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Recombinant Human PRKAR1A Protein, Myc/DDK-tagged, C13 and N15-labeled

Cat.No. : PRKAR1A-2253H
Product Overview : PRKAR1A MS Standard C13 and N15-labeled recombinant protein (NP_997637) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.
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  • Gene Information
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Description : cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. This gene encodes one of the regulatory subunits. This protein was found to be a tissue-specific extinguisher that down-regulates the expression of seven liver genes in hepatoma x fibroblast hybrids. Mutations in this gene cause Carney complex (CNC). This gene can fuse to the RET protooncogene by gene rearrangement and form the thyroid tumor-specific chimeric oncogene known as PTC2. A nonconventional nuclear localization sequence (NLS) has been found for this protein which suggests a role in DNA replication via the protein serving as a nuclear transport protein for the second subunit of the Replication Factor C (RFC40). Several alternatively spliced transcript variants encoding two different isoforms have been observed.
Source : HEK293
Species : Human
Tag : Myc/DDK
Molecular Mass : 43 kDa
AA Sequence : MESGSTAASEEARSLRECELYVQKH NIQALLKDSIVQLCTARPERPMAFL REYFERLEKEEAKQIQNLQKAGTRT DSREDEISPPPPNPVVKGRRRRGAI SAEVYTEEDAASYVRKVIPKDYKTM AALAKAIEKNVLFSHLDDNERSDIF DAMFSVSFIAGETVIQQGDEGDNFY VIDQGETDVYVNNEWATSVGEGGSF GELALIYGTPRAATVKAKTNVKLWG IDRDSYRRILMGSTLRKRKMYEEFL SKVSILESLDKWERLTVADALEPVQ FEDGQKIVVQGEPGDEFFIILEGSA AVLQRRSENEEFVEVGRLGPSDYFG EIALLMNRPRAATVVARGPLKCVKL DRPRFERVLGPCSDILKRNIQQYNS FVSLSVTRTRPLEQKLISEEDLAAN DILDYKDDDDKV
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 3 months from receipt of products under proper storage and handling conditions.
Storage : Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
Concentration : 50 μg/mL as determined by BCA
Storage Buffer : 100 mM glycine, 25 mM Tris-HCl, pH 7.3.
Gene Name : PRKAR1A protein kinase cAMP-dependent type I regulatory subunit alpha [ Homo sapiens (human) ]
Official Symbol : PRKAR1A
Synonyms : PRKAR1A; protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1); PRKAR1, TSE1; cAMP-dependent protein kinase type I-alpha regulatory subunit; tissue-specific extinguisher 1; protein kinase A type 1a regulatory subunit; cAMP-dependent protein kinase regulatory subunit RIalpha; cAMP-dependent protein kinase type I-alpha regulatory chain; CAR; CNC; CNC1; PKR1; TSE1; ADOHR; PPNAD1; PRKAR1; MGC17251; DKFZp779L0468;
Gene ID : 5573
mRNA Refseq : NM_212472
Protein Refseq : NP_997637
MIM : 188830
UniProt ID : P10644

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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