Recombinant Human HMGB1, StrepII-tagged
Cat.No. : | HMGB1-255H |
Product Overview : | Purified, full-length human recombinant HMGB1 or High mobility group protein B1 protein (amino acids 2-215, 214 a.a.) with StrepII tag, produced in human cells. Predicted molecular weight: 24.8 kDa. (Accession NP_002119.1; UniProt P09429) |
- Specification
- Gene Information
- Related Products
Description : | HMGB1 is a DNA binding protein that associates with chromatin and has the ability to bend DNA. Binds preferentially single-stranded DNA. Involved in V(D)J recombination by acting as a cofactor of the RAG complex. Acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS). Heparin-binding protein that has a role in the extension of neurite-type cytoplasmic processes in developing cells. |
Source : | Human Cells |
Species : | Human |
Tag : | StrepII |
Form : | Lyophilized from sterile 0.2μm filtered solution in 0.3X PBS with 10% Trehalose (carrier-free). |
Protein length : | 2-215, 214 a.a. |
AA Sequence : | GKGDPKKPRGKMSSYAFFVQTCREE HKKKHPDASVNFSEFSKKCSERWKT MSAKEKGKFEDMAKADKARYEREMK TYIPPKGETKKKFKD PNAPKRPPSAFFLFCSEYRPKIKGE HPGLSIGDVAKKLGEMWNNTAADDK QPYEKKAAKLKEKYEKDIAAYRAKG KPDAAKKGVVKAEKSKKKKEEEEDE E DEEDEEEEEDEEDEDEEEDDDDE |
Endotoxin : | <0.1 eu per ug protein by lal |
Purity : | >95% pure by SDS-PAGE |
Storage : | 12 months at -20°C as supplied; 1 month at 4°C after reconstitution. Avoid freeze/thaw cycles. |
Reconstitution : | Centrifuge the vial prior to opening. Reconstitute in PBS to a concentration of 0.1 mg/ml. |
Gene Name : | HMGB1 high mobility group box 1 [ Homo sapiens ] |
Official Symbol : | HMGB1 |
Synonyms : | HMGB1; high mobility group box 1; high mobility group (nonhistone chromosomal) protein 1 , high mobility group box 1 , HMG1; high mobility group protein B1; Amphoterin; DKFZp686A04236; high mobility group protein 1; HMG3; SBP 1; Sulfoglucuronyl carbohydrate binding protein; HMG-1; high-mobility group box 1; high-mobility group (nonhistone chromosomal) protein 1; HMG1; SBP-1; |
Gene ID : | 3146 |
mRNA Refseq : | NM_002128 |
Protein Refseq : | NP_002119 |
MIM : | 163905 |
UniProt ID : | P09429 |
Chromosome Location : | 13q12 |
Pathway : | Activated TLR4 signalling, organism-specific biosystem; Activation of DNA fragmentation factor, organism-specific biosystem; Advanced glycosylation endproduct receptor signaling, organism-specific biosystem; Androgen Receptor Signaling Pathway, organism-specific biosystem; Apoptosis, organism-specific biosystem; Apoptosis induced DNA fragmentation, organism-specific biosystem; Apoptotic executionphase, organism-specific biosystem; |
Function : | DNA binding; DNA binding, bending; DNA binding, bending; RAGE receptor binding; calcium-dependent protein kinase regulator activity; chemoattractant activity; cytokine activity; cytokine activity; damaged DNA binding; double-stranded DNA binding; protein binding; protein kinase activator activity; repressing transcription factor binding; sequence-specific DNA binding transcription factor activity; single-stranded DNA binding; transcription factor binding; |
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HMGB1-2613H | Recombinant Human HMGB1 protein(81-200 aa), C-His-tagged | +Inquiry |
HMGB1-0716H | Recombinant Human HMGB1 Protein (M1-E215), His tagged | +Inquiry |
Hmgb1-966M | Recombinant Mouse Hmgb1 Protein, His-tagged | +Inquiry |
◆ Native Protein | ||
HMGB1-8447B | Active Native Bovine HMGB1 | +Inquiry |
◆ Lysates | ||
HMGB1-1677MCL | Recombinant Mouse HMGB1 cell lysate | +Inquiry |
HMGB1-2076HCL | Recombinant Human HMGB1 cell lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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