Recombinant Human FBL Protein, GST-tagged

• Cat.No.: FBL-3869H
• Product Overview: Human FBL full-length ORF ( AAH19260.1, 1 a.a. - 321 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: This gene product is a component of a nucleolar small nuclear ribonucleoprotein (snRNP) particle thought to participate in the first step in processing preribosomal RNA. It is associated with the U3, U8, and U13 small nuclear RNAs and is located in the dense fibrillar component (DFC) of the nucleolus. The encoded protein contains an N-terminal repetitive domain that is rich in glycine and arginine residues, like fibrillarins in other species. Its central region resembles an RNA-binding domain and contains an RNP consensus sequence. Antisera from approximately 8% of humans with the autoimmune disease scleroderma recognize fibrillarin. [provided by RefSeq, Jul 2008]
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 61.05 kDa
• AA Sequence: MKPGFSPRGGGFGGRGGFGDRGGRG GRGGFGGGRGRGGGFRGRGRGGGGG GGGGGGGGRGGGGFHSGGNRGRGRG GKRGNQSGKNVMVEPHRHEGVFICR GKEDALVTKNLVPGESVYGEKRVSI SEGDDKIEYRAWNPFRSKLAAAILG GVDQIHIKPGAKVLYLGAASGTTVS HVSDIVGPDGLVYAVEFSHRSGRDL INLAKKRTNIIPVIEDARHPHKYRM LIAMVDVIFADVAQPDQTRIVALNA HTFLRNGGHFVISIKANCIDTTASA EAVFASEVKKMQQENMKPQEQLTLE PYERDHAVVVGVYRPPPKVKN
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: FBL fibrillarin [ Homo sapiens ]
• Official Symbol: FBL
• Synonyms: FBL; fibrillarin; rRNA 2-O-methyltransferase fibrillarin; FIB; FLRN; RNU3IP1; 34-kD nucleolar scleroderma antigen; 34 kDa nucleolar scleroderma antigen; RNA, U3 small nucleolar interacting protein 1
• Gene ID: 2091
• mRNA Refseq: NM_001436
• Protein Refseq: NP_001427
• MIM: 134795
• UniProt ID: P22087