Recombinant Human MYOC Protein, GST-tagged

• Cat.No.: MYOC-5849H
• Product Overview: Human MYOC full-length ORF ( AAH29261, 1 a.a. - 504 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: MYOC encodes the protein myocilin, which is believed to have a role in cytoskeletal function. MYOC is expressed in many occular tissues, including the trabecular meshwork, and was revealed to be the trabecular meshwork glucocorticoid-inducible response protein (TIGR). The trabecular meshwork is a specialized eye tissue essential in regulating intraocular pressure, and mutations in MYOC have been identified as the cause of hereditary juvenile-onset open-angle glaucoma. [provided by RefSeq
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 81.18 kDa
• AA Sequence: MRFFCARCCSFGPEMPAVQLLLLAC LVWDVGARTAQLRKANDQSGRCQYT FSVASPNESSCPEQSQAMSVIHNLQ RDSSTQRLDLEATKARLSSLESLLH QLTLDQAARPQETQEGLQRELGTLR RERDQLETQTRELETAYSNLLRDKS VLEEEKKRLRQENENLARRLESSSQ EVARLRRGQCPQTRDTARAVPPGSR EVSTWNLDTLAFQELKSELTEVPAS RILKESPSGYLRSGEGDTGCGELVW VGEPLTLRTAETITGKYGVWMRDPK PTYPYTQETTWRIDTVGTDVRQVFE YDLISQFMQGYPSKVHILPRPLEST GAVVYSGSLYFQGAESRTVIRYELN TETVKAEKEIPGAGYHGQFPYSWGG YTDIDLAVDEAGLWVIYSTDEAKGA IVLSKLNPENLELEQTWETNIRKQS VANAFIICGTLYTVSSYTSADATVN FAYDTGTGISKTLTIPFKNRYKYSS MIDYNPLEKKLFAWDNLNMVTYDIK LSKM
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: MYOC myocilin, trabecular meshwork inducible glucocorticoid response [ Homo sapiens ]
• Official Symbol: MYOC
• Synonyms: MYOC; myocilin, trabecular meshwork inducible glucocorticoid response; GLC1A; myocilin; JOAG1; TIGR; mutated trabecular meshwork-induced glucocorticoid response protein; GPOA; JOAG
• Gene ID: 4653
• mRNA Refseq: NM_000261
• Protein Refseq: NP_000252
• MIM: 601652
• UniProt ID: Q99972