Active Recombinant Human IL7 Protein
Cat.No. : | IL7-069H |
Product Overview : | The mature recombinant human IL-7 protein consists of 152 amino acids (26-177) without tag was expressed in E. coli. |
- Specification
- Gene Information
- Related Products
Description : | The protein encoded by this gene is a cytokine important for B and T cell development. This cytokine and the hepatocyte growth factor (HGF) form a heterodimer that functions as a pre-pro-B cell growth-stimulating factor. IL7 is found to be a cofactor for V(D)J rearrangement of the T cell receptor beta (TCRB) during early T cell development. This cytokine can be produced locally by intestinal epithelial and epithelial goblet cells, and may serve as a regulatory factor for intestinal mucosal lymphocytes. IL7 plays an essential role in lymphoid cell survival, and in the maintenance of naive and memory T cells. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their presence in normal tissues has not been confirmed. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can be a potent inducer of proinflammatory cytokines and chemokines which may defend against the infection, but may also mediate destructive lung injury. Elevated serum IL7 levels, together with several other circulating cytokines and chemokines, has been found to be associated with the severity of Coronavirus Disease 19 (COVID-19). |
Source : | E. coli |
Species : | Human |
Bio-activity : | Measured in a cell proliferation assay using PHA-activated human peripheral blood lymphocytes (PBL). The ED50 for this effect is 0.1-0.5 ng/mL. |
Molecular Mass : | 17 kDa |
Product-Related Proteins : | 26-177 |
Endotoxin : | < 0.1 EU/μg of the protein as determined by the LAL method |
Purity : | > 95 % as determined by SDS-PAGE |
Storage : | At -80 centigrade. Avoid repeated freeze-thaw cycles. |
Storage Buffer : | PBS |
Gene Name : | IL7 interleukin 7 [ Homo sapiens (human) ] |
Official Symbol : | IL7 |
Synonyms : | IL7; interleukin 7; IL-7; interleukin-7 |
Gene ID : | 3574 |
mRNA Refseq : | NM_000880 |
Protein Refseq : | NP_000871 |
MIM : | 146660 |
UniProt ID : | P13232 |
Products Types
◆ Recombinant Protein | ||
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Il7-117M | Active Recombinant Mouse Il7 Protein | +Inquiry |
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IL7-5170H | Recombinant Human IL7 Protein, GST-tagged | +Inquiry |
◆ Lysates | ||
IL7-5223HCL | Recombinant Human IL7 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionIL7 is widely used in the research and development of immunotherapy protocols, can enhance the body's immune function, for the treatment of cancer, infection, autoimmune diseases and other diseases.
IL7 can activate the body's immune system and enhance the immune cells' attack on bladder cancer.
The dosage of IL7 in the treatment of leukemia needs to be calculated individually according to the specific situation of the patient.
It can enhance the function of the body's immune system, and has a certain effect on some infectious diseases.
Recombinant IL7 protein may have some therapeutic effect on specific cancers by activating T cells, but further clinical studies are needed.
This is obtained by recombinant DNA technology, inserting foreign genes into the host expression system, and then through purification and other steps.
Customer Reviews (3)
Write a reviewEffective in signal transduction pathway.
IL7 has good absorbability and high bioavailability.
Good stability under different environmental conditions
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