Recombinant Human ENPP2 Protein (Ser637-Ile905), His tagged

• Cat.No.: ENPP2-2668H
• Product Overview: Recombinant human ENPP2 (Ser637-Ile905) protein fused with His tag was expressed in E. coli.

Specification

• Description: ENPP2 (Ectonucleotide pyrophosphatase/phosphodiesterase family member 2), also referred as Autotaxin, is a secreted enzyme encoded by the ENPP2 gene. This gene product stimulates the motility of tumor cells, has angiogenic properties, and its expression is upregulated in several kinds of carcinomas. The Autotaxin protein is important for generating the lipid signaling molecule lysophosphatidic acid (LPA), which is a potent mitogen, which facilitates cell proliferation and migration, neurite retraction, platelet aggregation, smooth muscle contraction, actin stress formation and cytokine and chemokine secretion. ATX has been found to catalyze the formation of cyclic phosphatidic acid (cPA), which have antitumor role by antimitogenic regulation of cell cycle, inhibition of cancer invasion and metastasis. LPA receptors and ATX are upregulated in numerous cancer cell types and show expression patterns that correlate with tumor cell invasiveness. Thus, Autotaxin has recently emerged as an attractive target for the development of anti-cancer chemotherapeutics. In addition, Serum ATX activity was found to be enhanced in relation to hepatic fibrosis in chronic liver disease due to hepatitis virus C infection.
• Source: E. coli
• Species: Human
• Tag: His
• Molecular Mass: 27.14 kDa
• Protein Length: Ser637-Ile905
• Purity: >90 % as determined by SDS-PAGE.
• Notes: For research use only.
• Storage: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 centigrade for one week. Store at -20 to -80 centigrade for twelve months from the date of receipt.
• Storage Buffer: Supplied as solution form in PBS pH 7.5 or lyophilized from PBS pH 7.5.
• Reconstitution: Reconstitute in sterile water for a stock solution.
• Shipping: In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.

Gene Information

• Gene Name: ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2 [ Homo sapiens (human) ]
• Official Symbol: ENPP2
• Synonyms: ENPP2; ectonucleotide pyrophosphatase/phosphodiesterase 2; PDNP2; ectonucleotide pyrophosphatase/phosphodiesterase family member 2; ATX; autotaxin; PD IALPHA; E-NPP 2; autotaxin-t; plasma lysophospholipase D; extracellular lysophospholipase D; phosphodiesterase I/nucleotide pyrophosphatase 2; NPP2; ATX-X; LysoPLD; AUTOTAXIN; PD-IALPHA; FLJ26803
• Gene ID: 5168
• mRNA Refseq: NM_001040092
• Protein Refseq: NP_001035181
• MIM: 601060
• UniProt ID: Q13822