Recombinant Human KLRC1 Protein

• Cat.No.: KLRC1-4917H
• Product Overview: Human KLRC1 full-length ORF (NP_002250.1) recombinant protein without tag.

Specification

• Description: Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. The protein encoded by this gene belongs to the killer cell lectin-like receptor family, also called NKG2 family, which is a group of transmembrane proteins preferentially expressed in NK cells. This family of proteins is characterized by the type II membrane orientation and the presence of a C-type lectin domain. This protein forms a complex with another family member, KLRD1/CD94, and has been implicated in the recognition of the MHC class I HLA-E molecules in NK cells. The genes of NKG2 family members form a killer cell lectin-like receptor gene cluster on chromosome 12. Four alternatively spliced transcript variants encoding two distinct isoforms have been observed. [provided by RefSeq
• Source: Wheat Germ
• Species: Human
• Form: Liquid
• Molecular Mass: 26.3 kDa
• AA Sequence: MDNQGVIYSDLNLPPNPKRQQRKPK GNKSSILATEQEITYAELNLQKASQ DFQGNDKTYHCKDLPSAPEKLIVGI LGIICLILMASVVTIVVIPSTLIQR HNNSSLNTRTQKARHCGHCPEEWIT YSNSCYYIGKERRTWEESLLACTSK NSSLLSIDNEEEMKFLSIISPSSWI GVFRNSSHHPWVTMNGLAFKHEIKD SDNAELNCAVLQVNRLKSAQCGSSI IYHCKHKL
• Applications: Antibody Production
  Functional Study
  Compound Screening
• Usage: Heating may cause protein aggregation. Please do not heat this product before electrophoresis.
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 25 mM Tris-HCl of pH8.0 containing 2% glycerol.

Gene Information

• Gene Name: KLRC1 killer cell lectin-like receptor subfamily C, member 1 [ Homo sapiens ]
• Official Symbol: KLRC1
• Synonyms: KLRC1; killer cell lectin-like receptor subfamily C, member 1; NKG2; NKG2-A/NKG2-B type II integral membrane protein; CD159a; NKG2 1/B activating NK receptor; NKG2 A; NKG2 B; NK cell receptor A; C-lectin type II protein; natural killer cell lectin; natural killer group protein 2; NKG2-1/B activating NK receptor; NKG2-A/B-activating NK receptor; CD159 antigen-like family member A; NKG2-A/B type II integral membrane protein; NKG2A; CD159A; MGC13374; MGC59791
• Gene ID: 3821
• mRNA Refseq: NM_002259
• Protein Refseq: NP_002250
• MIM: 161555
• UniProt ID: P26715