Recombinant Human ABCC1 Protein, GST-Tagged
Cat.No. : | ABCC1-042H |
Product Overview : | Human ABCC1 partial ORF ( NP_004987, 816 a.a. - 915 a.a.) recombinant protein with GST-tag at N-terminal. |
- Specification
- Gene Information
- Related Products
Description : | The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a multispecific organic anion transporter, with oxidized glutatione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Alternatively spliced variants of this gene have been described but their full-length nature is unknown. [provided by RefSeq, Apr 2012] |
Source : | Wheat Germ |
Species : | Human |
Tag : | GST |
Molecular Mass : | 36.74 kDa |
AA Sequence : | MLKNKTRILVTHSMSYLPQVDVIIV MSGGKISEMGSYQELLARDGAFAEF LRTYASTEQEQDAEENGVTGVSGPG KEAKQMENGMLVTDSAGKQLQRQLS |
Applications : | Enzyme-linked Immunoabsorbent Assay Western Blot (Recombinant protein) Antibody Production Protein Array |
Notes : | Best use within three months from the date of receipt of this protein. |
Storage : | Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. |
Storage Buffer : | 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
Gene Name : | ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 [ Homo sapiens ] |
Official Symbol : | ABCC1 |
Synonyms : | ABCC1; ATP-binding cassette, sub-family C (CFTR/MRP), member 1; MRP, MRP1, multidrug resistance associated protein 1; multidrug resistance-associated protein 1; GS X; LTC4 transporter; leukotriene C(4) transporter; ATP-binding cassette transporter variant ABCC1delta-ex13; ATP-binding cassette transporter variant ABCC1delta-ex25; ATP-binding cassette transporter variant ABCC1delta-ex13and 14; ATP-binding cassette transporter variant ABCC1delta-ex25& 26; MRP; ABCC; GS-X; MRP1; ABC29; DKFZp781G125; DKFZp686N04233; |
Gene ID : | 4363 |
mRNA Refseq : | NM_004996 |
Protein Refseq : | NP_004987 |
MIM : | 158343 |
UniProt ID : | P33527 |
Products Types
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Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Q&As
- Reviews
Q&As (16)
Ask a questionYes, you can communicate with our experts about specific customization needs.
In-stock products will be shipped as soon as possible after your purchase, and the specific arrival time will vary from address to address.
Our product manuals generally include relevant information, or you can contact our technical experts at any time and they will be able to give you relevant assistance.
You can communicate directly with our experts.
Yes, ABCC1 protein, including custom-produced ABCC1 protein, is participating in this promotion.
Our experts can advise on your research needs.
Protein purification is generally performed by hydrophobic chromatography, affinity chromatography, ion exchange chromatography, salting out, molecular sieve, etc.
We offer a wide range of protein expression systems, including common bacterial expression systems, baculovirus-insect cell expression systems, cell-free in vitro protein expression systems, mammalian expression systems, yeast expression systems, etc.
ABCC1 protein is ubiquitously expressed in most normal tissues.
You can communicate directly with us about your specific purchase needs, and we will determine if there is a discount based on the actual situation.
We also offer ABCC2, ABCC3, ABCC4, ABCC6 proteins, or you can get the protein you need through our custom protein production service.
Membrane can be blocked in 5% milk before incubation with primary antibody.
Generally, nitrocellulose membrane and PVDF membrane are used for Western Blot.
Several studies have shown that multidrug resistance is associated with enhanced ABCC1 protein expression.
Yes, ABCC1 causes resistance to natural product drugs such as epipodophyllotoxins, vinca alkaloids and certain anthracyclines.
ABCC1-6, ABCC10-13 all belong to the MRP family.
Customer Reviews (5)
Write a reviewThe protein meets the custom requirements, great price and the technician can give me professional help.
The technicians provided me with a lot of after-sales help, and the bands obtained for WB are also very clear.
Just participated in this promotion. High protein purity and good experimental results.
Right price, fast delivery and good after-sales service.
Fast delivery and high quality product.
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