GPNMB Protein

GPNMB

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GPNMB

Official Full Name glycoprotein (transmembrane) nmb
Background Transmembrane glycoprotein NMB is a protein that in humans is encoded by the GPNMB gene. The mouse and rat orthologues of GPNMB are known as DC-HIL and Osteoactivin (OA), respectively. Two transcript variants encoding 560 and 572 amino acid isoforms have been characterized for this gene in humans. GPNMB is a type I transmembrane glycoprotein which shows homology to the pmel17 precursor, a melanocyte-specific protein. GPNMB has been reported to be expressed in various cell types, including: melanocytes, osteoclasts, osteoblasts, dendritic cells, and it is overexpressed in various cancer types. In melanocytic cells and osteoclasts the GPNMB gene is transcritionally regulated by Microphthalmia-associated transcription factor. In osteoblast progenitor cells, Osteoactivin works as a positive regulator of osteoblast differentiation during later stages of matrix maturation and mineralization that is mediated at least in part by BMP-2 in a SMAD1 dependent manner to promote osteoblast differentiation. In addition, using a rat fracture model, Osteoactivin (OA) enhances the repairing process in bone fracture, demonstrated by its high expression during chondrogenesis (soft callus) and osteogenesis (hard callus) compared to the intact femurs that is why Osteoactivin (OA) could be a novel therapeutic agent used to treat generalized osteoporosis or localized osteopenia during fracture repair by stimulating bone growth and regeneration. Similarly, Osteoactivin expression increases during osteoclast differentiation and it is functionally implicated in this process, possibly by promoting the fusion of osteoclast progenitor cells.
Synonyms GPNMB; HGFIN; NMB; glycoprotein (transmembrane) nmb; dendritic cell-associated heparin sulfate proteoglycan-dependent integrin ligand; dendritic cell-associated transmembrane protein; iris pigment dispersion; osteoactivin; transmembrane glycoprotein NMB;
    • Species :
    • Human
    • Mouse
    • Rhesus Macaque
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Human Cell
    • Human cells
    • In Vitro Cell Free System
    • Insect Cell
    • Mammalian Cell
    • Mammalian cells
    • Wheat Germ
    • Tag :
    • DYKDDDDK
    • Fc
    • Fc Chimera
    • Flag
    • GST
    • hFc
    • hFc&His
    • His
    • His (Fc)-Avi
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human GPNMB-747H Active Recombinant Human GPNMB, Fc Chimera Mammalian cells Fc Chimera Inquiry
    Human GPNMB-747HAF488 Active Recombinant Human GPNMB Protein, Fc-tagged, Alexa Fluor 488 conjugated Mammalian cells Fc
    Human GPNMB-747HAF555 Active Recombinant Human GPNMB Protein, Fc-tagged, Alexa Fluor 555 conjugated Mammalian cells Fc
    Human GPNMB-747HAF647 Active Recombinant Human GPNMB Protein, Fc-tagged, Alexa Fluor 647 conjugated Mammalian cells Fc
    Human GPNMB-747HF Active Recombinant Human GPNMB Protein, Fc-tagged, FITC conjugated Mammalian cells Fc
    Human GPNMB-13430H Recombinant Human GPNMB, GST-tagged E.coli GST Inquiry
    Human GPNMB-2280H Recombinant Human GPNMB, His-tagged E.coli His Inquiry
    Human GPNMB-3782H Recombinant Human GPNMB, His tagged Human Cell His Inquiry
    Human GPNMB-3783H Recombinant Human GPNMB protein, His-tagged HEK293 His Inquiry
    Human GPNMB-555H Recombinant Human GPNMB, Fc tagged Human Cell His Inquiry
    Mouse GPNMB-872M Recombinant Mouse GPNMB Protein, His-tagged HEK293 His Inquiry
    Rhesus Macaque GPNMB-1939R Recombinant Rhesus monkey GPNMB Protein, His-tagged Mammalian Cell His Inquiry
