Pcsk9

  • Official Full Name

    proprotein convertase subtilisin/kexin type 9

  • Overview

    This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an autocatalytic processing event with its prosegment in the ER and is constitutively secreted as an inactive protease into the extracellular matrix and trans-Golgi network. It is expressed in liver, intestine and kidney tissues and escorts specific receptors for lysosomal degradation. It plays a role in cholesterol and fatty acid metabolism. Mutations in this gene have been associated with autosomal dominant familial hypercholesterolemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
  • Synonyms

    PCSK9; proprotein convertase subtilisin/kexin type 9; FH3; PC9; NARC1; LDLCQ1; NARC-1; HCHOLA3; subtilisin/kexin-like protease PC9; neural apoptosis regulated convertase 1; convertase subtilisin/kexin type 9 preproprotein;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chromatography Reagents
  • Assay Kits
  • Chinese hamster
  • Cynomolgus
  • Cynomolgus monkey
  • Hamster
  • Human
  • Macaca mulatta (Rhesus macaque)
  • Mouse
  • Rat
  • Rhesus
  • Rhesus macaque
  • Rhesus Macaque
  • CHO
  • E.coli
  • HEK293
  • HEK293 cells
  • HEK293T
  • Human Cell
  • Mammalian Cell
  • Mammalian cells
  • Avi
  • His
  • C
  • AVI
  • HA
  • Myc
  • DDK
  • DDK|His
  • Fc
  • Flag
  • HIS
  • His (Fc)
  • His(C
  • ter)
  • His\HA\Avi
  • His|Avi
  • His|GST
  • His|HA|Avi
  • human|IgG1|Fc
  • mFc
  • MIgG1 Fc
  • MlgG1 Fc
  • MYC
  • N/A
  • N
  • Strep
  • Tag Free
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PCSK9-169H Active Recombinant Human PCSK9 Protein, HIS-tagged CHO HIS
Human PCSK9-186H Active Recombinant Human PCSK9, His-tagged, Biotinylated HEK293 His
Human PCSK9-187H Active Recombinant Human PCSK9 protein, Avi-His-tagged, Biotinylated HEK293 Avi-His Gln 31 - Gln 692(D374Y)
Human PCSK9-184H Active Recombinant Human PCSK9 protein(Met1-Gln692), His-tagged HEK293 C-His Met1-Gln692
Human PCSK9-352H Active Recombinant Human PCSK9 Protein, His & Avi-tagged, Biotinylated HEK293 His/Avi Gln 31 - Gln 692
Human PCSK9-312H Recombinant Human PCSK9 protein(Met1-Gln692), His-tagged HEK293 C-His Met1-Gln692
Human PCSK9-1154H Recombinant Human PCSK9 protein, His-tagged E.coli His Trp156~Trp461 (Accession # Q8NBP7)
Human PCSK9-86H Active Recombinant Human PCSK9 Protein, His-tagged Mammalian cells His
Human PCSK9-242H Recombinant Human PCSK9, C13&N15-labeled HEK293 N/A
Human PCSK9-643H Recombinant Human Mature PCSK9 protein, His-tagged HEK293 His Ser153-Gln692
Human PCSK9-153H Recombinant Human PCSK9, HIS/HA/AVI-tagged HEK293 His/HA/Avi
Human PCSK9-201H Recombinant Human PCSK9, His-tagged, C13&N15 Labeled HEK293 His
