Recombinant Human FGFR3 Protein, Fc/His-tagged
Cat.No. : | FGFR3-4135H |
Product Overview : | Human FGFR3 (NP_000133.1, 1 a.a. - 372 a.a.) partial recombinant protein with Fc-His tag expressed in HEK293E cells. |
- Specification
- Gene Information
- Related Products
Description : | This gene encodes a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia. Three alternatively spliced transcript variants that encode different protein isoforms have been described. [provided by RefSeq |
Source : | HEK293E |
Species : | Human |
Tag : | Fc/His |
Form : | Liquid |
Molecular Mass : | 66.4407 kDa |
Purity : | > 90% by SDS-PAGE |
Applications : | Functional Study SDS-PAGE |
Storage : | Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. |
Storage Buffer : | In PBS, pH 7.4. |
Gene Name : | FGFR3 fibroblast growth factor receptor 3 [ Homo sapiens ] |
Official Symbol : | FGFR3 |
Synonyms : | FGFR3; fibroblast growth factor receptor 3; ACH, achondroplasia, thanatophoric dwarfism; CD333; CEK2; JTK4; FGFR-3; tyrosine kinase JTK4; hydroxyaryl-protein kinase; ACH; HSFGFR3EX; |
Gene ID : | 2261 |
mRNA Refseq : | NM_000142 |
Protein Refseq : | NP_000133 |
MIM : | 134934 |
UniProt ID : | P22607 |
Products Types
◆ Recombinant Protein | ||
FGFR3-5419H | Recombinant Human Fibroblast Growth Factor Receptor 3, His-tagged | +Inquiry |
FGFR3-187H | Recombinant Human FGFR3 Protein, His (Fc)-Avi-tagged | +Inquiry |
Fgfr3-3003M | Recombinant Mouse Fgfr3 Protein, Myc/DDK-tagged | +Inquiry |
FGFR3-4136H | Active Recombinant Human FGFR3 Protein, GST-tagged | +Inquiry |
FGFR3-4134H | Recombinant Human FGFR3 Protein | +Inquiry |
◆ Lysates | ||
FGFR3-2596MCL | Recombinant Mouse FGFR3 cell lysate | +Inquiry |
FGFR3-001CCL | Recombinant Cynomolgus FGFR3 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionFGFR3 testing helps identify specific genetic mutations, allowing for personalized treatment plans tailored to an individual's genetic profile.
FGFR3 testing is becoming more common, especially in cases where specific cancers associated with FGFR3 mutations are suspected.
Yes, FGFR3 status can serve as a prognostic marker, influencing the prediction of disease progression and patient outcomes.
Yes, FGFR3-targeted therapies are being developed for cancer treatment, particularly for patients with FGFR3 mutations.
FGFR3-targeted therapies may involve small molecule inhibitors or monoclonal antibodies that specifically block the activity of mutated FGFR3.
Customer Reviews (3)
Write a reviewResearchers who have utilized FGFR3 protein praise its exceptional performance and reliability in their experiments.
Its high sensitivity enables the identification of low abundance targets, making it highly valuable in immunological research.
Its stability and compatibility with electron microscopy techniques make it an ideal candidate for studying protein structures at high resolution.
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