TIGIT Protein

TIGIT

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TIGIT

Official Full Name T cell immunoreceptor with Ig and ITIM domains
Background This gene encodes a member of the PVR (poliovirus receptor) family of immunoglobin proteins. The product of this gene is expressed on several classes of T cells including follicular B helper T cells (TFH). The protein has been shown to bind PVR with high affinity; this binding is thought to assist interactions between TFH and dendritic cells to regulate T cell dependent B cell responses.
Synonyms TIGIT; T cell immunoreceptor with Ig and ITIM domains; V set and immunoglobulin domain containing 9 , V set and transmembrane domain containing 3 , VSIG9, VSTM3; T-cell immunoreceptor with Ig and ITIM domains; DKFZp667A205; FLJ39873; V-set and transmembrane domain containing 3; V-set and immunoglobulin domain containing 9; Washington University cell adhesion molecule; V-set and transmembrane domain-containing protein 3; V-set and immunoglobulin domain-containing protein 9; VSIG9; VSTM3; WUCAM
    • Species :
    • Cynomolgus
    • Cynomolgus Monkey
    • Cynomolgus/Rhesus macaque
    • Human
    • Mouse
    • Mus musculus (Mouse)
    • Rabbit
    • Rat
    • Source :
    • CHO
    • E.coli
    • E.coli expression system
    • HEK293
    • HEK293T
    • Human Cell
    • Human cells
    • Mammalian cells
    • Tag :
    • Avi
    • Fc
    • C-6His-Avi
    • DDK
    • His
    • DYKDDDDK
    • Fc Chimera
    • GST
    • hFc
    • HIgG1 Fc
    • His(C-ter)
    • His\Avi
    • T7
    • His-Avi
    • His-SUMO
    • HlgG1 Fc
    • human
    • IgG1
    • Mouse
    • IgG2a
    • MYC/DDK
    • Myc
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human TIGIT-103H Active Recombinant Human TIGIT Protein, Fc-tagged CHO Fc
    Human TIGIT-104H Active Recombinant Human TIGIT Protein, His-tagged CHO His
    Human TIGIT-105H Active Recombinant Human TIGIT, Fc-tagged CHO Fc
    Human TIGIT-356H Active Recombinant Human TIGIT, Fc Chimera CHO Fc Chimera
    Human TIGIT-360H Active Recombinant Human TIGIT protein, His & Avi-tagged, Biotinylated HEK293 His/Avi
    Mouse Tigit-108M Active Recombinant Mouse Tigit, Fc-tagged Human Cell Fc
    Mouse Tigit-693M Active Recombinant Mouse Tigit, Fc Chimera Mammalian cells Fc Chimera
    Cynomolgus Monkey TIGIT-197C Active Recombinant Cynomolgus Monkey TIGIT protein, Fc-tagged HEK293 Fc
    Human TIGIT-2347HB Active Recombinant Human TIGIT protein, His-tagged, Biotinylated HEK293 His
    Cynomolgus TIGIT-119C Active Recombinant Cynomolgus TIGIT protein (Met1-Pro209), hFc-tagged HEK293 hFc
    Human TIGIT-0631H Recombinant Human TIGIT protein, Fc & Avi-tagged, Biotinylated HEK293 Avi/Fc
    Human TIGIT-106H Recombinant Human TIGIT protein, His-tagged HEK293 His
    Human TIGIT-107H Recombinant Human TIGIT protein, Fc-tagged HEK293 human/IgG1/Fc
    Human TIGIT-108H Recombinant Human TIGIT protein, Mouse IgG2a Fc-tagged, low endotoxin HEK293 Mouse/IgG2a/Fc
    Human TIGIT-135H Recombinant Human TIGIT protein, T7/His-tagged E.coli T7/His
    Human TIGIT-2347H Recombinant Human TIGIT, His tagged Human Cell His
    Human TIGIT-3232H Recombinant Human TIGIT, GST-tagged E.coli GST
    Mouse Tigit-109M Recombinant Mouse Tigit protein, His-tagged HEK293 His
    Mouse Tigit-110M Recombinant Mouse Tigit protein, Fc-tagged HEK293 human/IgG1/Fc
    Mouse Tigit-2348M Recombinant Mouse Tigit, His tagged Human Cell His
    Rat TIGIT-205R Recombinant Rat TIGIT protein, Fc-tagged HEK293 human/IgG1/Fc
    Rabbit TIGIT-260R Recombinant Rabbit TIGIT protein, Fc-tagged HEK293 human/IgG1/Fc
    Cynomolgus/Rhesus macaque TIGIT-120C Recombinant Cynomolgus/Rhesus macaque TIGIT protein, Fc-tagged HEK293 human/IgG1/Fc
    Cynomolgus/Rhesus macaque TIGIT-121C Recombinant Cynomolgus/Rhesus macaque TIGIT protein, His-tagged (HPLC-verified) HEK293 His
    Human TIGIT-2610HCL Recombinant Human TIGIT cell lysate Human Cell N/A
    Mouse TIGIT-1420MCL Recombinant Mouse TIGIT cell lysate Human Cell N/A
    Mus musculus (Mouse) RFL31627MF Recombinant Full Length Mouse T-Cell Immunoreceptor With Ig And Itim Domains(Tigit) Protein, His-Tagged E.coli expression system His
    Human TIGIT-106HAF488 Recombinant Human TIGIT Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 His
    Human TIGIT-106HAF555 Recombinant Human TIGIT Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 His
    Human TIGIT-106HAF647 Recombinant Human TIGIT Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 His
    Human TIGIT-106HF Recombinant Human TIGIT Protein, His-tagged, FITC conjugated HEK293 His
    Human TIGIT-12H Recombinant Human TIGIT Protein, C-6His-Avi tagged, Biotinylated Human Cell C-6His-Avi
    Human TIGIT-151H Recombinant Human TIGIT Protein, DYKDDDDK-tagged Human cells DYKDDDDK
    Human TIGIT-184H Recombinant Human TIGIT Protein, His\Avi-tagged Human Cell His\Avi
    Mouse Tigit-2348MAF488 Recombinant Mouse Tigit Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 His
    Mouse Tigit-2348MAF555 Recombinant Mouse Tigit Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 His
    Mouse Tigit-2348MAF647 Recombinant Mouse Tigit Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 His
    Mouse Tigit-2348MF Recombinant Mouse Tigit Protein, His-tagged, FITC conjugated HEK293 His
    Human TIGIT-23H Recombinant Human TIGIT Protein E.coli
    Human TIGIT-306H Recombinant Human TIGIT Protein (ECD), His-tagged(C-ter) HEK293 His(C-ter)
    Human TIGIT-4486H Recombinant Human TIGIT protein, His-SUMO-tagged E.coli His-SUMO
    Mouse Tigit-7407MAF488 Recombinant Mouse Tigit Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Fc
    Mouse Tigit-7407MAF555 Recombinant Mouse Tigit Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Fc
    Mouse Tigit-7407MAF647 Recombinant Mouse Tigit Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Fc
    Mouse Tigit-7407MF Recombinant Mouse Tigit Protein, Fc-tagged, FITC conjugated HEK293 Fc
    Human TIGIT-1031H Recombinant Human TIGIT Protein, DDK/His-tagged HEK293 DDK/His
    Human TIGIT-1037H Recombinant Human TIGIT Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human TIGIT-163H Recombinant Human TIGIT Protein E.coli N/A
    Human TIGIT-3357H Recombinant Human TIGIT Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human TIGIT-434HG GMP Recombinant Human TIGIT protein, Fc-tagged HEK293 Fc
    Human TIGIT-454H Recombinant Human TIGIT Protein (Met1-Pro141), HIgG1 Fc-tagged, Biotinylated HEK293 HIgG1 Fc
    Human TIGIT-495H Recombinant Human TIGIT protein, His-Avi-tagged HEK293 His-Avi
    Mouse Tigit-016M Recombinant Mouse Tigit Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Mouse Tigit-1440M Recombinant Mouse Tigit protein, His & T7-tagged E.coli His/T7
    Rat Tigit-1441R Recombinant Rat Tigit protein, His & T7-tagged E.coli His/T7
    Cynomolgus TIGIT-1144C Recombinant Cynomolgus TIGIT Protein (Met1-Pro209), HlgG1 Fc-tagged HEK293 HlgG1 Fc
    Cynomolgus/Rhesus macaque TIGIT-365C Recombinant Cynomolgus/Rhesus macaque TIGIT protein, His-tagged (HPLC-verified) HEK293 His

