Recombinant Bovine PRKAR1A

• Cat.No.: PRKAR1A-610B
• Product Overview: Recombinant Bovine PRKAR1A is produced inE. coli.MW=43kDa.

Specification

• Cat. No.: PRKAR1A-610B
• Description: cAMP-dependent protein kinase type I-alpha regulatory subunit is an enzyme that in humans is encoded by the PRKAR1A gene. cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase A (PKA), which transduces the signal through phosphorylation of different target proteins. The inactive holoenzyme of PKA is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits of PKA have been identified in humans.
• Source: E. coli.
• Purity: ≥95% (SDS-PAGE).
• Formulation: Liquid. In 10mM potassium phosphate, pH 6.8, containing 150mM NaCl, 14mM 2-mercaptoethanol, 1mM EDTA and 50% glycerol.
• Storage And Stability: -80°C. Keep the glycerol stock solution of the enzyme permanently at -20°C while pipetting to avoid loss of inhibitory activity. Avoid freeze/thaw cycles.

Gene Information

• Gene Name: PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) [ Bos taurus ]
• Synonyms: PRKAR1A; protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1); cAMP-dependent protein kinase, regulatory subunit alpha 1; cAMP-dependent protein kinase type I-alpha regulatory subunit; EC 2.7.11.1
• Gene ID: 615074
• mRNA Refseq: NM_001076358
• Protein Refseq: NP_001069826
• UniProt ID: P00514
• Chromosome Location: 19
• Pathway: Apoptosis; Insulin signaling pathway
• Function: cAMP binding; cAMP-dependent protein kinase regulator activity; kinase activity; nucleotide binding; protein binding