ABHD12 Protein, abhydrolase domain containing 12

ABHD12

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ABHD12

Official Full Name abhydrolase domain containing 12
Background This gene encodes an enzyme that catalyzes the hydrolysis of 2-arachidonoyl glycerol (2-AG), the main endocannabinoid lipid transmitter that acts on cannabinoid receptors, CB1 and CB2. The endocannabinoid system is involved in a wide range of physiological processes, including neurotransmission, mood, appetite, pain appreciation, addiction behavior, and inflammation. Mutations in this gene are associated with the neurodegenerative disease, PHARC (polyneuropathy, hearing loss, ataxia, retinitis pigmentosa, and cataract), resulting from an inborn error of endocannabinoid metabolism. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
Synonyms ABHD12; abhydrolase domain containing 12; C20orf22, chromosome 20 open reading frame 22; monoacylglycerol lipase ABHD12; ABHD12A; BEM46L2; dJ965G21.2; DKFZP434P106; 6330583M11Rik; AI431047; AW547313; RP23-241M12.2; Abhydrolase domain containing protein 12; C20orf22; 2-arachidonoylglycerol hydrolase; abhydrolase domain-containing protein 12; PHARC
    • Species :
    • Chicken
    • Cynomolgus Monkey
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human ABHD12-073H Recombinant Human ABHD12 Protein, GST-Tagged Wheat Germ GST
    Human ABHD12-9HCL Recombinant Human ABHD12 cell lysate N/A
    Mouse ABHD12-1123M Recombinant Mouse ABHD12 Protein Mammalian Cell His
    Rat ABHD12-418R Recombinant Rat ABHD12 Protein Mammalian Cell His
    Cynomolgus Monkey ABHD12-262C Recombinant Cynomolgus ABHD12 Protein, His-tagged Mammalian Cell His
    Rhesus Macaque ABHD12-186R Recombinant Rhesus monkey ABHD12 Protein, His-tagged Mammalian Cell His
    Chicken ABHD12-2089C Recombinant Chicken ABHD12 Mammalian Cell His
    Zebrafish ABHD12-4493Z Recombinant Zebrafish ABHD12 Mammalian Cell His

    ABHD12 involved in several pathways and played different roles in them. We selected most pathways ABHD12 participated on our site, such as Arachidonate production from DAG, Effects of PIP2 hydrolysis, G alpha (q) signalling events, which may be useful for your reference. Also, other proteins which involved in the same pathway with ABHD12 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Arachidonate production from DAG ABHD6B; MGLL; ABHD12
    Effects of PIP2 hydrolysis TRPC7; ABHD6B; DGKA; PRKCHB; TRPC6A; DGKQ; TRPC3; RASGRP2; ABHD12; TAE1
    G alpha (q) signalling events EDN3; RASGRP2; PROK1; NTS; APPB; TRPC7; TAC3; OPN4A; LPAR2A; CCK
    GPCR downstream signaling OBSCN; RGS14; AKAP13; OXER1; PYYA; PPY; CCR6; RLN2; ARHGEF3; EDNRB
    Gastrin-CREB signalling pathway via PKC and MAPK CCK; NMB; ABHD12; OPN4B; NPS; OPN4A; TRPC7; PRKCHB; DGKQ; LPAR5A
    Hemostasis KIFAP3; KCNMB1; AKAP1; CFHL3; KIF2C; SLC3A2B; F9A; CLU; DOCK11; SIRPA
    Platelet activation, signaling and aggregation CD9A; MMRN1; PDPN; F13A1A.1; STXBP3; IGF2B; CD9B; HRG; CAP1; GAS6
    Signal Transduction RGS1; RGS17; DHRS4; NOXO1A; FSTL3; KAL1; DLK1; CLIP3; USP15; OPN4.1

    ABHD12 has several biochemical functions, for example, acylglycerol lipase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ABHD12 itself. We selected most functions ABHD12 had, and list some proteins which have the same functions with ABHD12. You can find most of the proteins on our site.

    Function Related Protein
    acylglycerol lipase activity ABHD6; MGLL; ABHD12; FAAH; PNLIPRP2

    ABHD12 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ABHD12 here. Most of them are supplied by our site. Hope this information will be useful for your research of ABHD12.

    P

    Kamat, SS; Camara, K; et al. Immunomodulatory lysophosphatidylserines are regulated by ABHD16A and ABHD12 interplay. NATURE CHEMICAL BIOLOGY 11:164-U116(2015).
    Wortmann, SB; Espeel, M; et al. Inborn errors of metabolism in the biosynthesis and remodelling of phospholipids. JOURNAL OF INHERITED METABOLIC DISEASE 38:99-110(2015).

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