ABCC2

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ABCC2

Official Full Name ATP-binding cassette, sub-family C (CFTR/MRP), member 2
Background Multi-drug resistance protein 2 (MRP2), also known as cMRP, cMOAT, and ABCC2, is an ATP binding cassette (ABC) transporter and part of the multi-drug resistance (MRP) family. The MRP proteins are membrane proteins that function as organic anion pumps invo
Synonyms ABCC2; ATP-binding cassette, sub-family C (CFTR/MRP), member 2; canalicular multispecific organic anion transporter 1 , CMOAT; canalicular multispecific organic anion transporter 1; cMRP; DJS; MRP2; canalicular multidrug resistance protein; multidrug resistance-associated protein 2; ATP-binding cassette sub-family C member 2; ABC30; CMOAT
    • Species :
    • Cynomolgus Monkey
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • Mammalian Cell
    • Sf9 Insect Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human ABCC2-047H Recombinant Human ABCC2 Protein, GST-Tagged Wheat Germ GST
    Human ABCC2-2537H Recombinant Human ABCC2 Sf9 Insect Cell N/A
    Human ABCC2-8117H Recombinant Human ABCC2 protein, His-tagged E.coli His
    Human ABCC2-9216H Recombinant Human ABCC2, GST-tagged E.coli GST
    Mouse ABCC2-1100M Recombinant Mouse ABCC2 Protein Mammalian Cell His
    Rat Abcc2-2538R Recombinant Rat Abcc2 Sf9 Insect Cell N/A
    Rat ABCC2-404R Recombinant Rat ABCC2 Protein Mammalian Cell His
    Cynomolgus Monkey ABCC2-261C Recombinant Cynomolgus ABCC2 Protein, His-tagged Mammalian Cell His
    Rhesus Macaque ABCC2-180R Recombinant Rhesus monkey ABCC2 Protein, His-tagged Mammalian Cell His
    Zebrafish ABCC2-10867Z Recombinant Zebrafish ABCC2 Mammalian Cell His

    ABCC2 involved in several pathways and played different roles in them. We selected most pathways ABCC2 participated on our site, such as ABC transporters, ABC-family proteins mediated transport, Bile secretion, which may be useful for your reference. Also, other proteins which involved in the same pathway with ABCC2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    ABC transporters ABCA3; ABCA13; ABCB4; ABCA5; ABCB1; ABCC4; TAP1; ABCB6A; ABCB6; ABCB10
    ABC-family proteins mediated transport KCNJ11; ABCB8; ABCG4B; ABCC9; ABCA8; ABCA7; ABCA4A; EIF2S3; EIF2S1; ABCE1
    Bile secretion SLC4A4; FAM84B; SLCO1A2; HMGCR; CYP3A4; ATP1A2; SLCO1A5; SLC27A5; PRKACB; Car2
    Codeine and morphine metabolism FAM84B; ABCC2; SLCO1B1; CYP2D6; CYP3A4
    Drug Induction of Bile Acid Pathway CYP7A1; SLC51B; NR1I3; ABCC2; NR1I2; SLCO1B1
    Irinotecan Pathway BCHE; CES1; ABCC2; CYP3A5
    Nuclear receptors in lipid metabolism and toxicity VDRB; ABCC2; NR1I2; NR1I3; CYP26A1; RARG; RARGA; CYP24A1; CYP27B1; RARGB
    Transmembrane transport of small molecules CCC2; CP; Ano3; AQP8A.1; ABCA8; SLC6A6; SLC5A6B; AQP11; SLC30A6; SLC35A3B

    ABCC2 has several biochemical functions, for example, ATP binding, ATPase activity, coupled to transmembrane movement of substances, organic anion transmembrane transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ABCC2 itself. We selected most functions ABCC2 had, and list some proteins which have the same functions with ABCC2. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding CMPK2; PRKY; ULK1A; ENPP1; UBE2G1B; PRPS1L1; ATP1A1A.4; TAP2; PFTK1; FLAD1
    ATPase activity, coupled to transmembrane movement of substances ABCA1B; ABCC12; ABCB1; ABCG2A; IPO8; ABCA4A; ABCA13; ABCA6; ABCA7; Abcb1b
    organic anion transmembrane transporter activity SLC22A7A; SLCO4C1; SLC22A17; ABCC5; SLC22A23; MFSD10; SLC22A31; SLCO1D1; SLCO1B2; SLC22A20
    protein binding VPS52; MATR3; MRPL4; SIK2; VAMP4; XIAP; TMEM185A; HSPD1; MPLKIP; GGPS1
    protein domain specific binding PHRF1; STRN4; HSPA5; YWHAE1; TUBA1A; FOXA2; DIXDC1; EHD2; KCNN2; MPP5

    ABCC2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ABCC2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ABCC2.

    NFKB1; AZIN1; MCPH1; SHANK3; UBQLN1

    Reiner, Z; et al. Resistance and intolerance to statins. NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES 24:1057-1066(2014).
    Haslam, IS; Simmons, NL; et al. Expression of the ABC transport proteins MDR1 (ABCB1) and BCRP (ABCG2) in bovine rumen. JOURNAL OF COMPARATIVE PHYSIOLOGY B-BIOCHEMICAL SYSTEMIC AND ENVIRONMENTAL PHYSIOLOGY 184:673-681(2014).

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