Active Recombinant Human TBK1 Protein
Cat.No. : | TBK1-01H |
Product Overview : | Human recombinant full length TBK1 protein without tag was expressed in insect cells (baculovirus). |
- Specification
- Gene Information
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Description : | The NF-kappa-B (NFKB) complex of proteins is inhibited by I-kappa-B (IKB) proteins, which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the IKB proteins by IKB kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation and nuclear translocation of the NFKB complex. The protein encoded by this gene is similar to IKB kinases and can mediate NFKB activation in response to certain growth factors. |
Source : | Insect cell |
Species : | Human |
Bio-activity : | ATPase activity confirmed by ADP detection assay. |
Molecular Mass : | 84 kDa |
Protein length : | 1-729 |
Purity : | ≥50% estimated by SDS-PAGE |
Stability : | ≥ 1 year |
Storage : | Store at -80 centigrade. |
Storage Buffer : | 50 mM HEPES, pH 8.0, with 150 mM sodium chloride, and 10% glycerol |
Shipping : | Dry ice in continental US, may vary elsewhere. |
Gene Name : | TBK1 TANK binding kinase 1 [ Homo sapiens (human) ] |
Official Symbol : | TBK1 |
Synonyms : | TBK1; TANK binding kinase 1; NAK; T2K; IIAE8; FTDALS4; serine/threonine-protein kinase TBK1; NF-kB-activating kinase; NF-kappa-B-activating kinase; EC 2.7.11.1 |
Gene ID : | 29110 |
mRNA Refseq : | NM_013254 |
Protein Refseq : | NP_037386 |
MIM : | 604834 |
UniProt ID : | Q9UHD2 |
Products Types
◆ Recombinant Protein | ||
TBK1-657H | Recombinant Human TBK1 Protein, His-tagged | +Inquiry |
TBK1-010H | Active Recombinant Human TBK1 Protein | +Inquiry |
Tbk1-6315M | Recombinant Mouse Tbk1 Protein, Myc/DDK-tagged | +Inquiry |
TBK1-2161H | Recombinant Human TBK1 Protein, His (Fc)-Avi-tagged | +Inquiry |
TBK1-4458R | Recombinant Rhesus Macaque TBK1 Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
TBK1-1745HCL | Recombinant Human TBK1 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionTBK1 is a critical component of the cGAS-STING pathway, which senses cytosolic DNA and triggers type I interferon responses. TBK1 phosphorylates STING, initiating downstream signaling events.
TBK1 is involved in selective autophagy processes by phosphorylating autophagy receptors and initiating the clearance of damaged organelles or pathogens. This contributes to maintaining cellular homeostasis and responding to stress conditions.
TBK1 plays a dual role in inflammation, acting as both a pro-inflammatory and anti-inflammatory mediator. Dysregulation of TBK1 is implicated in autoimmune disorders and inflammatory diseases, highlighting its complex regulatory role.
TBK1 dysfunction has been associated with neurodegenerative diseases, particularly amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The precise mechanisms linking TBK1 to these diseases are areas of active research.
TBK1 plays a crucial role in the activation of the transcription factor IRF3, leading to the induction of type I interferons. This activation is triggered by the recognition of viral nucleic acids or other pathogen-associated molecular patterns.
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