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Recombinant Human ABCC1 Protein, GST-Tagged

Cat.No. : ABCC1-042H
Product Overview : Human ABCC1 partial ORF ( NP_004987, 816 a.a. - 915 a.a.) recombinant protein with GST-tag at N-terminal.
  • Specification
  • Gene Information
  • Related Products
Description : The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a multispecific organic anion transporter, with oxidized glutatione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Alternatively spliced variants of this gene have been described but their full-length nature is unknown. [provided by RefSeq, Apr 2012]
Source : Wheat Germ
Species : Human
Tag : GST
Molecular Mass : 36.74 kDa
AA Sequence : MLKNKTRILVTHSMSYLPQVDVIIV MSGGKISEMGSYQELLARDGAFAEF LRTYASTEQEQDAEENGVTGVSGPG KEAKQMENGMLVTDSAGKQLQRQLS
Applications : Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
Notes : Best use within three months from the date of receipt of this protein.
Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Gene Name : ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 [ Homo sapiens ]
Official Symbol : ABCC1
Synonyms : ABCC1; ATP-binding cassette, sub-family C (CFTR/MRP), member 1; MRP, MRP1, multidrug resistance associated protein 1; multidrug resistance-associated protein 1; GS X; LTC4 transporter; leukotriene C(4) transporter; ATP-binding cassette transporter variant ABCC1delta-ex13; ATP-binding cassette transporter variant ABCC1delta-ex25; ATP-binding cassette transporter variant ABCC1delta-ex13and 14; ATP-binding cassette transporter variant ABCC1delta-ex25& 26; MRP; ABCC; GS-X; MRP1; ABC29; DKFZp781G125; DKFZp686N04233;
Gene ID : 4363
mRNA Refseq : NM_004996
Protein Refseq : NP_004987
MIM : 158343
UniProt ID : P33527

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

Inquiry

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Q&As (16)

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Can I customize ABCC1 protein with other tags? 09/24/2022

Yes, you can communicate with our experts about specific customization needs.

When will it arrive after my purchase? 05/11/2022

In-stock products will be shipped as soon as possible after your purchase, and the specific arrival time will vary from address to address.

How should the protein products of lyophilized powder be handled? Will there be relevant information in the product manual? 04/05/2022

Our product manuals generally include relevant information, or you can contact our technical experts at any time and they will be able to give you relevant assistance.

Can I choose to express specific fragments of the ABCC1 protein? 03/21/2022

You can communicate directly with our experts.

Is ABCC1 protein participating in this Thanksgiving promotion? What about ABCC1 protein that requires custom production? 11/09/2021

Yes, ABCC1 protein, including custom-produced ABCC1 protein, is participating in this promotion.

How should I choose between ABCC1 protein products with different parameters? 11/07/2021

Our experts can advise on your research needs.

How are the proteins you provide purified? 10/29/2021

Protein purification is generally performed by hydrophobic chromatography, affinity chromatography, ion exchange chromatography, salting out, molecular sieve, etc.

What protein expression systems do you offer? 08/18/2021

We offer a wide range of protein expression systems, including common bacterial expression systems, baculovirus-insect cell expression systems, cell-free in vitro protein expression systems, mammalian expression systems, yeast expression systems, etc.

In which tissues is the ABCC1 protein expressed? 01/30/2021

ABCC1 protein is ubiquitously expressed in most normal tissues.

I need to buy more than one protein, is there a discount? 09/26/2020

You can communicate directly with us about your specific purchase needs, and we will determine if there is a discount based on the actual situation.

Do you offer other MRP family proteins? 07/02/2020

We also offer ABCC2, ABCC3, ABCC4, ABCC6 proteins, or you can get the protein you need through our custom protein production service.

What can I use to block before primary antibody incubation in WB? 06/19/2020

Membrane can be blocked in 5% milk before incubation with primary antibody.

What kind of membrane is generally used for WB with ABCC1? 12/20/2019

Generally, nitrocellulose membrane and PVDF membrane are used for Western Blot.

ABCC1 protein is commonly used in multidrug resistance studies. Is there a correlation between multidrug resistance and ABCC1 protein expression levels? 09/13/2019

Several studies have shown that multidrug resistance is associated with enhanced ABCC1 protein expression.

Does ABCC1 cause resistance to broad-spectrum compounds? 07/10/2019

Yes, ABCC1 causes resistance to natural product drugs such as epipodophyllotoxins, vinca alkaloids and certain anthracyclines.

What other proteins are in the MRP family? 10/08/2018

ABCC1-6, ABCC10-13 all belong to the MRP family.

Customer Reviews (5)

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Reviews
04/11/2022

    The protein meets the custom requirements, great price and the technician can give me professional help.

    10/09/2021

      The technicians provided me with a lot of after-sales help, and the bands obtained for WB are also very clear.

      12/18/2020

        Just participated in this promotion. High protein purity and good experimental results.

        11/07/2020

          Right price, fast delivery and good after-sales service.

          07/05/2019

            Fast delivery and high quality product.

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