| Description : |
This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an autocatalytic processing event with its prosegment in the ER and is constitutively secreted as an inactive protease into the extracellular matrix and trans-Golgi network. It is expressed in liver, intestine and kidney tissues and escorts specific receptors for lysosomal degradation. It plays a role in cholesterol and fatty acid metabolism. Mutations in this gene have been associated with autosomal dominant familial hypercholesterolemia. Alternative splicing results in multiple transcript variants. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Strep |
| Form : |
Lyophilized |
| Molecular Mass : |
73.5 kDa |
| Protein Length : |
692 |
| AA Sequence : |
MGTVSSRRSWWPLPLLLLLLLLLGP AGARAQEDEDGDYEELVLALRSEED GLAEAPEHGTTATFHRCAKDPWRLP GTYVVVLKEETHLSQSERTARRLQA QAARRGYLTKILHVFHGLLPGFLVK MSGDLLELALKLPHVDYIEEDSSVF AQSIPWNLERITPPRYRADEYQPPD GGSLVEVYLLDTSIQSDHREIEGRV MVTDFENVPEEDGTRFHRQASKCDS HGTHLAGVVSGRDAGVAKGASMRSL RVLNCQGKGTVSGTLIGLEFIRKSQ LVQPVGPLVVLLPLAGGYSRVLNAA CQRLARAGVVLVTAAGNFRDDACLY SPASAPEVITVGATNAQDQPVTLGT LGTNFGRCVDLFAPGEDIIGASSDC STCFVSQSGTSQAAAHVAGIAAMML SAEPELTLAELRQRLIHFSAKDVIN EAWFPEDQRVLTPNLVAALPPSTHG AGWQLFCRTVWSAHSGPTRMATAVA RCAPDEELLSCSSFSRSGKRRGERM EAQGGKLVCRAHNAFGGEGVYAIAR CCLLPQANCSVHTAPPAEASMGTRV HCHQQGHVLTGCSSHWEVEDLGTHK PPVLRPRGQPNQCVGHREASIHASC CHAPGLECKVKEHGIPAPQEQVTVA CEEGWTLTGCSALPGTSHVLGAYAV DNTCVVRSRDVSTTGSTSEGAVTAV AICCRSRHLAQASQELQ |
| Purity : |
> 98% |
| Applications : |
WB; ELISA; FACS; FC |
| Stability : |
This bioreagent is stable at 4 centigrade (short-term) and -70 centigrade(long-term). After reconstitution, sample may be stored at 4 centigrade for 2-7 days and below -18 centigrade for future use. |
| Storage : |
At -20 centigrade. |
| Concentration : |
1 mg/mL |
| Storage Buffer : |
PBS (pH 7.4-7.5). Sterile-filtered colorless solution. |
| Reconstitution : |
Reconstitute in sterile distilled H2O to no less than 100 μg/mL; dilute reconstituted stock further in other aqueous solutions if needed. Please review COA for lot-specific instructions. Final measurements should be determined by the end-user for optimal performance. |
