|Official Full Name||T cell immunoreceptor with Ig and ITIM domains|
|Background||This gene encodes a member of the PVR (poliovirus receptor) family of immunoglobin proteins. The product of this gene is expressed on several classes of T cells including follicular B helper T cells (TFH). The protein has been shown to bind PVR with high affinity; this binding is thought to assist interactions between TFH and dendritic cells to regulate T cell dependent B cell responses.|
|Synonyms||TIGIT; T cell immunoreceptor with Ig and ITIM domains; V set and immunoglobulin domain containing 9 , V set and transmembrane domain containing 3 , VSIG9, VSTM3; T-cell immunoreceptor with Ig and ITIM domains; DKFZp667A205; FLJ39873; V-set and transmembrane domain containing 3; V-set and immunoglobulin domain containing 9; Washington University cell adhesion molecule; V-set and transmembrane domain-containing protein 3; V-set and immunoglobulin domain-containing protein 9; VSIG9; VSTM3; WUCAM|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
TIGIT involved in several pathways and played different roles in them. We selected most pathways TIGIT participated on our site, such as Cell adhesion molecules (CAMs), which may be useful for your reference. Also, other proteins which involved in the same pathway with TIGIT were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Cell adhesion molecules (CAMs)||NLGN2A; GLYCAM1; ICAM1; NRXN3; CLDN14; NRXN2; CD6; HLA-DQA1; CLDNJ; CLDN1|
TIGIT has several biochemical functions, for example, cell adhesion molecule binding, protein binding, protein homodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TIGIT itself. We selected most functions TIGIT had, and list some proteins which have the same functions with TIGIT. You can find most of the proteins on our site.
|cell adhesion molecule binding||ITGAL; PVRL4; LPHN1; PTBP3; NRXN1; CD200; CD1d1; CADM2A; CADM1; SELL|
|protein binding||CCR3; RAB8B; TRIM3; KRT5; SBDS; ANAPC4; H2-AB1; HER11; ZNF18; SUN1|
|protein homodimerization activity||DMRTC1C2; SFTPC; ABCB9; TERF2; TREX2; GALE; RAP1GAP; DST; LRP6; ACCS|
|receptor activity||TNFRSF17; LRP2; SMAGP; CD244; PLXNA1; THRAP3; NOTCH4; NOTCH1A; BTLA; RAMP1|
|receptor binding||GNB2L1; SRMS; MSTN; ACOX3; WNT4A; ADCYAP1; PTK6; CCL17; CCL2; IAPP|
TIGIT has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TIGIT here. Most of them are supplied by our site. Hope this information will be useful for your research of TIGIT.
CD226; PVR; PVRL2; PVRL4; PVRL3