Recombinant Human LBP Protein, His-tagged
Cat.No. : | LBP-007H |
Product Overview : | Recombinant human LBP, fused to His-tag at C-terminus, was expressed in HEK293 cell and purified by using conventional chromatography techniques. |
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Description : | The protein encoded by this gene is involved in the acute-phase immunologic response to gram-negative bacterial infections. Gram-negative bacteria contain a glycolipid, lipopolysaccharide (LPS), on their outer cell wall. Together with bactericidal permeability-increasing protein (BPI), the encoded protein binds LPS and interacts with the CD14 receptor, probably playing a role in regulating LPS-dependent monocyte responses. Studies in mice suggest that the encoded protein is necessary for the rapid acute-phase response to LPS but not for the clearance of LPS from circulation. This protein is part of a family of structurally and functionally related proteins, including BPI, plasma cholesteryl ester transfer protein (CETP), and phospholipid transfer protein (PLTP). |
Source : | HEK293 |
Species : | Human |
Tag : | His |
Form : | Liquid |
Molecular Mass : | 51.7 kDa |
AA Sequence : | ANPGLVARITDKGLQYAAQEGLLAL QSELLRITLPDFTGDLRIPHVGRGR YEFHSLNIHSCELLHSALRPVPGQG LSLSISDSSIRVQGRWKVRKSFFKL QGSFDVSVKGISISVNLLLGSESSG RPTVTASSCSSDIADVEVDMSGDLG WLLNLFHNQIESKFQKVLESRICEM IQKSVSSDLQPYLQTLPVTTEIDSF ADIDYSLVEAPRATAQMLEVMFKGE IFHRNHRSPVTLLAAVMSLPEEHNK MVYFAISDYVFNTASLVYHEEGYLN FSITDDMIPPDSNIRLTTKSFRPFV PRLARLYPNMNLELQGSVPSAPLLN FSPGNLSVDPYMEIDAFVLLPSSSK EPVFRLSVATNVSATLTFNTSKITG FLKPGKVKVELKESKVGLFNAELLE ALLNYYILNTFYPKFNDKLAEGFPL PLLKRVQLYDLGLQIHKDFLFLGAN VQYMRV |
Endotoxin : | < 1 EU/μg of protein (determined by LAL method) |
Purity : | > 95% by SDS-PAGE |
Applications : | SDS-PAGE |
Storage : | Can be stored at +2 to +8 centigrade for 1 week. For long term storage, aliquot and store at -20 to -86 centigrade. Avoid repeated freezing and thawing cycles. |
Concentration : | 0.25 mg/mL (determined by absorbance at 280nm) |
Storage Buffer : | Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol |
Gene Name : | LBP lipopolysaccharide binding protein [ Homo sapiens (human) ] |
Official Symbol : | LBP |
Synonyms : | LBP; lipopolysaccharide binding protein; BPIFD2; lipopolysaccharide-binding protein; BPI fold containing family D, member 2; LPS-binding protein |
Gene ID : | 3929 |
mRNA Refseq : | NM_004139 |
Protein Refseq : | NP_004130.2 |
MIM : | 151990 |
UniProt ID : | P18428 |
Products Types
◆ Recombinant Protein | ||
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LBP-4447H | Recombinant Human LBP Protein, His (Fc)-Avi-tagged | +Inquiry |
Lbp-5009M | Recombinant Mouse Lbp Protein, His (Fc)-Avi-tagged | +Inquiry |
Lbp-5007M | Recombinant Mouse Lbp Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
LBP-1853HCL | Recombinant Human LBP cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionIf LPS's chemical spatial configuration prevents close contact with TLR4, it exhibits an antagonistic effect, inhibiting the cellular response.
LPS on the LBP-LPS complex, upon close physical contact with TLR4 on cells, induces TLR4 receptor dimerization or multimerization. This activates various transcription factors, leading to the expression of inflammatory mediators and cytokines.
For cells without membrane CD14 receptors (e.g., endothelial and epithelial cells), a soluble CD14 (sCD14)-LBP-LPS ternary complex forms, activating TLR4 and inducing various biological effects.
LBP stands for Lipopolysaccharide-Binding Protein.
LBP has a high affinity for the lipid A portion in the structure of Lipopolysaccharide (LPS) and forms the LPS-LBP complex.
Liver cells, similar to macrophages, express mCD14 and TLR4. In the absence of CD14 receptors, LPS can still bind to TLR4, but with relatively weaker intensity.
The LBP-LPS complex can transfer LPS to membrane CD14 (mCD14) receptors on cells like monocytes, macrophages, and neutrophils.
Customer Reviews (3)
Write a reviewWe appreciated the product's efforts to minimize its environmental footprint through sustainable manufacturing practices.
Its adaptability to various sample types and conditions made it a valuable asset for our diverse projects.
The product's versatility allowed us to apply it to a wide range of experimental techniques and research areas.
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