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Recombinant Human PSMC4 Protein, Myc/DDK-tagged, C13 and N15-labeled
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| Cat.No. : | PSMC4-3297H |
| Product Overview : | PSMC4 MS Standard C13 and N15-labeled recombinant protein (NP_006494) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells. |
| Description : | The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a member of the triple-A family of ATPases that is a component of the 19S regulatory subunit and plays a role in 26S proteasome assembly. The encoded protein interacts with gankyrin, a liver oncoprotein, and may also play a role in Parkinson's disease through interactions with synphilin-1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. |
| Source : | HEK293 |
| Species : | Human |
| Tag : | Myc/DDK |
| Molecular Mass : | 47.4 kDa |
| AA Sequence : | MEEIGILVEK AQDEIPALSV SRPQTGLSFL GPEPEDLEDL YSRYKKLQQE LEFLEVQEEY IKDEQKNLKK EFLHAQEEVK RIQSIPLVIG QFLEAVDQNT AIVGSTTGSN YYVRILSTID RELLKPNASV ALHKHSNALV DVLPPEADSS IMMLTSDQKP DVMYADIGGM DIQKQEVREA VELPLTHFEL YKQIGIDPPR GVLMYGPPGC GKTMLAKAVA HHTTAAFIRV VGSEFVQKYL GEGPRMVRDV FRLAKENAPA IIFIDEIDAI ATKRFDAQTG ADREVQRILL ELLNQMDGFD QNVNVKVIMA TNRADTLDPA LLRPGRLDRK IEFPLPDRRQ KRLIFSTITS KMNLSEEVDL EDYVARPDKI SGADINSICQ ESGMLAVREN RYIVLAKDFE KAYKTVIKKD EQEHEFYKTR TRPLEQKLIS EEDLAANDIL DYKDDDDKV |
| Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : | Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : | Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : | 50 μg/mL as determined by BCA |
| Storage Buffer : | 100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
| SDS-PAGE : |
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| Gene Name : | PSMC4 proteasome 26S subunit, ATPase 4 [ Homo sapiens (human) ] |
| Official Symbol : | PSMC4 |
| Synonyms : | PSMC4; proteasome (prosome, macropain) 26S subunit, ATPase, 4; MIP224; 26S protease regulatory subunit 6B; MB67 interacting protein; MGC8570; MGC13687; MGC23214; protease 26S subunit 6; S6; Tat binding protein 7; TBP 7; TBP7; TBP-7; Tat-binding protein 7; MB67-interacting protein; proteasome 26S subunit ATPase 4; 26S proteasome AAA-ATPase subunit RPT3; |
| Gene ID : | 5704 |
| mRNA Refseq : | NM_006503 |
| Protein Refseq : | NP_006494 |
| MIM : | 602707 |
| UniProt ID : | P43686 |
◆ Recombinant Protein
| Psmc4-5186M | Recombinant Mouse Psmc4 Protein, Myc/DDK-tagged | +Inquiry |
| PSMC4-417H | Recombinant Human PSMC4 Protein, His-tagged | +Inquiry |
| PSMC4-13584M | Recombinant Mouse PSMC4 Protein | +Inquiry |
| PSMC4-4782R | Recombinant Rat PSMC4 Protein | +Inquiry |
| PSMC4-821C | Recombinant Cynomolgus PSMC4 Protein, His-tagged | +Inquiry |
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◆ Lysates
| PSMC4-2761HCL | Recombinant Human PSMC4 293 Cell Lysate | +Inquiry |
| PSMC4-2760HCL | Recombinant Human PSMC4 293 Cell Lysate | +Inquiry |
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