ABCC1

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ABCC1

Official Full Name ATP-binding cassette, sub-family C (CFTR/MRP), member 1
Background The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a multispecific organic anion transporter, with oxidized glutatione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Alternative splicing by exon deletion results in several splice variants but maintains the original open reading frame in all forms.
Synonyms ABCC1; ATP-binding cassette, sub-family C (CFTR/MRP), member 1; MRP, MRP1, multidrug resistance associated protein 1; multidrug resistance-associated protein 1; GS X; LTC4 transporter; leukotriene C(4) transporter; ATP-binding cassette transporter varian
    • Species :
    • Chicken
    • Cynomolgus Monkey
    • Human
    • Mouse
    • Rat
    • Source :
    • E.coli
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • T7
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human ABCC1-2325H Recombinant Human ABCC1 Protein (1248-1531 aa), His-tagged E.coli His
    Human ABCC1-042H Recombinant Human ABCC1 Protein, GST-Tagged Wheat Germ GST
    Human ABCC1-285H Recombinant Human ABCC1 Mammalian Cell His
    Mouse Abcc1-1458M Recombinant Mouse Abcc1 protein, His & T7-tagged E.coli His/T7
    Rat ABCC1-402R Recombinant Rat ABCC1 Protein Mammalian Cell His
    Cynomolgus Monkey ABCC1-260C Recombinant Cynomolgus ABCC1 Protein, His-tagged Mammalian Cell His
    Chicken ABCC1-1897C Recombinant Chicken ABCC1 Mammalian Cell His

    ABCC1 involved in several pathways and played different roles in them. We selected most pathways ABCC1 participated on our site, such as ABC transporters, Sphingolipid signaling pathway, Vitamin digestion and absorption, which may be useful for your reference. Also, other proteins which involved in the same pathway with ABCC1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    ABC transporters ABCA4; ABCC10; ABCD1; CFTR; ABCC5; ABCD4; ABCB1; ABCC12; ABCA1; TAP2
    Sphingolipid signaling pathway GNAQ; BID; GNA12; PPP2R3C; KRAS; RAC1; LASS1; SMPD2; OPRD1; PPP2R2D
    Vitamin digestion and absorption SLC19A3; FOLH1; SLC46A1; CUBN; SLC5A6; APOA4; SLC19A1; APOB; RBP2; SLC19A2
    MicroRNAs in cancer PRKCA; TPM1; ZEB2; PTGS2; RAF1; NRAS; SOS1; CDCA5; TIMP3; SOX4

    ABCC1 has several biochemical functions, for example, ATP binding, ATPase activity, ATPase activity, coupled to transmembrane movement of substances. Some of the functions are cooperated with other proteins, some of the functions could acted by ABCC1 itself. We selected most functions ABCC1 had, and list some proteins which have the same functions with ABCC1. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding ACSM1; UBE2C; CAMK2A; TRMU; QRSL1; PTK6B; ACTR3; HSPA13; ATP11A; CDK16
    ATPase activity MACF1; DNA2; EIF4A1A; VWA8; ATAD2; CARNS1; PSMC5; PSMC6; PSMC2; KIF2C
    ATPase activity, coupled to transmembrane movement of substances Abca2; ABCB6; ABCD4; TAP1; ABCG5; ABCG8; ABCA8; ABCG3; ABCB1; ATP6V1D
    transporter activity CRABP1A; ABCA4A; ABCC6; LCN2; PMP2; CRABP1; ABCC1; CPNE6; OSTB; SLC22A17

    ABCC1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ABCC1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ABCC1.

    NPM1; AZGP1; TRAF3; Kcnk1; TMEM173; Unc93b1

    Reiner, Z; et al. Resistance and intolerance to statins. NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES 24:1057-1066(2014).
    Iram, SH; Cole, SPC; et al. Differential functional rescue of Lys(513) and Lys(516) processing mutants of MRP1 (ABCC1) by chemical chaperones reveals different domain-domain interactions of the transporter. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES 1838:756-765(2014).

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