Recombinant Mouse Gpnmb Protein, Myc/DDK-tagged

• Cat.No.: Gpnmb-3290M
• Product Overview: Purified recombinant protein of mouse full-length glycoprotein (transmembrane) nmb (Gpnmb), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Could be a melanogenic enzyme.
• Source: HEK293T
• Species: Mouse
• Tag: Myc/DDK
• Molecular Mass: 63.7 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Gpnmb glycoprotein (transmembrane) nmb [ Mus musculus (house mouse) ]
• Official Symbol: Gpnmb
• Synonyms: GPNMB; glycoprotein (transmembrane) nmb; transmembrane glycoprotein NMB; osteoactivin; iris pigment dispersion; dendritic cell-associated transmembrane protein; dendritic cell-associated heparin sulfate proteoglycan-dependent integrin ligand; ipd; Dchil; DC-HIL
• Gene ID: 93695
• mRNA Refseq: NM_053110
• Protein Refseq: NP_444340
• UniProt ID: Q99P91

Reviews

06/29/2022

The potency and power of this protein met my expectations.

02/01/2022

There are no adverse reactions and few side effects.

08/08/2021

The quality of this one is very good, and they also have a long lifespan, and I am very satisfied with this product.

Q&As

How to prepare GPNMB recombinant protein in the experiment?

In the experiment, the GPNMB gene can be introduced into the expression vector by gene cloning technology, and then the GPNMB recombinant protein can be expressed in Escherichia coli or eukaryotic cells.

How to use animal models to study the function and disease mechanism of GPNMB recombinant protein?

Animal models carrying human mutant genes can be constructed using transgenic or gene editing technology to study the role and disease mechanism of GPNMB recombinant protein in vivo. These animal models can be used to study the effects of GPNMB recombinant proteins on tumor growth, metastasis, and drug resistance.

What are the treatments for GPNMB recombinant protein?

The current treatments for GPNMB recombinant protein mainly include gene therapy, protein replacement therapy, and drug therapy for cell surface receptors and signal transduction processes.

What is the significance of GPNMB recombinant protein in tumor diagnosis and treatment?

By detecting the expression level and modification status of GPNMB recombinant protein, it can be used to diagnose certain tumor diseases. In addition, the recombinant protein of GPNMB may also become a new target for the treatment of tumors, providing new ideas and methods for tumor treatment.

How does GPNMB recombinant protein interact with other proteins?

GPNMB recombinant protein can interact with other proteins, such as cell surface receptors such as integrin, and participate in cell signal transduction processes.

If the level of GPNMB recombinant protein is abnormal, what should be treated?

If the level of GPNMB recombinant protein is abnormal, the treatment may include the use of drugs or other special treatments, depending on the condition and the doctor's recommendation.