Human PCSK9-168H Recombinant Human PCSK9 Protein, DDK/HIS-tagged HEK293 DDK/His
Human PCSK9-2875HCL Recombinant Human PCSK9 cell lysate Human Cell N/A
Human PCSK9-035H Recombinant Human PCSK9 Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
Human PCSK9-203H Recombinant Human PCSK9 Protein, GLN31-GLN692, Tag Free, Biotinylated HEK293 Tag Free GLN31-GLN692
Human PCSK9-692H Recombinant Human PCSK9 protein, mFc-tagged HEK293 mFc Met1-Gln692
Human PCSK9-005H Active Recombinant Human PCSK9 Protein, His-tagged HEK293 His 31-692
Human PCSK9-185HB Recombinant Human PCSK9 protein (Val474Ile, Gly670Glu), His-tagged, Biotinylated HEK293 His
Human PCSK9-5859H Recombinant Human PCSK9 Protein (Met1-Gln692), C-His tagged Mammalian cells C-His Met1-Gln692
Human PCSK9-02H Recombinant Human PCSK9 Protein, His-tagged E.coli His 1-692
Human PCSK9-03H Active Recombinant Human PCSK9 Protein, His-tagged HEK293 His
Human PCSK9-184HB Recombinant Human PCSK9 protein (Asp374Tyr, Val474Ile, Gly670Glu), His-tagged, Biotinylated HEK293 His
Human PCSK9-804H Recombinant Human PCSK9 Protein, His-tagged HEK293 His Full
Human PCSK9-312HB Recombinant Human PCSK9 protein, His-tagged, Biotinylated HEK293 His
Human PCSK9-2138HB Recombinant Human PCSK9 protein, mFc-tagged, Biotinylated HEK293 mFc Met1-Gln692(D374Y)
Human PCSK9-350H Recombinant Human PCSK9 protein, Fc-tagged HEK293 human/IgG1/Fc 662
Human PCSK9-1622H-B Recombinant Human PCSK9 Protein Pre-coupled Magnetic Beads HEK293
Human PCSK9-041H Active Recombinant Human PCSK9 Protein, His-tagged HEK293 His 1-692
Human PCSK9-040H Active Recombinant Human PCSK9 Protein, His-tagged HEK293 His 1-692
Human PCSK9-351H Recombinant Human PCSK9 protein, Strep-tagged HEK293 Strep 662
Human PCSK9-2137H Recombinant Human PCSK9 (D374Y) protein, His-tagged HEK293 His Gln31-Gln692
Human PCSK9-205H Recombinant Human PCSK9 Protein, Avi-tagged Human Cell Avi
Human PCSK9-289H Recombinant Human PCSK9 (R194A) protein, His-tagged HEK293 His Gln31-Gln692
Human PCSK9-2138H Recombinant Human PCSK9 protein (Met1-Gln692(D374Y)), mFc-tagged HEK293 mFc
Human PCSK9-135H Recombinant Human PCSK9 Protein, His-tagged HEK293 His 31-692
Human PCSK9-1622H Recombinant Human PCSK9 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human PCSK9-01H Recombinant Human PCSK9 Protein, His-tagged HEK293 cells His 1-692
Human PCSK9-407H Recombinant Human PCSK9 Protein, His-tagged HEK293 His 692
Human PCSK9-353H Recombinant Human PCSK9(Gln31-Gln692(Val474Ile,Gly670Glu)) Protein, C-Avi-tagged, Biotinylated HEK293 Avi
Human PCSK9-3811H Recombinant Human PCSK9 Protein (Gln31-Gln152, Ser153-Gln692), C-His tagged Mammalian cells C-His Gln31-Gln152, Ser153-Gln692
Human PCSK9-411H Recombinant Human PCSK9 Protein, Strep-tagged HEK293 Strep 692