    TIGIT involved in several pathways and played different roles in them. We selected most pathways TIGIT participated on our site, such as Cell adhesion molecules (CAMs), which may be useful for your reference. Also, other proteins which involved in the same pathway with TIGIT were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cell adhesion molecules (CAMs) NLGN2A; GLYCAM1; ICAM1; NRXN3; CLDN14; NRXN2; CD6; HLA-DQA1; CLDNJ; CLDN1

    TIGIT has several biochemical functions, for example, cell adhesion molecule binding, protein binding, protein homodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TIGIT itself. We selected most functions TIGIT had, and list some proteins which have the same functions with TIGIT. You can find most of the proteins on our site.

    Function Related Protein
    cell adhesion molecule binding ITGAL; PVRL4; LPHN1; PTBP3; NRXN1; CD200; CD1d1; CADM2A; CADM1; SELL
    protein binding CCR3; RAB8B; TRIM3; KRT5; SBDS; ANAPC4; H2-AB1; HER11; ZNF18; SUN1
    protein homodimerization activity DMRTC1C2; SFTPC; ABCB9; TERF2; TREX2; GALE; RAP1GAP; DST; LRP6; ACCS
    receptor activity TNFRSF17; LRP2; SMAGP; CD244; PLXNA1; THRAP3; NOTCH4; NOTCH1A; BTLA; RAMP1
    receptor binding GNB2L1; SRMS; MSTN; ACOX3; WNT4A; ADCYAP1; PTK6; CCL17; CCL2; IAPP

    TIGIT has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TIGIT here. Most of them are supplied by our site. Hope this information will be useful for your research of TIGIT.

    CD226; PVR; PVRL2; PVRL4; PVRL3

    Johnston, RJ; Comps-Agrar, L; et al. The Immunoreceptor TIGIT Regulates Antitumor and Antiviral CD8(+) T Cell Effector Function. CANCER CELL 26:923-937(2014).
    Zhang, T; Wang, JH; et al. Increased Expression of TIGIT on CD4(+) T Cells Ameliorates Immune-Mediated Bone Marrow Failure of Aplastic Anemia. JOURNAL OF CELLULAR BIOCHEMISTRY 115:1918-1927(2014).

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