Il7
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Official Full Name
interleukin 7
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Overview
Interleukin 7 (IL-7) is a protein that in humans is encoded by the IL7 gene. IL-7 a hematopoietic growth factor secreted by stromal cells in the bone marrow and thymus. It is also produced by keratinocytes, dendritic cells, hepatocytes, neurons, and epithelial cells but is not produced by normal lymphocytes. -
Synonyms
IL7; Interleukin 7; IL-7; interleukin 7;
- Recombinant Proteins
- GMP Proteins
- Cell & Tissue Lysates
- Transfected Stable Cell Lines
- Protein Pre-coupled Magnetic Beads
- Bovine
- Chicken
- Human
- Mouse
- Rabbit
- Rat
- Rhesus Macaque
- CHO
- CHO-K1
- E.coli
- HEK293
- HEK293F
- Hordeum Vulgare
- Human Cell
- Human cells
- In Vitro Cell Free System
- Insect Cell
- Mammalian Cell
- Nicotiana Benthamiana
- S.cerevisiae
- Wheat Germ
- Fc
- GST
- His
- Avi
- SUMO
- HQ
- Non
- StrepII
- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
Il7 involved in several pathways and played different roles in them. We selected most pathways Il7 participated on our site, such as Cytokine-cytokine receptor interaction, PIK-Akt signaling pathway, Jak-STAT signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Il7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cytokine-cytokine receptor interaction | TNFRSF13B;IFNG;TNFRSF13C;TNFRSF10A;IL13RA1;CXCL2;KDR;IFNK;CCL24 |
| PIK-Akt signaling pathway | MAPK3;VEGFC;TLR2;FGF12;PIK3CD;PPP2R3A;PPP2R5D;ITGB7;FGF14 |
| Jak-STAT signaling pathway | PTPN11;IFNPHI3;PIM1;SOCS3B;PIAS2;GRB2;IL28A;IL2RGB;GM2002 |
| Hematopoietic cell lineage | IL11;CSF1;Itga10&Itgb1;ITGAM;GP5;IL5;CD1B;Cd24a;CD19 |
Il7 has several biochemical functions, for example, cytokine activity, growth factor activity, interleukin-7 receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Il7 itself. We selected most functions Il7 had, and list some proteins which have the same functions with Il7. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| cytokine activity | GDF7;TNFSF11;GPR19;IFNA6;CCL38A.5;GDF9;Flt3l;IL16;CD70 |
| growth factor activity | FGF14;GDF10B;FGF13B;HBEGFA;INHA;GPI;CSF1A;FGF6;NDR1 |
| interleukin-7 receptor binding | |
| protein binding | TOX4;KCNJ15;CLDN2;KRT6A;TRIP12;DOK4;APP;GPR158;ITCH |
Il7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Il7 here. Most of them are supplied by our site. Hope this information will be useful for your research of Il7.
IL7R; IL2RG
Research Area
Related articles
- Reviews
- Q&As
Customer Reviews (3)
Write a reviewEffective in signal transduction pathway.
IL7 has good absorbability and high bioavailability.
Good stability under different environmental conditions
Q&As (6)
Ask a questionIL7 is widely used in the research and development of immunotherapy protocols, can enhance the body's immune function, for the treatment of cancer, infection, autoimmune diseases and other diseases.
IL7 can activate the body's immune system and enhance the immune cells' attack on bladder cancer.
The dosage of IL7 in the treatment of leukemia needs to be calculated individually according to the specific situation of the patient.
It can enhance the function of the body's immune system, and has a certain effect on some infectious diseases.
Recombinant IL7 protein may have some therapeutic effect on specific cancers by activating T cells, but further clinical studies are needed.
This is obtained by recombinant DNA technology, inserting foreign genes into the host expression system, and then through purification and other steps.
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