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Active Recombinant Human TBK1 Protein

Cat.No. : TBK1-01H
Product Overview : Human recombinant full length TBK1 protein without tag was expressed in insect cells (baculovirus).
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  • Gene Information
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Description : The NF-kappa-B (NFKB) complex of proteins is inhibited by I-kappa-B (IKB) proteins, which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the IKB proteins by IKB kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation and nuclear translocation of the NFKB complex. The protein encoded by this gene is similar to IKB kinases and can mediate NFKB activation in response to certain growth factors.
Source : Insect cell
Species : Human
Bio-activity : ATPase activity confirmed by ADP detection assay.
Molecular Mass : 84 kDa
Protein length : 1-729
Purity : ≥50% estimated by SDS-PAGE
Stability : ≥ 1 year
Storage : Store at -80 centigrade.
Storage Buffer : 50 mM HEPES, pH 8.0, with 150 mM sodium chloride, and 10% glycerol
Shipping : Dry ice in continental US, may vary elsewhere.
Gene Name : TBK1 TANK binding kinase 1 [ Homo sapiens (human) ]
Official Symbol : TBK1
Synonyms : TBK1; TANK binding kinase 1; NAK; T2K; IIAE8; FTDALS4; serine/threonine-protein kinase TBK1; NF-kB-activating kinase; NF-kappa-B-activating kinase; EC 2.7.11.1
Gene ID : 29110
mRNA Refseq : NM_013254
Protein Refseq : NP_037386
MIM : 604834
UniProt ID : Q9UHD2

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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What is the significance of TBK1 in the cGAS-STING signaling pathway, and how does it impact immune responses to cytosolic DNA? 04/04/2022

TBK1 is a critical component of the cGAS-STING pathway, which senses cytosolic DNA and triggers type I interferon responses. TBK1 phosphorylates STING, initiating downstream signaling events.

How does TBK1 participate in autophagy, and what are the implications for cellular homeostasis? 10/15/2021

TBK1 is involved in selective autophagy processes by phosphorylating autophagy receptors and initiating the clearance of damaged organelles or pathogens. This contributes to maintaining cellular homeostasis and responding to stress conditions.

What is the impact of TBK1 on the regulation of inflammation, and how does this influence autoimmune disorders and inflammatory diseases? 12/31/2020

TBK1 plays a dual role in inflammation, acting as both a pro-inflammatory and anti-inflammatory mediator. Dysregulation of TBK1 is implicated in autoimmune disorders and inflammatory diseases, highlighting its complex regulatory role.

Can you discuss the role of TBK1 in neurodegenerative diseases, and how dysregulation may contribute to pathogenesis? 11/23/2019

TBK1 dysfunction has been associated with neurodegenerative diseases, particularly amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The precise mechanisms linking TBK1 to these diseases are areas of active research.

Can you elaborate on the molecular mechanisms through which TBK1 regulates type I interferon production? 04/20/2018

TBK1 plays a crucial role in the activation of the transcription factor IRF3, leading to the induction of type I interferons. This activation is triggered by the recognition of viral nucleic acids or other pathogen-associated molecular patterns.

Customer Reviews (3)

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Reviews
01/03/2022

    Impressed with the quality and swift delivery.

    07/27/2020

      Five stars for this amazing lab product!

      02/20/2019

        Top-quality product, superb customer service!

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