Human PCSK9-408H Recombinant Human PCSK9 Protein, His-tagged HEK293 His 692
Human PCSK9-33H Recombinant Human PCSK9 Protein, C-AVI tagged, Biotinylated Human Cell C-AVI Gln31-Gln692(Val474Ile, Gly670Glu)
Human PCSK9-3813H Recombinant Human PCSK9 Protein (Met1-Asn692), C-His tagged Mammalian cells C-His Met1-Asn692
Human PCSK915495H Recombinant Human PCSK9 (30-692) Protein
Human PCSK9-409H Recombinant Human PCSK9 Protein, His-tagged HEK293 His Full
Human PCSK9-34H Recombinant Human PCSK9 Protein, C-His&HA&AVI tagged, Biotinylated Human Cell C-His&HA&AVI Gln31-Gln692(Val474Ile, Gly670Glu)
Human PCSK9-410H Recombinant Human PCSK9 Protein, His-tagged HEK293 His 692
Human PCSK9-13H Recombinant Human CSK9 Protein (31-692), C-His-Avi-Tagged, Biotin-Labeled HEK293 C-His-Avi 31-692 (end)
Human PCSK931784H Recombinant Human PCSK9 (61-692) Protein
Human PCSK9-264H Recombinant Human PCSK9 Protein, His-tagged(C-ter) HEK293 His(C-ter) Gln31-Gln692
Human PCSK9-0639H Active Recombinant Human PCSK9 protein, Fc-tagged HEK293 Fc Gln31-Gln692
Human PCSK9-3809H Recombinant Human PCSK9 Protein (Gln31-Gln152, Ser153-Gln692), C-His/HA/AVI tagged, Biotinylated Mammalian cells C-His/HA/AVI Gln31-Gln152, Ser153-Gln692
Human PCSK9-3808H Recombinant Human PCSK9 Protein (Gln31-Gln152, Ser153-Gln692), C-AVI tagged, Biotinylated Mammalian cells C-AVI Gln31-Gln152, Ser153-Gln692
Human PCSK9-206H Recombinant Human PCSK9 Protein, His\HA\Avi-tagged Human Cell His\HA\Avi
Human PCSK9-3273H Recombinant Human PCSK9 protein(Met1-Gln692), His-tagged, Biotinylated HEK293 C-His Met1-Gln692
Human PCSK9-3812H Recombinant Human PCSK9 Protein (Gln31-Gln692), N-His tagged E.coli N-His Gln31-Gln692
Human PCSK9-1321HFL Recombinant Full Length Human PCSK9 Protein, C-Flag-tagged Mammalian cells Flag
Human PCSK9-765M PCSK9 protein-coupled magnetic Beads
Mouse Pcsk9-259M Active Recombinant Mouse Pcsk9 protein, His-tagged Mammalian cells His
Mouse Pcsk9-663M Recombinant Mouse Pcsk9 protein, His-tagged HEK293 His Gln35-Gln694
Mouse Pcsk9-243M Recombinant Mouse Pcsk9, C13&N15-labeled HEK293 N/A
Mouse Pcsk9-197M Recombinant Mouse Pcsk9, His-tagged, C13&N15 Labeled HEK293 His
Mouse Pcsk9-1155M Recombinant Mouse Pcsk9 protein, His & GST-tagged E.coli His/GST Ser156~Gln694 (Accession # Q80W65)
Mouse PCSK9-2564MCL Recombinant Mouse PCSK9 cell lysate Human Cell N/A
Mouse Pcsk9-6566M Recombinant Mouse Pcsk9 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Pcsk9-6566M-B Recombinant Mouse Pcsk9 Protein Pre-coupled Magnetic Beads HEK293
Mouse Pcsk9-209M Active Recombinant Mouse Pcsk9 Protein, His-Avi-tagged, Biotinylated HEK293 His/Avi
Mouse PCSK9-812M Recombinant Mouse PCSK9 Protein (Met1-Gln694), MlgG1 Fc-tagged HEK293 MlgG1 Fc Met1-Gln694
