Recombinant Human CDK8/CCNC protein, GST-tagged
Cat.No. : | CDK8-CCNC-314H |
Product Overview : | Recombinant full-length human CDK8/CCNC was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. |
- Specification
- Gene Information
- Related Products
Description : | CDK8 is a member of the CDK family which are important regulators of cell cycle progression. CDK8 associates with Cyclin C and is a component of the RNA polymerase II holoenzyme complex that phosphorylates the carboxy-terminal domain (CTD) of the largest subunit of RNA polymerase II. CDK8 regulate transcription by targeting the CDK7/cyclin H subunits of the general transcription initiation factor IIH (TFIIH). Inhibition of CDK8 expression inhibits proliferation in colon cancer cells characterized by high levels of CDK8 and beta-catenin hyperactivity. CDK8 kinase activity is necessary for β-catenin-driven transformation and for expression of several β-catenin transcriptional targets. |
Source : | Insect cell |
Species : | Human |
Tag : | GST |
Form : | 50mM Tris-HCl, pH 7.5, 50mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol |
Molecular Mass : | CDK8 ~84kDa and CCNC ~55 kDa |
Purity : | The purity of CDK8/CCNC was determined to be >70% by densitometry. |
Applications : | WB |
Stability : | 1 year at -70 centigrade |
Storage : | Store product at -70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
Concentration : | 0.1 μg/μL |
Gene Name : | cyclin dependent kinase 8 [ Homo sapiens (human) ]; cyclin C [ Homo sapiens (human) ] |
Official Symbol : | CDK8; CCNC |
Synonyms : | CDK8: K35, MGC126074, MGC126075; CyclinC; CCNC; CycC |
Gene ID : | 1024; 892 |
mRNA Refseq : | NM_001260; NM_005190 |
Protein Refseq : | NP_001251; NP_005181.2 |
MIM : | 603184; 123838 |
UniProt ID : | P49336; P24863 |
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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