Recombinant Human GSTA1 Protein, GST-tagged

• Cat.No.: GSTA1-4409H
• Product Overview: Human GSTA1 full-length ORF ( AAH53578.1, 1 a.a. - 222 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes function in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding these enzymes are known to be highly polymorphic. These genetic variations can change an individuals susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of some drugs. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-tranferase belonging to the alpha class. The alpha class genes, located in a cluster mapped to chromosome 6, are the most abundantly expressed glutathione S-transferases in liver. In addition to metabolizing bilirubin and certain anti-cancer drugs in the liver, the alpha class of these enzymes exhibit glutathione peroxidase activity thereby protecting the cells from reactive oxygen species and the products of peroxidation. [provided by RefSeq
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 50.16 kDa
• AA Sequence: MAEKPKLHYFNARGRMESTRWLLAA AGVEFEEKFIKSAEDLDKLRNDGYL MFQQVPMVEIDGMKLVQTRAILNYI ASKYNLYGKDIKERALIDMYIEGIA DLGEMILLLPVCPPEEKDAKLALIK EKIKNRYFPAFEKVLKSHGQDYLVG NKLSRADIHLVELLYYVEELDSSLI SSFPLLKALKTRISNLPTVKKFLQP GSPRKPPMDEKSLEEARKIFRF
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -8 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: GSTA1 glutathione S-transferase alpha 1 [ Homo sapiens ]
• Official Symbol: GSTA1
• Synonyms: GSTA1; glutathione S-transferase alpha 1; glutathione S transferase A1; glutathione S-transferase A1; GST-epsilon; GST HA subunit 1; GST, class alpha, 1; GST class-alpha member 1; glutathione S-transferase 2; glutathione S-aryltransferase A1; glutathione S-alkyltransferase A1; S-(hydroxyalkyl)glutathione lyase A1; glutathione S-transferase Ha subunit 1; GST2; GTH1; GSTA1-1; MGC131939
• Gene ID: 2938
• mRNA Refseq: NM_145740
• Protein Refseq: NP_665683
• MIM: 138359
• UniProt ID: P08263