Mouse Pcsk9-412M Recombinant Mouse Pcsk9 Protein, His-tagged HEK293 His 694
Mouse Pcsk9-803M Active Recombinant Mouse Pcsk9 protein(Met1-Gln694), His-tagged HEK293 C-His Met1-Gln694
Mouse Pcsk9-265M Recombinant Mouse PCSK9 Protein, His-tagged(C-ter) HEK293 His(C-ter) Gln35-Gln694
Mouse Pcsk9-6765M Recombinant Mouse Pcsk9 Protein (Gln35-Gln155, Ser156-Gln692), C-His tagged Mammalian cells C-His Gln35-Gln155, Ser156-Gln692
Mouse Pcsk9-020M Recombinant Mouse Pcsk9 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Rat PCSK9-1257R Acitve Recombinant Rat PCSK9 protein(Met1-Gln691), His-tagged HEK293 C-His Met1-Gln691
Rat Pcsk9-915R Active Recombinant Rat Pcsk9 protein, His-tagged HEK293 His Gln 31 - Gln 691
Rat Pcsk9-1156R Recombinant Rat Pcsk9 protein, His & GST-tagged E.coli His/GST Trp164~Phe428
Rat PCSK9-4311R Recombinant Rat PCSK9 Protein Mammalian Cell His
Rat PCSK9-2306RCL Recombinant Rat PCSK9 cell lysate Human Cell N/A
Rat PCSK9-3971R-B Recombinant Rat PCSK9 Protein Pre-coupled Magnetic Beads HEK293
Rat PCSK9-3971R Recombinant Rat PCSK9 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat PCSK9-413R Recombinant Rat PCSK9 Protein, His-tagged HEK293 His 691
Chinese hamster PCSK9-406C Recombinant Chinese hamster PCSK9 Protein, His-tagged HEK293 His 691
Cynomolgus PCSK9-358C Active Recombinant Cynomolgus PCSK9 protein, His-tagged HEK293 His Gln 31 - Gln 692
Cynomolgus monkey PCSK9-405C Recombinant Cynomolgus monkey PCSK9 Protein, His-tagged HEK293 His 692
Hamster PCSK9-313H Active Recombinant Hamster PCSK9 protein, His-tagged HEK293 His Gln 30 - Ser 691
Macaca mulatta (Rhesus macaque) PCSK9-5543M Recombinant Rhesus macaque PCSK9 Protein (Q31-Q692), C-His tagged Mammalian cells C-His Q31-Q692
Rhesus PCSK9-486R Recombinant Rhesus PCSK9 Protein (Met1-Gln692), MIgG1 Fc-tagged HEK293 MIgG1 Fc Met1-Gln692
Rhesus macaque PCSK9-311R Active Recombinant Rhesus macaque PCSK9 protein, His-tagged HEK293 His Gln 31 - Gln 692
Rhesus Macaque PCSK9-3334R Recombinant Rhesus monkey PCSK9 Protein, His-tagged Mammalian Cell His
Rhesus Macaque PCSK9-2775RCL Recombinant Rhesus PCSK9 cell lysate Human Cell N/A
Rhesus Macaque PCSK9-3152R Recombinant Rhesus Macaque PCSK9 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque PCSK9-3152R-B Recombinant Rhesus Macaque PCSK9 Protein Pre-coupled Magnetic Beads HEK293
Rhesus macaque PCSK9-414R Recombinant Rhesus macaque PCSK9 Protein, His-tagged HEK293 His 692
Kit-0665 PCSK9-BIRC2 in vitro Binding Assay Kit N/A
Kit-1806 PCSK9(D374T)-LDLR TR-FRET Assay Kit N/A
Kit-0666 PCSK9-LDLR in vitro Binding Assay Kit N/A
Kit-1807 PCSK9[Biotinylated]-LDLR Binding Assay Kit N/A
Kit-1808 PCSK9-LDLR TR-FRET Assay Kit N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

