HMGB1
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Official Full Name
high mobility group box 1
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Overview
HMG-1 (High-Mobility-Group protein, amphoterin) is a highly conserved protein with more than 95% amino acid identity between rodent and human HMG-1. It is a prevalent non-histone chromatin component and a non-sequence specific DNA binding protein. HMG-1 consists of two homologous HMG boxes rich in basic amino acids and an acidic tail at the carboxy-terminus. HMG-1 is involved in the regulation of chromatin structure as well as being involved, either as positive or negative factors with various aspects of DNA replication, transcription, repair, and ligation. HMG-1,Identified as a membrane associated protein termed “amphoterin,” mediates neurite outgrowth, tumor outgrowth, and metastasis. It participates in plasminogen activation and is recognized as a late mediator of endotoxin lethality in mice. -
Synonyms
HMGB1; high mobility group box 1; high mobility group (nonhistone chromosomal) protein 1 , high mobility group box 1 , HMG1; high mobility group protein B1; Amphoterin; DKFZp686A04236; high mobility group protein 1; HMG3; SBP 1; Sulfoglucuronyl carbohydrate binding protein; HMG-1; high-mobility group box 1; high-mobility group (nonhistone chromosomal) protein 1; HMG1; SBP-1;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Native Proteins
- Calf
- Chicken
- Cynomolgus Monkey
- Human
- Mouse
- Rat
- Rhesus Macaque
- Calf Thymus
- CHO
- E.coli
- HEK293
- HEK293F
- HEK293T
- Hi-5 Inscet Cell
- Human Cell
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Sf9 Insect Cell
- Wheat Germ
- Yeast
- Fc
- Flag
- GST
- His
- Avi
- Myc
- MARI
- mIgG2a
- DDK
- N
- hFc
- C
- SUMO
- Non
- StrepII
- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
HMGB1 involved in several pathways and played different roles in them. We selected most pathways HMGB1 participated on our site, such as Base excision repair, which may be useful for your reference. Also, other proteins which involved in the same pathway with HMGB1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Base excision repair | PCNA;HMGB1A;APEX1;POLE2;UNG;PARP3;SMUG1;POLB;OGG1 |
HMGB1 has several biochemical functions, for example, C-X-C chemokine binding, DNA binding, bending, DNA polymerase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HMGB1 itself. We selected most functions HMGB1 had, and list some proteins which have the same functions with HMGB1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| C-X-C chemokine binding | HMGB1;CXCR6;CXCR3;CXCR7 |
| DNA binding, bending | TERF1;SRY;FOXC1;FOXD1;TOP2B;HMGB2;FOXI1;FOXL1;HMGB1 |
| DNA polymerase binding | LONP1;FANCD2;ACD;CDK2AP1;PCNA;HMGB1;RAD51;SMARCA4;FANCI |
| RAGE receptor binding | S100B;HMGB1;S100A7;S100A4;S100A13;S100A9;S100P;S100A12;HMGB2 |
| bubble DNA binding | WRN;NEIL3;ERCC5;BLM;RECQL4;HMGB1 |
| chemoattractant activity | VEGFA;SAA3;MIF;VEGFC;CCL5;FGF8;FIGF;BMP4;FGF10 |
| chromatin binding | ARID3A;RELB;SP3;RNF2;MEN1;PHF21A;POU2F1;HMGB1A;PRMT6 |
| cytokine activity | IL36G;C1QTNF4;CMTM5;IFNA7;SLURP1;NRG1;GDF6;BMP8A;GPI1 |
| damaged DNA binding | RPA3;DCLRE1C;NEIL1;GTF2H3;ERCC3;TP73;MPG;FANCG;XPC |
| double-stranded DNA binding | RAD51L3;MTERF3;XRCC3;PNKP;HMGB2;MRE11A;AIM2;SETMAR;PIN4 |
| double-stranded RNA binding | OASL1;YRDC;PRKRIP1;TUBA1B;OAS1A;OASL;IFIH1;DDX58;HMGB1 |
| four-way junction DNA binding | HMGB3;HMGB2;HMGB1;MEN1;YY1;RAD51;RAD51L3;DMC1;RAD51L1 |
| lipopolysaccharide binding | LBP;BPIFC;KIAA0644;SPON2;BPIFA2;RNASE7;PSMB4;SELP;TREM2 |
| lyase activity | CBSB;HMGB1;TSEN2;CAR13;ALDOCB;GC2;FH1;ECHDC2;ADCY1A |
| poly(A) RNA binding | PELP1;TMEM38A;TRNAU1AP;MAZ;MRPL54;EIF5B;PPIL4;DHX34;HIST1H4C |
| protein binding | TTC1;FRMPD4;CST5;TJAP1;ODF1;WIBG;NR0B1;STAG1;CASK |
| repressing transcription factor binding | HDAC1;EIF4E;MAGEA2B;ARNTL;GMNN;KAT5;HDAC7;HMGB1;MAGEA2 |
| single-stranded DNA binding | WBP11;MCM4;TDP2B;SWSAP1;RAD51L1;SSBP1;POLR2G;NABP1;C10orf2 |
| single-stranded RNA binding | CBX4;DLX2;TLR7;CNBP;DHX58;JMJD6;LONP1;ENDOV;AGO1 |
| supercoiled DNA binding | HMGB1;HMGB2;RPS3;PSIP1 |
| transcription factor activity, sequence-specific DNA binding | VAX2;NR1D4A;ZNF41;ETS1;NFE2L3;NR3C1;NOTCH1;HOXB8B;MYPOP |
| transcription factor binding | ZBTB49;DRAP1;GATA4;APBB2;MECP2;CXXC5;JUNBB;MYOCD;YWHAZ |
HMGB1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HMGB1 here. Most of them are supplied by our site. Hope this information will be useful for your research of HMGB1.
HTT; AGTRAP; MSH2; CSNK1A1
Research Area
Related articles
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Customer Reviews (3)
Write a reviewBroad storage conditions of HMGB1ins make the experimental process more stable and reliable, which provides a strong guarantee for scientific research.
I found that tHMGB1 exhibited very good stability during storage, which allowed us to perform experiments easily and obtain reliable results.
The anti-contamination ability of HMGB1 was excellent in Western blot, and the contamination problem in the experiment was avoided.
Q&As (6)
Ask a questionThis protein can promote tumor growth, invasion and angiogenesis, and plays an important role in tumor immune evasion.
Yes, HMGB1 protein plays an important role in tumor metastasis, particularly by promoting invasion of tumor cells and migration of the hematopoietic system.
Is involved in inflammatory response, vascular damage, and thrombosis in cardiovascular disease and may be associated with myocardial ischemia-reperfusion injury.
HMGB1 protein can promote the activation, chemotaxis and inflammatory response of immune cells, and is also involved in regulating the balance of autoimmune response.
HMGB1 protein is associated with processes such as chronic inflammation and insulin resistance in diabetes and may be a potential target for treatment and prevention.
The protein is involved in pathological processes such as liver fibrosis, hepatitis, and liver cancer in liver disease and may be a target for therapeutic strategies.
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