USP8

  • Official Full Name

    ubiquitin specific peptidase 8

  • Overview

    Ubiquitinating enzymes (UBEs) catalyze protein ubiquitination, a reversible process countered by deubiquitinating enzyme (DUB) action. Five DUB subfamilies are recognized, including the USP, UCH, OTU, MJD and JAMM enzymes. The deubiquitinating enzyme, ubi
  • Synonyms

    USP8; ubiquitin specific peptidase 8; ubiquitin specific protease 8; ubiquitin carboxyl-terminal hydrolase 8; HumORF8; KIAA0055; UBPY; hUBPy; ubiquitin isopeptidase Y; ubiquitin thioesterase 8; deubiquitinating enzyme 8; ubiquitin thiolesterase 8; ubiquit;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rhesus Macaque
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Sf9 Insect Cell
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His|SUMO
  • Myc
  • DDK
  • N/A
  • No tag
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • USP8 Related Research Area

USP8 involved in several pathways and played different roles in them. We selected most pathways USP8 participated on our site, such as Endocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with USP8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
EndocytosisDNM1B;RAB7A;BF1;TGFB1;IL2RGA;CYTH4B;ARRB1;WIPF1;SH3GLB1

USP8 has several biochemical functions, for example, SH3 domain binding, cysteine-type endopeptidase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by USP8 itself. We selected most functions USP8 had, and list some proteins which have the same functions with USP8. You can find most of the proteins on our site.

Function Related Protein
SH3 domain bindingSIRPA;CASP9;ADAM15;ELMO1;SH3BP5;ARHGAP6;LYN;ILK;ZFP106
cysteine-type endopeptidase activityUSP16;USP15;CASP14;USP43A;CASP7;CTS7;USP12A;USP8;CTSSB.1
protein bindingPPIF;CCNF;ZNF224;MARCKSL1;GORASP1;MID2;HCST;PPP1R2P9;DUT
ubiquitin-specific protease activityATXN3;YOD1;USP18;USP6;USP50;OTUD6A;OTUD1;OTUB1;MYSM1

USP8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with USP8 here. Most of them are supplied by our site. Hope this information will be useful for your research of USP8.

YWHAZ; CHMP1B; YWHAB; Grap2; CHMP1A; CHMP4C

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