ABCC1
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Official Full Name
ATP-binding cassette, sub-family C (CFTR/MRP), member 1 -
Overview
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a multispecific organic anion transporter, with oxidized glutatione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Alternative splicing by exon deletion results in several splice variants but maintains the original open reading frame in all forms. -
Synonyms
ABCC1;ATP-binding cassette, sub-family C (CFTR/MRP), member 1;MRP, MRP1, multidrug resistance associated protein 1;multidrug resistance-associated protein 1;GS X;LTC4 transporter;leukotriene C(4) transporter;ATP-binding cassette transporter varian
Recombinant Proteins
- Human
- Mouse
- Chicken
- Cynomolgus
- Rat
- Wheat Germ
- E.coli
- Mammalian Cells
- HEK293
- Insect Cells
- GST
- His
- T7
- Avi
- Fc
Involved Pathway
ABCC1 involved in several pathways and played different roles in them. We selected most pathways ABCC1 participated on our site, such as ABC transporters,Sphingolipid signaling pathway,Vitamin digestion and absorption, which may be useful for your reference. Also, other proteins which involved in the same pathway with ABCC1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| MicroRNAs in cancer | PDGFRB,TNN,BMF,WNT3A,IKBKB,MAP2K2,FOXP1,PDCD4,DDIT4,RPTOR |
| Sphingolipid signaling pathway | PRKCG,CERS4,PLCB1,MS4A2,NFKB1,CERS2,MAP2K2,PPP2R5E,PIK3CG,PPP2CA |
| ABC transporters | ABCD2,ABCG3,ABCC5,ABCB6A,ABCC4,ABCD3A,TAP1,ABCG2,ABCA7,ABCA9 |
| Vitamin digestion and absorption | TCN2,GIF,APOA1,SLC52A3,SLC5A6,SCARB1,SLC19A3,FOLH1,LMBRD1,APOB |
Protein Function
ABCC1 has several biochemical functions, for example, ATP binding,ATPase activity,ATPase activity, coupled to transmembrane movement of substances. Some of the functions are cooperated with other proteins, some of the functions could acted by ABCC1 itself. We selected most functions ABCC1 had, and list some proteins which have the same functions with ABCC1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transporter activity | AP1B1,LCN15,SV2BA,RBP7,RBP7B,ABCA5,SLC12A10.1,LBFABP,ABCD1,ABCF2 |
| ATP binding | CHST13,DTYMK,CDK9,HELQ,LACE1A,ATP10A,MAPK11,HSP90AB1,PANK2,CSNK1DA |
| ATPase activity, coupled to transmembrane movement of substances | ABCB1A,ABCD1,ABCD2,ABCA5,ABCB6A,ABCD3B,ABCC12,ABCC8,ABCA9,Abcb1b |
| ATPase activity | KIF4A,KIF14,CHD1L,TOR1A,BLM,ABCG2B,CLPB,CARNS1,ABCF2A,KIF6 |
Interacting Protein
ABCC1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ABCC1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ABCC1.
NPM1;AZGP1;TRAF3;Kcnk1;TMEM173;Unc93b1
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References
- Reiner, Z; et al. Resistance and intolerance to statins. NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES 24:1057-1066(2014).
- Iram, SH; Cole, SPC; et al. Differential functional rescue of Lys(513) and Lys(516) processing mutants of MRP1 (ABCC1) by chemical chaperones reveals different domain-domain interactions of the transporter. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES 1838:756-765(2014).
