Recombinant Human TIGIT Protein, His\Avi-tagged
Cat.No. : | TIGIT-184H |
Product Overview : | Biotinylated Recombinant Human T cell Immunoreceptor with Ig and ITIM domains is produced by our Mammalian expression system and the target gene encoding Met22-Pro141 is expressed with a 6His, Avi tag at the C-terminus. |
- Specification
- Gene Information
- Related Products
Description : | T cell immunoreceptor with Ig and ITIM domains (TIGIT) is a member of the CD28 family within the Ig superfamily of proteins. TIGIT is expressed on NK cells and subsets of activated, memory and regulatory T cells, and particularly on follicular helper T cells within secondary lymphoid organs. It binds to CD155 and Nectin-2 that appear on dendritic cells (DC) and endothelium. Ligation of TIGIT on T cells down-regulates TCR-mediated activation and subsequent proliferation, while NK cell TIGIT ligation blocks NK cell cytotoxicity. Through CD155 and Nectin-2, which also interact with DNAM-1/CD226 and CD96/Tactile, TIGIT is part of an interacting network of Ig superfamily members that may augment or oppose each other. In particular, TIGIT binding to CD155 can antagonize the effects of DNAM1. |
Source : | Human Cells |
Species : | Human |
Tag : | His\Avi |
Form : | Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. |
AA Sequence : | Met22-Pro141 |
Endotoxin : | Less than 0.1 ng/ug (1 EU/ug). |
Shipping : | Ambient |
Gene Name : | TIGIT T cell immunoreceptor with Ig and ITIM domains [ Homo sapiens (human) ] |
Official Symbol : | TIGIT |
Synonyms : | T-cell immunoreceptor with Ig and ITIM domains; VSIG9; VSTM3; TIGIT; V-set and transmembrane domain-containing protein 3; V-set and immunoglobulin domain-containing protein 9; WUCAM |
Gene ID : | 201633 |
mRNA Refseq : | NM_173799.4 |
Protein Refseq : | NP_776160.2 |
MIM : | 612859 |
UniProt ID : | Q495A1 |
Products Types
◆ Recombinant Protein | ||
TIGIT-1031H | Recombinant Human TIGIT Protein, DDK/His-tagged | +Inquiry |
Tigit-730M | Recombinant Mouse Tigit Protein | +Inquiry |
TIGIT-726C | Recombinant Cynomolgus monkey TIGIT Protein, Fc-tagged | +Inquiry |
TIGIT-163H | Recombinant Human TIGIT Protein | +Inquiry |
TIGIT-1037H | Recombinant Human TIGIT Protein, MYC/DDK-tagged | +Inquiry |
◆ Lysates | ||
TIGIT-1420MCL | Recombinant Mouse TIGIT cell lysate | +Inquiry |
TIGIT-2610HCL | Recombinant Human TIGIT cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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