Recombinant Human CENPB Protein, MYC/DDK-tagged

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Recombinant Human CENPB Protein, MYC/DDK-tagged

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Cat.No. : CENPB-3184H
Product Overview : Recombinant Human CENPB protein, fused to MYC/DDK-tagged at C-terminus, was expressed in HEK293.
Description : This gene product is a highly conserved protein that facilitates centromere formation. It is a DNA-binding protein that is derived from transposases of the pogo DNA transposon family. It contains a helix-loop-helix DNA binding motif at the N-terminus, and a dimerization domain at the C-terminus. The DNA binding domain recognizes and binds a 17-bp sequence (CENP-B box) in the centromeric alpha satellite DNA. This protein is proposed to play an important role in the assembly of specific centromere structures in interphase nuclei and on mitotic chromosomes. It is also considered a major centromere autoantigen recognized by sera from patients with anti-centromere antibodies.
Source : HEK293
Species : Human
Tag : MYC/DDK
Form : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Mass : 65 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration : >50 ug/mL as determined by microplate BCA method
Gene Name : CENPB centromere protein B, 80kDa [ Homo sapiens ]
Official Symbol : CENPB
Synonyms : OTTHUMP00000030132; centromere autoantigen B; centromere protein B; centromere protein B (80kD); centromere protein B, 80kDa
Gene ID : 1059
mRNA Refseq : NM_001810
Protein Refseq : NP_001801
MIM : 117140
UniProt ID : P07199

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