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Recombinant Human RET protein, His-tagged

Cat.No.: RET-291H
Product Overview: Recombinant Human RET (S904A) (658-end) fused with His tag at N-terminal was expressed in insect cells.
Description: RET or ret proto-oncogene is a member of the cadherin superfamily that encodes one of the receptor tyrosine kinases, which are cell-surface molecules that transduce signals for cell growth and differentiation. RET can undergo oncogenic activation in vivo and in vitro by cytogenetic rearrangement. Mutations in the RET gene are associated with the disorders multiple endocrine neoplasia, type IIA, multiple endocrine neoplasia, type IIB, Hirschsprung disease, and medullary thyroid carcinoma. RET signaling pathway, by regulating the development of both the nervous and lymphoid system in the gut, plays a key role in the molecular mechanisms that orchestrate intestine organogenesis.
Source: Insect cells
Species: Human
Tag : His
Form: 50mM sodium phosphate, pH 7.0, 300mM NaCl, 150mM imidazole, 0.1mM PMSF, 0.25mM DTT, 25% glycerol.
Bio-activity: 55 nmol/min/mg
Molecular Mass: 54 kDa
Purity: > 75%
Applications: Kinase Assay
Stability: 1 year at -70 centigrade from the date of shipment.
Storage: Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Concentration: 0.1μg/μl
Gene Name: RET ret proto-oncogene [ Homo sapiens ]
Official Symbol: RET
Synonyms: RET; ret proto-oncogene; Hirschsprung disease 1 , HSCR1, MEN2A, MEN2B, MTC1, multiple endocrine neoplasia and medullary thyroid carcinoma 1; proto-oncogene tyrosine-protein kinase receptor Ret; cadherin related family member 16; CDHF12; CDHR16; PTC; RET51; proto-oncogene c-Ret; receptor tyrosine kinase; RET transforming sequence; cadherin family member 12; hydroxyaryl-protein kinase; cadherin-related family member 16; ret proto-oncogene (multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease); MTC1; HSCR1; MEN2A; MEN2B; RET-ELE1;
Gene ID: 5979
mRNA Refseq: NM_020630
Protein Refseq: NP_065681
UniProt ID: P07949
Chromosome Location: 10q11.2
Pathway: Endocytosis, organism-specific biosystem; Endocytosis, conserved biosystem; Pathways in cancer, organism-specific biosystem; SIDS Susceptibility Pathways, organism-specific biosystem; Signaling events regulated by Ret tyrosine kinase, organism-specific biosystem; Thyroid cancer, organism-specific biosystem; Thyroid cancer, conserved biosystem;
Function: ATP binding; calcium ion binding; nucleotide binding; protein binding; protein tyrosine kinase activity; receptor activity; transmembrane receptor protein tyrosine kinase activity;

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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