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Active Recombinant SARS-CoV-2 Spike protein RBD (K417N, E484K, N501Y) Protein, HRP conjugated, His-tagged

Cat.No. : S-1006S
Product Overview : Recombinant 2019-nCoV Spike protein S1 subunit, RBD (K417N, E484K, N501Y) (319-541) was expressed in CHO cells using a C-terminal his tag, and then conjugated to Horse peroxidase (HRP).
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Description : The receptor binding domain (RBD) of the SARS-CoV-2 spike glycoprotein recognizes the host ACE2 receptor and is a major determinant of viral entry and neutralization. SARS-CoV-2 (501Y.V2 variant) with mutations at the key sites in RBD (K417N, E484K and N501Y) has severely affected regions of South Africa. MD simulation indicates that the combination of E484K, K417N and N501Y results in the highest degree of conformational modifications of RBD when bound to hACE2, compared to either E484K or N501Y alone. E484K and N501Y increase affinity of RBD for hACE2 and the charge switch due to E484K leads to the formation of favorable contacts. As new variants displace the first-wave virus, it is pivotal to evaluate their transmissibility, virulence and their possible tendency to escape antibody neutralization.
Source : CHO
Species : SARS-CoV-2
Tag : His
Bio-activity : Binding ability measured in a functional ELISA. 2019-nCoV RBD (K417N, E484K, N501Y) binds to immobilized human ACE2(19-740) protein.
Purity : > 90%
Stability : One year at -20 centigrade from date of shipment.
Storage : Store product at –20 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Concentration : 0.2 μg/μL
Storage Buffer : 1×PBS, pH 7.4 and 50% glycerol.
Gene Name : S surface glycoprotein [ Severe acute respiratory syndrome coronavirus 2 ]
Official Symbol : S
Synonyms : S; surface glycoprotein; spike glycoprotein; surface glycoprotein; structural protein; spike protein
Gene ID : 43740568
mRNA Refseq : MN908947
Protein Refseq : YP_009724390

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Please let me know the sequence part you deleted or the whole aa region of this peptide 08/09/2023

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