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Recombinant Human F3 Protein, His-tagged

Cat.No.: F3-2046H
Product Overview: Recombinant Human Coagulation Factor III/Tissue Factor/CD142 Protein is produced by HEK293 expression system. The target protein is expressed with sequence (Gly34-Glu251) of human Coagulation Factor III/Tissue Factor/CD142 (Accession #NP_001984.1) fused with a 6×His tag at the C-terminus.
Description: This gene encodes coagulation factor III which is a cell surface glycoprotein. This factor enables cells to initiate the blood coagulation cascades, and it functions as the high-affinity receptor for the coagulation factor VII. The resulting complex provides a catalytic event that is responsible for initiation of the coagulation protease cascades by specific limited proteolysis. Unlike the other cofactors of these protease cascades, which circulate as nonfunctional precursors, this factor is a potent initiator that is fully functional when expressed on cell surfaces. There are 3 distinct domains of this factor: extracellular, transmembrane, and cytoplasmic. This protein is the only one in the coagulation pathway for which a congenital deficiency has not been described. Alternate splicing results in multiple transcript variants.
Source: HEK293
Species: Human
Tag : His
Form: Lyophilized from sterile PBS, pH 7.4, 5 % trehalose, 5 % mannitol.
Protein length: Gly34-Glu251
Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.
Purity: > 90% as determined by SDS-PAGE
Stability: Samples are stable for up to twelve months from date of receipt at -70ºC.
Storage: Store it under sterile conditions at -20ºC~-70ºC. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4ºC before opening to recover the entire contents.
Gene Name: F3 coagulation factor III (thromboplastin, tissue factor) [ Homo sapiens ]
Official Symbol: F3
Synonyms: F3; coagulation factor III (thromboplastin, tissue factor); tissue factor; CD142; TF; TFA; FLJ17960;
Gene ID: 2152
mRNA Refseq: NM_001178096
Protein Refseq: NP_001171567
MIM: 134390
UniProt ID: P13726

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