Recombinant Human GSR Protein, GST-tagged

• Cat.No.: GSR-4404H
• Product Overview: Human GSR full-length ORF ( NP_000628.2, 1 a.a. - 522 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: This gene encodes a member of the class-I pyridine nucleotide-disulfide oxidoreductase family. This enzyme is a homodimeric flavoprotein. It is a central enzyme of cellular antioxidant defense, and reduces oxidized glutathione disulfide (GSSG) to the sulfhydryl form GSH, which is an important cellular antioxidant. Rare mutations in this gene result in hereditary glutathione reductase deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, Aug 2010]
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 82.7 kDa
• AA Sequence: MALLPRALSAGAGPSWRRAARAFRG FLLLLPEPAALTRALSRAMACRQEP QPQGPPPAAGAVASYDYLVIGGGSG GLASARRAAELGARAAVVESHKLGG TCVNVGCVPKKVMWNTAVHSEFMHD HADYGFPSCEGKFNWRVIKEKRDAY VSRLNAIYQNNLTKSHIEIIRGHAA FTSDPKPTIEVSGKKYTAPHILIAT GGMPSTPHESQIPGASLGITSDGFF QLEELPGRSVIVGAGYIAVEMAGIL SALGSKTSLMIRHDKVLRSFDSMIS TNCTEELENAGVEVLKFSQVKEVKK TLSGLEVSMVTAVPGRLPVMTMIPD VDCLLWAIGRVPNTKDLSLNKLGIQ TDDKGHIIVDEFQNTNVKGIYAVGD VCGKALLTPVAIAAGRKLAHRLFEY KEDSKLDYNNIPTVVFSHPPIGTVG LTEDEAIHKYGIENVKTYSTSFTPM YHAVTKRKTKCVMKMVCANKEEKVV GIHMQGLGCDEMLQGFAVAVKMGAT KADFDNTVAIHPTSSEELVTLR
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -8 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: GSR glutathione reductase [ Homo sapiens ]
• Official Symbol: GSR
• Synonyms: GSR; glutathione reductase; glutathione reductase, mitochondrial; GR; GRase; MGC78522
• Gene ID: 2936
• mRNA Refseq: NM_000637
• Protein Refseq: NP_000628
• UniProt ID: P00390