pcsk9
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  • Official Full Name
  • proprotein convertase subtilisin/kexin type 9
  • Background
  • This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an autocatalytic processing event with its prosegment in the ER and is constitutively secreted as an inactive protease into the extracellular matrix and trans-Golgi network. It is expressed in liver, intestine and kidney tissues and escorts specific receptors for lysosomal degradation. It plays a role in cholesterol and fatty acid metabolism. Mutations in this gene have been associated with autosomal dominant familial hypercholesterolemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
  • Synonyms
  • PCSK9; proprotein convertase subtilisin/kexin type 9; FH3; PC9; NARC1; LDLCQ1; NARC-1; HCHOLA3; subtilisin/kexin-like protease PC9; neural apoptosis regulated convertase 1; convertase subtilisin/kexin type 9 preproprotein;
Cat.#:PCSK9-86HTag:His
Source (Host):NS0Species:Human
Product nameRecombinant Human PCSK9 Protein, His-tagged
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Cat.#:Pcsk9-209MTag:His-Avi
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Pcsk9 Protein, His-Avi-tagged, Biotinylated
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Cat.#:PCSK9-350HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human PCSK9 Protein, Fc-tagged
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Cat.#:PCSK9-351HTag:Strep
Source (Host):HEK293Species:Human
Product nameRecombinant Human PCSK9 Protein, Strep-tagged
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Cat.#:PCSK9-352HTag:His & Avi
Source (Host):HEK293Species:Human
Product nameRecombinant Human PCSK9 Protein, His & Avi-tagged, Biotinylated
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Cat.#:PCSK9-486RTag:MIgG1 Fc
Source (Host):HEK293Species:Rhesus
Product nameRecombinant Rhesus PCSK9 Protein (Met1-Gln692), MIgG1 Fc-tagged
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Cat.#:PCSK9-692HTag:MIgG1 Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human PCSK9 Protein (Met1-Gln692), MIgG1 Fc-tagged
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Cat.#:PCSK9-812MTag:MlgG1 Fc
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse PCSK9 Protein (Met1-Gln694), MlgG1 Fc-tagged
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Cat.#:PCSK9-2137HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human PCSK9 Protein, His-tagged
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Cat.#:PCSK9-1154HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PCSK9 protein, His-tagged
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Cat.#:PCSK9-153HTag:His, HA & AVI
Source (Host):HEK293Species:Human
Product nameRecombinant Human PCSK9, HIS/HA/AVI-tagged
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Cat.#:PCSK9-168HTag:DDK/His
Source (Host):HEK293 cellsSpecies:Human
Product nameRecombinant Human PCSK9 Protein, DDK/HIS-tagged
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Cat.#:PCSK9-169HTag:HIS
Source (Host):CHO cellsSpecies:Human
Product nameRecombinant Human PCSK9 Protein, HIS-tagged
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Cat.#:PCSK9-186HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human PCSK9, His-tagged, Biotinylated
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Cat.#:PCSK9-187HTag:His/AVI
Source (Host):HEK293Species:Human
Product nameRecombinant Human PCSK9 Protein, His & Avi-tagged, Biotinylated
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Cat.#:PCSK9-201HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human PCSK9, His-tagged, C13&N15 Labeled
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Cat.#:PCSK9-212HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human PCSK9, His-tagged
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Cat.#:PCSK9-242HTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human PCSK9, C13&N15-labeled
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Cat.#:PCSK9-312HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human PCSK9, His tagged
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Cat.#:PCSK9-643HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human PCSK9, His-tagged
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Cat.#:Pcsk9-1155MTag:His/GST
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Pcsk9 protein, His & GST-tagged
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Cat.#:Pcsk9-197MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Pcsk9, His-tagged, C13&N15 Labeled
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Cat.#:Pcsk9-208MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Pcsk9, His-tagged
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Cat.#:Pcsk9-243MTag:N/A
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Pcsk9, C13&N15-labeled
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Cat.#:Pcsk9-259MTag:His
Source (Host):NS0Species:Mouse
Product nameRecombinant Mouse Pcsk9 protein, His-tagged
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Cat.#:Pcsk9-663MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Pcsk9, His tagged
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Cat.#:Pcsk9-1156RTag:His/GST
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Pcsk9 protein, His & GST-tagged
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Cat.#:PCSK9-4311RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PCSK9 Protein
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Cat.#:Pcsk9-915RTag:His
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat Pcsk9, His tagged
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Cat.#:PCSK9-358CTag:His
Source (Host):HEK293Species:Cynomolgus
Product nameRecombinant Cynomolgus PCSK9 protein, His-tagged
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Cat.#:PCSK9-311RTag:His
Source (Host):HEK293Species:Rhesus Macaque
Product nameRecombinant Rhesus PCSK9, His tagged
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Cat.#:PCSK9-3334RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey PCSK9 Protein, His-tagged
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Cat.#:PCSK9-313HTag:His
Source (Host):HEK293Species:Hamster
Product nameRecombinant Hamster PCSK9 Protein, His-tagged
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Cat.#:PCSK9-2875HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human PCSK9 cell lysate
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Cat.#:PCSK9-2564MCLTag:
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse PCSK9 cell lysate
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Cat.#:PCSK9-2306RCLTag:
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat PCSK9 cell lysate
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Cat.#:PCSK9-2775RCLTag:
Source (Host):HEK293Species:Rhesus Macaque
Product nameRecombinant Rhesus PCSK9 cell lysate
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Cat.#:Kit-1806Tag:
Source (Host):Species:
Product namePCSK9(D374T)-LDLR TR-FRET Assay Kit
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Cat.#:Kit-1807Tag:
Source (Host):Species:
Product namePCSK9[Biotinylated]-LDLR Binding Assay Kit
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Cat.#:Kit-1808Tag:
Source (Host):Species:
Product namePCSK9-LDLR TR-FRET Assay Kit
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Cat.#:Kit-0665Tag:
Source (Host):Species:
Product namePCSK9-BIRC2 in vitro Binding Assay Kit
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Cat.#:Kit-0666Tag:
Source (Host):Species:
Product namePCSK9-LDLR in vitro Binding Assay Kit
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Protein Function