    Human GPNMB-1886HCL Recombinant Human GPNMB cell lysate Human Cell N/A Inquiry
    Mouse GPNMB-1423MCL Recombinant Mouse GPNMB cell lysate Human Cell N/A Inquiry
    Human GPNMB-01H Recombinant Human GPNMB Protein, His-Tagged Insect Cell His Inquiry
    Human GPNMB-1013H Recombinant Human GPNMB Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi Inquiry
    Human GPNMB-1265H Recombinant Human GPNMB protein, hFc&His-tagged HEK293 hFc&His Inquiry
    Human GPNMB-151H Recombinant Human GPNMB Protein, DYKDDDDK-tagged Human cells DYKDDDDK Inquiry
    Rhesus Macaque GPNMB-1759R Recombinant Rhesus Macaque GPNMB Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi Inquiry
    Human GPNMB-190H Recombinant Human GPNMB Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi Inquiry
    Human GPNMB-2980H Recombinant Human GPNMB protein, His-tagged E.coli His Inquiry
    Human GPNMB-321HFL Recombinant Full Length Human GPNMB Protein, C-Flag-tagged Mammalian cells Flag Inquiry
    Human GPNMB-402H Recombinant Human GPNMB Protein, His-tagged HEK293 His Inquiry
    Human GPNMB-5557HF Recombinant Full Length Human GPNMB Protein, GST-tagged In Vitro Cell Free System GST Inquiry
    Human GPNMB-748H Recombinant Human GPNMB Protein, hFc-tagged HEK293 hFc Inquiry
    Human GPNMB-82H Recombinant Human GPNMB Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi Inquiry
    Human GPNMB-83H Recombinant Human GPNMB Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi Inquiry
    Human GPNMB-84H Recombinant Human GPNMB Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi Inquiry
    Human GPNMB-85H Recombinant Human GPNMB Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi Inquiry
    Human GPNMB-86H Recombinant Human GPNMB Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi Inquiry
    Human GPNMB-87H Recombinant Human GPNMB Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi Inquiry
    Human GPNMB-1579H Recombinant Human GPNMB Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK Inquiry
    Human GPNMB-2238H Recombinant Human GPNMB Protein, MYC/DDK-tagged HEK293 Myc/DDK Inquiry
    Human GPNMB-5162H Recombinant Human GPNMB Protein, GST-tagged Wheat Germ GST Inquiry
    Human GPNMB-747HA Recombinant Human GPNMB protein, Fc-tagged, APC labeled Mammalian cells Fc Inquiry
    Human GPNMB-747HP Recombinant Human GPNMB protein, Fc-tagged, R-PE labeled Mammalian cells Fc Inquiry
    Mouse Gpnmb-3290M Recombinant Mouse Gpnmb Protein, Myc/DDK-tagged HEK293T Myc/DDK Inquiry

    GPNMB involved in several pathways and played different roles in them. We selected most pathways GPNMB participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with GPNMB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein

    GPNMB has several biochemical functions, for example, heparin binding, integrin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GPNMB itself. We selected most functions GPNMB had, and list some proteins which have the same functions with GPNMB. You can find most of the proteins on our site.

    Function Related Protein
    heparin binding SELL; SERPINC1; WISP1; Itgam&Itgb2; PRELP; HDGF; LTBP2; COL20A1; KAL1; ABI3BP
    integrin binding FBN1; COL4A3; Tcam1; Npnt; COL3A1; NIPAL1; TGFBI; DMP1; ITGB1BP2; FN1A

    GPNMB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GPNMB here. Most of them are supplied by our site. Hope this information will be useful for your research of GPNMB.

    SMAD4

    Torres, C; Linares, A; et al. The Potential Role of the Glycoprotein Osteoactivin/Glycoprotein Nonmetastatic Melanoma Protein B in Pancreatic Cancer. PANCREAS 44:302-310(2015).

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