Pcsk9 involved in several pathways and played different roles in them. We selected most pathways Pcsk9 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with Pcsk9 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

Pcsk9 has several biochemical functions, for example, apolipoprotein binding, apolipoprotein receptor binding, low-density lipoprotein particle binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Pcsk9 itself. We selected most functions Pcsk9 had, and list some proteins which have the same functions with Pcsk9. You can find most of the proteins on our site.

Function Related Protein
apolipoprotein bindingPLG;LRP1;ABCA1;VLDLR;LIPC;CANX;PCSK9;LRP4;LPL
apolipoprotein receptor bindingAPOA2;APOA1;PCSK9
low-density lipoprotein particle bindingCOLEC12;PCSK9;ANKRA2;MSR1;SCARB1;LDLR;SORL1;SCARF1;CDH13
low-density lipoprotein particle receptor bindingCRP;HSP90B1;MESDC2;SYT1;APOE;MMP13;APOA5;ARRB2;APOEA
poly(A) RNA bindingSRSF4;SRSF5;PURA;MFAP1B;RBM42;WBP11;TMSB4X;RBM12B1;NSA2
protein bindingFTCD;APPL2;POU5F1;DHX15;ANG;YWHAB;CSNK1A1;RABL2A;TES
protein self-associationNKX3;PABPN1;ACHE;ZSWIM2;DYRK1A;CTSC;PCSK9;CCDC88C;ZNF496
receptor inhibitor activity
serine-type endopeptidase activityKLK1B11;PRSS59.1;PRSS57;PRSS30;PRTN3;KLK12;PCSK6;RHBDD3;PROC
sodium channel inhibitor activitySCN1B;PCSK9;NEDD4;NEDD4L;SLC14A2;CAMK2D
very-low-density lipoprotein particle bindingPCSK9;VLDLR
very-low-density lipoprotein particle receptor bindingReln;APOEB;APOEA;LRPAP1;PCSK9;APOE

Pcsk9 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Pcsk9 here. Most of them are supplied by our site. Hope this information will be useful for your research of Pcsk9.

LDLR; MMP2; ANXA2

Research Area

Related articles

Shapiro, MD; Fazio, S; et al. Targeting PCSK9 for Therapeutic Gains. CURRENT ATHEROSCLEROSIS REPORTS 17:-(2015).
Tavori, H; Giunzioni, I; et al. PCSK9 inhibition to reduce cardiovascular disease risk: recent findings from the biology of PCSK9. CURRENT OPINION IN ENDOCRINOLOGY DIABETES AND OBESITY 22:126-132(2015).
  • Q&As
  • Reviews

Q&As (6)

Ask a question
Is there a relationship between genetic mutations in the PCSK9 protein and cardiovascular disease? 12/30/2019

Yes, some studies suggest that mutations in the PCSK9 protein gene may increase the risk of cardiovascular disease. For example, some PCSK9 mutations can cause their dysfunction, resulting in hypercholesterolemia and cardiovascular disease.

How can PCSK9 protein be used for vaccine development? 12/17/2019

PCSK9 protein is combined with immune adjuvants to make a vaccine, or mutated PCSK9 protein to induce an immune response to it, inhibit PCSK9 expression in vivo, increase LDLR levels and reduce serum cholesterol levels.

What is the relationship between PCSK9 protein and obesity? 07/23/2019

This protein may have a regulatory effect on weight and obesity, and it is associated with glucose and endocannabinin homeostasis studies have linked PCSK9 to the development of obesity and diabetes.

What are the new prospects for future therapies that inhibit PCSK9 protein? 06/26/2019

Several new anti-PCSK9 drugs are already being studied and developed, including oral drugs and gene chromosome therapies, and some drugs have advanced to early stages of clinical trials, providing new options for the treatment of PCSK9 proteins.

What drugs are currently available to inhibit the PCSK9 protein? 05/08/2019

Currently on the market to inhibit PCSK9 protein drugs include alirocumab and evolocumab.

What is the relationship between PCSK9 protein and hypercholesterolemia? 01/11/2019

PCSK9 protein can degrade LDLR protein, so its overexpression will lead to a decrease in LDLR's ability to be cleared, leading to hypercholesterolemia.

Customer Reviews (3)

Write a review
Reviews
11/13/2022

    In immunological experiments, it was found that it had good antigenicity and could induce target immune responses.

    07/07/2022

      It promoted cell growth and proliferation.

      03/04/2022

        High catalytic efficiency.

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