Il7
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Official Full Name
interleukin 7 -
Overview
Interleukin 7 (IL-7) is a protein that in humans is encoded by the IL7 gene. IL-7 a hematopoietic growth factor secreted by stromal cells in the bone marrow and thymus. It is also produced by keratinocytes, dendritic cells, hepatocytes, neurons, and epithelial cells but is not produced by normal lymphocytes. -
Synonyms
IL7;Interleukin 7;IL-7;interleukin 7
Recombinant Proteins
- Human
- Chicken
- Mouse
- Rat
- Rhesus macaque
- Rabbit
- Bovine
- HEK293
- E.coli
- Nicotiana Benthamiana
- CHO
- Insect Cells
- Mammalian Cells
- Hordeum Vulgare
- S.Cerevisiae
- Human Cells
- In Vitro Cell Free System
- His
- Non
- Fc
- HQ
- Flag
- Avi
- SUMO
- GST
Involved Pathway
Il7 involved in several pathways and played different roles in them. We selected most pathways Il7 participated on our site, such as Cytokine-cytokine receptor interaction,PIK-Akt signaling pathway,Jak-STAT signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Il7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Jak-STAT signaling pathway | BCL2L1,MPL,SOCS1,STAT4,SOCS5,STAT5B,MCL1A,AKT2,IL3RA,IL21R |
| PIK-Akt signaling pathway | CREB5,PIK3CG,ANGPT2,PHLPP2,FGF6,KIT,MTOR,TLR4,TSC2,FGF9 |
| Hematopoietic cell lineage | TNF,CR2,GYPA,CD4,CD1d1,CSF1,CSF1R,ITGA2,CD3E,DNTT |
| Cytokine-cytokine receptor interaction | GHR,CCR1L1,CXCR2,TNFSF13,CCL15,TNFSF10,CRFB16,TNFRSF13B,Cxcl15,FLT3LG |
Protein Function
Il7 has several biochemical functions, for example, cytokine activity,growth factor activity,interleukin-7 receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Il7 itself. We selected most functions Il7 had, and list some proteins which have the same functions with Il7. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| growth factor activity | VEGFAA,BMP3,FGF11A,FGF16,CSF1B,AMELX,OSM,PDGFAA,TGFB1A,NDR2 |
| cytokine activity | INHBAA,BMP8B,RNF207B,BMP10,AREG,IFNK,GDF5,GDF15,CMTM8,CMTM6 |
| protein binding | THEG,KIAA0408,GMNN,FRMPD1,TNS3,CACNG1,LUC7L2,BLOC1S5,TPD52L3,CDK8 |
Interacting Protein
Il7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Il7 here. Most of them are supplied by our site. Hope this information will be useful for your research of Il7.
IL7R;IL2RG
Resources
Gene Families
Research Area
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References
- Bystrom, S; Ayoglu, B; et al. Affinity Proteomic Profiling of Plasma, Cerebrospinal Fluid, and Brain Tissue within Multiple Sclerosis. JOURNAL OF PROTEOME RESEARCH 13:4607-4619(2014).
- Ramdasi, AY; Arya, RP; et al. Effect of Pregnancy on Anti-HEV Antibody Titres, Plasma Cytokines and the Corresponding Gene Expression Levels in the PBMCs of Patients Presenting with Self-Recovering Clinical and Subclinical Hepatitis E. PLOS ONE 9:-(2014).
