| Description : |
This gene encodes a protein that belongs to the ubiquitin-specific processing protease family of proteins. The encoded protein is thought to regulate the morphology of the endosome by ubiquitination of proteins on this organelle and is involved in cargo sorting and membrane trafficking at the early endosome stage. This protein is required for the cell to enter the S phase of the cell cycle and also functions as a positive regulator in the Hedgehog signaling pathway in development. Pseudogenes of this gene are present on chromosomes 2 and 6. Alternate splicing results in multiple transcript variants. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
127.3 kDa |
| AA Sequence : |
MPAVASVPKELYLSSSLKDLNKKTE VKPEKISTKSYVHSALKIFKTAEEC RLDRDEERAYVLYMKYVTVYNLIKK RPDFKQQQDYFHSILGPGNIKKAVE EAERLSESLKLRYEEAEVRKKLEEK DRQEEAQRLQQKRQETGREDGGTLA KGSLENVLDSKDKTQKSNGEKNEKC ETKEKGAITAKELYTMMTDKNISLI IMDARRMQDYQDSCILHSLSVPEEA ISPGVTASWIEAHLPDDSKDTWKKR GNVEYVVLLDWFSSAKDLQIGTTLR SLKDALFKWESKTVLRNEPLVLEGG YENWLLCYPQYTTNAKVTPPPRRQN EEVSISLDFTYPSLEESIPSKPAAQ TPPASIEVDENIELISGQNERMGPL NISTPVEPVAASKSDVSPIIQPVPS IKNVPQIDRTKKPAVKLPEEHRIKS ESTNHEQQSPQSGKVIPDRSTKPVV FSPTLMLTDEEKARIHAETALLMEK NKQEKELRERQQEEQKEKLRKEEQE QKAKKKQEAEENEITEKQQKAKEEM EKKESEQAKKEDKETSAKRGKEITG VKRQSKSEHETSDAKKSVEDRGKRC PTPEIQKKSTGDVPHTSVTGDSGSG KPFKIKGQPESGILRTGTFREDTDD TERNKAQREPLTRARSEEMGRIVPG LPSGWAKFLDPITGTFRYYHSPTNT VHMYPPEMAPSSAPPSTPPTHKAKP QIPAERDREPSKLKRSYSSPDITQA IQEEEKRKPTVTPTVNRENKPTCYP KAEISRLSASQIRNLNPVFGGSGPA LTGLRNLGNTCYMNSILQCLCNAPH LADYFNRNCYQDDINRSNLLGHKGE VAEEFGIIMKALWTGQYRYISPKDF KITIGKINDQFAGYSQQDSQELLLF LMDGLHEDLNKADNRKRYKEENNDH LDDFKAAEHAWQKHKQLNESIIVAL FQGQFKSTVQCLTCHKKSRTFEAFM YLSLPLASTSKCTLQDCLRLFSKEE KLTDNNRFYCSHCRARRDSLKKIEI WKLPPVLLVHLKRFSYDGRWKQKLQ TSVDFPLENLDLSQYVIGPKNNLKK YNLFSVSNHYGGLDGGHYTAYCKNA ARQRWFKFDDHEVSDISVSSVKSSA AYILFYTSLGPRVTDVATTRTRPLE QKLISEEDLAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
