ID : | P51671 |
Chromosome Location : | 17q21.1-q21.2 |
Pathway : | Asthma, organism-specific biosystem; Asthma, conserved biosystem; CXCR3-mediated signaling events, organism-specific biosystem; Chemokine receptors bind chemokines, organism-specific biosystem; Chemokine signaling pathway, organism-specific biosystem; Chemokine signaling pathway, conserved biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; |
Function : | chemokine activity; |
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◆ Lysates
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CCL1CCL11Ccl12CCL13CCL14CCL15CCL16CCL17CCL18CCL19CCL2CCL20CCL21Ccl21cCCL22CCL23CCL24CCL25CCL26CCL27Ccl27aCCL28CCL3CCL3L1Ccl4CCL5Ccl6CCL7CCL8Ccl9CCL4L2Ccl21aCCL4L1CCL3L3Ccl21bCcl27b
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