Recombinant Human PCSK9 Protein, Strep-tagged

Cat.No. : PCSK9-411H
Product Overview : Recombinant human PCSK9 protein with Strep tag was expressed in HEK293.
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Description : This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an autocatalytic processing event with its prosegment in the ER and is constitutively secreted as an inactive protease into the extracellular matrix and trans-Golgi network. It is expressed in liver, intestine and kidney tissues and escorts specific receptors for lysosomal degradation. It plays a role in cholesterol and fatty acid metabolism. Mutations in this gene have been associated with autosomal dominant familial hypercholesterolemia. Alternative splicing results in multiple transcript variants.
Source : HEK293
Species : Human
Tag : Strep
Form : Lyophilized
Molecular Mass : 73.5 kDa
Protein Length : 692
AA Sequence : MGTVSSRRSWWPLPLLLLLLLLLGP AGARAQEDEDGDYEELVLALRSEED GLAEAPEHGTTATFHRCAKDPWRLP GTYVVVLKEETHLSQSERTARRLQA QAARRGYLTKILHVFHGLLPGFLVK MSGDLLELALKLPHVDYIEEDSSVF AQSIPWNLERITPPRYRADEYQPPD GGSLVEVYLLDTSIQSDHREIEGRV MVTDFENVPEEDGTRFHRQASKCDS HGTHLAGVVSGRDAGVAKGASMRSL RVLNCQGKGTVSGTLIGLEFIRKSQ LVQPVGPLVVLLPLAGGYSRVLNAA CQRLARAGVVLVTAAGNFRDDACLY SPASAPEVITVGATNAQDQPVTLGT LGTNFGRCVDLFAPGEDIIGASSDC STCFVSQSGTSQAAAHVAGIAAMML SAEPELTLAELRQRLIHFSAKDVIN EAWFPEDQRVLTPNLVAALPPSTHG AGWQLFCRTVWSAHSGPTRMATAVA RCAPDEELLSCSSFSRSGKRRGERM EAQGGKLVCRAHNAFGGEGVYAIAR CCLLPQANCSVHTAPPAEASMGTRV HCHQQGHVLTGCSSHWEVEDLGTHK PPVLRPRGQPNQCVGHREASIHASC CHAPGLECKVKEHGIPAPQEQVTVA CEEGWTLTGCSALPGTSHVLGAYAV DNTCVVRSRDVSTTGSTSEGAVTAV AICCRSRHLAQASQELQ
Purity : > 98%
Applications : WB; ELISA; FACS; FC
Stability : This bioreagent is stable at 4 centigrade (short-term) and -70 centigrade(long-term). After reconstitution, sample may be stored at 4 centigrade for 2-7 days and below -18 centigrade for future use.
Storage : At -20 centigrade.
Concentration : 1 mg/mL
Storage Buffer : PBS (pH 7.4-7.5). Sterile-filtered colorless solution.
Reconstitution : Reconstitute in sterile distilled H2O to no less than 100 μg/mL; dilute reconstituted stock further in other aqueous solutions if needed. Please review COA for lot-specific instructions. Final measurements should be determined by the end-user for optimal performance.
Gene Name : PCSK9 proprotein convertase subtilisin/kexin type 9 [ Homo sapiens (human) ]
Official Symbol : PCSK9
Synonyms : PCSK9; proprotein convertase subtilisin/kexin type 9; HCHOLA3, hypercholesterolemia, autosomal dominant 3; FH3; NARC 1; NARC1; NARC-1; HCHOLA3;
Gene ID : 255738
mRNA Refseq : NM_174936
Protein Refseq : NP_777596
MIM : 607786
UniProt ID : Q8NBP7

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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Is there a relationship between genetic mutations in the PCSK9 protein and cardiovascular disease? 12/30/2019

Yes, some studies suggest that mutations in the PCSK9 protein gene may increase the risk of cardiovascular disease. For example, some PCSK9 mutations can cause their dysfunction, resulting in hypercholesterolemia and cardiovascular disease.

How can PCSK9 protein be used for vaccine development? 12/17/2019

PCSK9 protein is combined with immune adjuvants to make a vaccine, or mutated PCSK9 protein to induce an immune response to it, inhibit PCSK9 expression in vivo, increase LDLR levels and reduce serum cholesterol levels.

What is the relationship between PCSK9 protein and obesity? 07/23/2019

This protein may have a regulatory effect on weight and obesity, and it is associated with glucose and endocannabinin homeostasis studies have linked PCSK9 to the development of obesity and diabetes.

What are the new prospects for future therapies that inhibit PCSK9 protein? 06/26/2019

Several new anti-PCSK9 drugs are already being studied and developed, including oral drugs and gene chromosome therapies, and some drugs have advanced to early stages of clinical trials, providing new options for the treatment of PCSK9 proteins.

What drugs are currently available to inhibit the PCSK9 protein? 05/08/2019

Currently on the market to inhibit PCSK9 protein drugs include alirocumab and evolocumab.

What is the relationship between PCSK9 protein and hypercholesterolemia? 01/11/2019

PCSK9 protein can degrade LDLR protein, so its overexpression will lead to a decrease in LDLR's ability to be cleared, leading to hypercholesterolemia.

Customer Reviews (3)

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Reviews
11/13/2022

    In immunological experiments, it was found that it had good antigenicity and could induce target immune responses.

    07/07/2022

      It promoted cell growth and proliferation.

      03/04/2022

        High catalytic efficiency.

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