Recombinant Human HSD17B1 Protein, GST-tagged HSD17B1-5062H

Recombinant Human HSD17B1 Protein, GST-tagged

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Recombinant Human HSD17B1 Protein, GST-tagged

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Cat.No. : HSD17B1-5062H
Product Overview : Human HSD17B1 full-length ORF (BAG54583.1, 1 a.a. - 328 a.a.) recombinant protein with GST-tag at N-terminal.
Description : This gene encodes a member of the 17beta-hydroxysteroid dehydrogenase family of short-chain dehydrogenases/reductases. It has a dual function in estrogen activation and androgen inactivation and plays a major role in establishing the estrogen E2 concentration gradient between serum and peripheral tissues. The encoded protein catalyzes the last step in estrogen activation, using NADPH to convert estrogens E1 and E2 and androgens like 4-androstenedione, to testosterone. It has an N-terminal short-chain dehydrogenase domain with a cofactor binding site, and a narrow, hydrophobic C-terminal domain with a steroid substrate binding site. This gene is expressed primarily in the placenta and ovarian granulosa cells, and to a lesser extent, in the endometrium, adipose tissue, and prostate. Polymorphisms in this gene have been linked to breast and prostate cancer. A pseudogene of this gene has been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]
Source : Wheat Germ
Species : Human
Tag : GST
Molecular Mass : 61.4 kDa
AA Sequence : MARTVVLITGCSSGI GLHLAVRLASDPSQS FKVYATLRDLKTQGR LWEAARALACPPGSL ETLQLDVRDSKSVAA ARERVTEGRVDVLVC NAGLGLLGPLEALGE DAVASVLDVNVVGTV RMLQAFLPDMKRRGS GRVLVTGSVGGLMGL PFNDVYCASKFALEG LCESLAVLLLPFGVH LSLIECGPVHTAFME KVLGSPEEVLDRTDI HTFHRFYQYLAHSKQ VFREAAQNPEEVAEV FLTALRAPKPTLRYF TTERFLPLLRMRLDD PSGSNYVTAMHREVF GDVPAKAEAGAEAGG GAGPGAEDEAGRSAV GDPELGDPPAAPQ
Applications : Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
Notes : Best use within three months from the date of receipt of this protein.
Storage : Store at -8 centigrade. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Gene Name : HSD17B1 hydroxysteroid (17-beta) dehydrogenase 1 [ Homo sapiens ]
Official Symbol : HSD17B1
Synonyms : HSD17B1; hydroxysteroid (17-beta) dehydrogenase 1; EDH17B2, EDHB17; estradiol 17-beta-dehydrogenase 1; Estradiol 17 beta dehydrogenase 1; HSD17; MGC138140; SDR28C1; short chain dehydrogenase/reductase family 28CE; member 1; E2DH; 20-alpha-HSD; 17-beta-HSD 1; estradiol 17-beta-dehydrogenase-1; 20 alpha-hydroxysteroid dehydrogenase; 17-beta-hydroxysteroid dehydrogenase type 1; placental 17-beta-hydroxysteroid dehydrogenase; hydroxysteroid (17-beta) dehydrogenase 1 isoform; short chain dehydrogenase/reductase family 28CE, member 1; EDHB17; EDH17B2;
Gene ID : 3292
mRNA Refseq : NM_000413
Protein Refseq : NP_000404
MIM : 109684
UniProt ID : P14061

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