Recombinant Human ABCC1 Protein (1248-1531 aa), His-tagged

• Cat.No.: ABCC1-2325H
• Product Overview: Recombinant Human ABCC1 Protein (1248-1531 aa) is produced by E. coli expression system. This protein is fused with a 6xHis tag at the N-terminal. Research Area: Signal Transduction. Protein Description: Partial.

Specification

• Description: Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics. Confers resistance to anticancer drugs. Hydrolyzes ATP with low efficiency.
• Source: E. coli
• Species: Human
• Tag: His
• Form: Tris-based buffer,50% glycerol
• Molecular Mass: 35.9 kDa
• Protein length: 1248-1531 aa
• AA Sequence: VRMSSEMETNIVAVERLKEYSETEK EAPWQIQETAPPSSWPQVGRVEFRN YCLRYREDLDFVLRHINVTINGGEK VGIVGRTGAGKSSLTLGLFRINESA EGEIIIDGINIAKIGLHDLRFKITI IPQDPVLFSGSLRMNLDPFSQYSDE EVWTSLELAHLKDFVSALPDKLDHE CAEGGENLSVGQRQLVCLARALLRK TKILVLDEATAAVDLETDDLIQSTI RTQFEDCTVLTIAHRLNTIMDYTRV IVLDKGEIQEYGAPSDLLQQRGLFY SMA kDaGLV
• Purity: > 90% as determined by SDS-PAGE.
• Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week.
• Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade.
• Concentration: A hardcopy of COA will be sent along with the products. Please refer to it for detailed information.

Gene Information

• Gene Name: ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 [ Homo sapiens ]
• Official Symbol: ABCC1
• Synonyms: ABCC1; GS X; LTC4 transporter; 26; MRP; ABCC; GS-X; MRP1; ABC29; DKFZp781G125; DKFZp686N04233
• Gene ID: 4363
• mRNA Refseq: NM_004996
• Protein Refseq: NP_004987
• MIM: 158343
• UniProt ID: P33527