Recombinant Human GCK Protein, GST-tagged
Cat.No. : | GCK-4798H |
Product Overview : | Human GCK full-length ORF ( AAH01890, 1 a.a. - 465 a.a.) recombinant protein with GST-tag at N-terminal. |
- Specification
- Gene Information
- Related Products
Description : | Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. Alternative splicing of this gene results in three tissue-specific forms of glucokinase, one found in pancreatic islet beta cells and two found in liver. The protein localizes to the outer membrane of mitochondria. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. Mutations in this gene have been associated with non-insulin dependent diabetes mellitus (NIDDM), maturity onset diabetes of the young, type 2 (MODY2) and persistent hyperinsulinemic hypoglycemia of infancy (PHHI). [provided by RefSeq |
Source : | Wheat Germ |
Species : | Human |
Tag : | GST |
Molecular Mass : | 76.78 kDa |
AA Sequence : | MLDDRARMEAAKKEKVEQILAEFQL QEEDLKKVMRRMQKEMDRGLRLETH EEASVKMLPTYVRSTPEGSEVGDFL SLDLGGTNFRVMLVKVGEGEEGQWS VKTKHQMYSIPEDAMTGTAEMLFDY ISECISDFLDKHQMKHKKLPLGFTF SFPVRHEDIDKGILLNWTKGFKASG AEGNNVVGLLRDAIKRRGDFEMDVV AMVNDTVATMISCYYEDHQCEVGMI VGTGCNACYMEEMQNVELVEGDEGR MCVNTEWGAFGDSGELDEFLLEYDR LVDESSANPGQQLYEKLIGGKYMGE LVRLVLLRLVDENLLFHGEASEQLR TRGAFETRFVSQVESDTGDRKQIYN ILSTLGLRPSTTDCDIVRRACESVS TRAAHMCSAGLAGVINRMRESRSED VMRITVGVDGSVYKLHPSFKERFHA SVRRLTPSCEITFIESEEGSGRGAA LVSAVACKKACMLGQ |
Applications : | Enzyme-linked Immunoabsorbent Assay Western Blot (Recombinant protein) Antibody Production Protein Array |
Notes : | Best use within three months from the date of receipt of this protein. |
Storage : | Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. |
Storage Buffer : | 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
Gene Name : | GCK glucokinase (hexokinase 4) [ Homo sapiens ] |
Official Symbol : | GCK |
Synonyms : | GCK; glucokinase (hexokinase 4); maturity onset diabetes of the young 2, MODY2; glucokinase; HK4; HK IV; hexokinase-4; hexokinase-D; hexokinase type IV; hexokinase D, pancreatic isozyme; ATP:D-hexose 6-phosphotransferase; GK; GLK; HHF3; HKIV; HXKP; LGLK; MODY2; FGQTL3; |
Gene ID : | 2645 |
mRNA Refseq : | NM_000162 |
Protein Refseq : | NP_000153 |
MIM : | 138079 |
UniProt ID : | P35557 |
Products Types
◆ Recombinant Protein | ||
Gck-245M | Recombinant Mouse Gck Protein, MYC/DDK-tagged | +Inquiry |
GCK-658H | Recombinant Human GCK Protein, MYC/DDK-tagged | +Inquiry |
GCK-0260H | Recombinant Human GCK Protein (M1-Q465), Tag Free | +Inquiry |
GCK-0261H | Recombinant Human GCK Protein (M1-Q465), His tagged | +Inquiry |
GCK-2198H | Recombinant Human GCK Protein, His-tagged | +Inquiry |
◆ Lysates | ||
GCK-5985HCL | Recombinant Human GCK 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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