Pcsk9 has several biochemical functions, for example, apolipoprotein binding, apolipoprotein receptor binding, low-density lipoprotein particle binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Pcsk9 itself. We selected most functions Pcsk9 had, and list some proteins which have the same functions with Pcsk9. You can find most of the proteins on our site.
Function
Related Protein
Function apolipoprotein binding
Related Protein LRP1; LPL; LRP6; PCSK9; MAPT; CANX; LPA; LRP4; ABCA1; SCARB1
Function apolipoprotein receptor binding
Related Protein APOA1; APOA2; PCSK9
Function low-density lipoprotein particle binding
Related Protein COLEC12; CRP; LIPC; ANKRA2; LDLR; SCARB1; CDH13; SORL1; THBS1; PCSK9
Function low-density lipoprotein particle receptor binding
Related Protein SYT1; DNAJA1; LRPAP1; LDLRAP1; APOE; APOB; SNX17; APOEA; SACS; CRP
Function poly(A) RNA binding
Related Protein CPEB3; CIRBP; SF3A2; NXF2; TARDBP; MRPL14; FNDC3A; PEG10; SLIRP; RPSA
Function protein binding
Related Protein KIF18B; TDO2; CAV3; CDK11B; EIF5A; C10orf28; PFTK1; RTN4R; RHOT2; JAM3
Function protein self-association
Related Protein SLC2A1; ADAM8; MALT1; CTSB; TNFAIP3; VAMP2; RYR2; CTSC; TMEM190; PTH1R
Function receptor inhibitor activity
Related Protein PCSK9
Function serine-type endopeptidase activity
Related Protein PROCA; PRSS30; PRSS12; TPSAB1; PARL; PRSS2; C1RL; HGF; Gzmg; TMPRSS11F
Function sodium channel inhibitor activity
Related Protein NEDD4; PCSK9; NEDD4L; SCN1B; CAMK2D; SLC14A2
Function very-low-density lipoprotein particle binding
Related Protein VLDLR; PCSK9
Function very-low-density lipoprotein particle receptor binding
Related Protein APOEA; LRPAP1; APOEB; Reln; PCSK9; APOE

Interacting Protein

Pcsk9 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Pcsk9 here. Most of them are supplied by our site. Hope this information will be useful for your research of Pcsk9.
LDLR; MMP2; ANXA2

Pcsk9 Related Articles

Shapiro, MD; Fazio, S; et al. Targeting PCSK9 for Therapeutic Gains. CURRENT ATHEROSCLEROSIS REPORTS 17:-(2015).
Tavori, H; Giunzioni, I; et al. PCSK9 inhibition to reduce cardiovascular disease risk: recent findings from the biology of PCSK9. CURRENT OPINION IN ENDOCRINOLOGY DIABETES AND OBESITY 22:126-132(2015).