Active Recombinant Mouse Il7 Protein

• Cat.No.: Il7-117M
• Product Overview: Purified recombinant protein of Mouse interleukin 7 (Il7) without tag was expressed in E.coli.

Specification

• Description: The protein encoded by this gene is a hematopoietic growth factor important for B and T cell development. Alternative splicing results in several transcript variants encoding different isoforms.
• Source: E. coli
• Species: Mouse
• Bio-activity: The ED50 as determined by the dose-dependent stimulation of the proliferation of murine 2E8 cells is< 0.2 ng/ml, corresponding to a specific activity of≥ 5 x 10^6 units/mg.
• Molecular Mass: 15 kDa
• AA Sequence: MECHIKDKEGKAYESVLMISIDELD KMTGTDSNCPNNEPNFFRKHVCDDT KEAAFLNRAARKLKQFLKMNISEEF NVHLLTVSQGTQTLVNCTSKEEKNV KEQKKNDACFLKRLLREIKTCWNKI LKGSI
• Endotoxin: Endotoxin level is < 0.1 ng/µg of protein (< 1 EU/µg)
• Purity: >95%, as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for at least 6 months from date of receipt under proper storage and handling conditions.
• Storage: Store at -80 centigrade.
• Storage Buffer: Lyophilized from a 0.2 µM filtered solution of 20mM phosphate buffer,100mM NaCl, pH 7.2
• Reconstitution: Resuspend the protein in the desired concentration in proper buffer.

Gene Information

• Gene Name: Il7 interleukin 7 [ Mus musculus (house mouse) ]
• Official Symbol: Il7
• Synonyms: Il7; interleukin 7; Il-7; hlb368; A630026I06Rik; interleukin-7
• Gene ID: 16196
• mRNA Refseq: NM_008371
• Protein Refseq: NP_032397
• UniProt ID: P10168

Reviews

03/27/2022

Effective in signal transduction pathway.

04/17/2021

IL7 has good absorbability and high bioavailability.

11/27/2020

Good stability under different environmental conditions

Q&As

What are the application scenarios of IL7?

IL7 is widely used in the research and development of immunotherapy protocols, can enhance the body's immune function, for the treatment of cancer, infection, autoimmune diseases and other diseases.

What is the mechanism of IL7 in the treatment of bladder cancer?

IL7 can activate the body's immune system and enhance the immune cells' attack on bladder cancer.

What is the optimal dose of IL7 in the treatment of leukemia?

The dosage of IL7 in the treatment of leukemia needs to be calculated individually according to the specific situation of the patient.

Does the efficacy of IL7 in the treatment of infectious diseases?

It can enhance the function of the body's immune system, and has a certain effect on some infectious diseases.

Are there have any efficacy of IL7 in the treatment of specific cancers?

Recombinant IL7 protein may have some therapeutic effect on specific cancers by activating T cells, but further clinical studies are needed.

How to prepare IL7?

This is obtained by recombinant DNA technology, inserting foreign genes into the host expression system, and then through purification and other steps.