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Recombinant Mouse Wdr61 Protein, Myc/DDK-tagged
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Cat.No. : | Wdr61-6986M |
Product Overview : | Purified recombinant protein of Mouse WD repeat domain 61 (Wdr61), with C-terminal MYC/DDK tag, expressed in HEK293T cells. |
Description : | Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. Required for mono- and trimethylation on histone H3 'Lys-4' (H3K4me3), dimethylation on histone H3 'Lys-79' (H3K4me3). Required for Hox gene transcription. Component of the SKI complex which is thought to be involved in exosome-mediated RNA decay and associates with transcriptionally active genes in a manner dependent on PAF1C. |
Source : | HEK293T |
Species : | Mouse |
Tag : | Myc/DDK |
Molecular Mass : | 33.8 kDa |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Storage : | Store at -80 centigrade after receiving vials. |
Concentration : | >50 μg/mL as determined by microplate BCA method |
Storage Buffer : | 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Gene Name : | Wdr61 WD repeat domain 61 [ Mus musculus (house mouse) ] |
Official Symbol : | Wdr61 |
Synonyms : | WDR61; WD repeat domain 61; WD repeat-containing protein 61; meiotic recombination protein REC14; meiotic recombination REC14 protein homolog; REC14; 2700038L12Rik; 2810418I05Rik |
Gene ID : | 66317 |
mRNA Refseq : | NM_001025375 |
Protein Refseq : | NP_001020546 |
UniProt ID : | Q9ERF3 |
◆ Recombinant Protein
WDR61-140H | Recombinant Human WDR61 Protein, MYC/DDK-tagged, C13 and N15-labeled | +Inquiry |
WDR61-1089C | Recombinant Cynomolgus WDR61 Protein, His-tagged | +Inquiry |
WDR61-371H | Recombinant Human WDR61 protein, His-tagged | +Inquiry |
WDR61-3721H | Recombinant Human WDR61, GST-tagged | +Inquiry |
WDR61-11105Z | Recombinant Zebrafish WDR61 | +Inquiry |
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◆ Lysates
WDR61-339HCL | Recombinant Human WDR61 293 Cell Lysate | +Inquiry |
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WDR4 WDR5 WDR6 WDR20 WDR61 WDR77 WDR13 WDR36 WDR42A WDR79 WDR41 WDR45L WDR87 WDR88 WDR89 WDR18 WDR70 WDR73 WDR74 WDR75 WDR76 WDR46 WDR49 WDR26 WDR27 WDR3 WDR19 WDR31 WDR33 WDR35 WDR37 WDR44 WDR45 WDR54 WDR59 WDR5B WDR62 WDR65 WDR66 WDR11 WDR12 WDR16 WDR1 WDR78 WDR8 WDR85 WDR86 WDR91 WDR53 WDR92 WDR17 WDR24 WDR25 WDR43 WDR47 WDR48 WDR60 WDR63 WDR64 WDR69 Wdr20a WDR52 WDR81 WDR83OS WDR83 WDR90 WDR93 WDR82 Wdr95 Wdr20b Wdr25l WDR34 Wdr35l Wdr38 Wdr55 Wdr67 Wdr7 Wdr72 Wdr96
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