acaca
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  • Official Full Name
  • acetyl-CoA carboxylase alpha
  • Background
  • Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript variants divergent in the 5' sequence and encoding distinct isoforms have been found for this gene.
  • Synonyms
  • ACACA; acetyl-CoA carboxylase alpha; ACAC, ACC, acetyl Coenzyme A carboxylase alpha; acetyl-CoA carboxylase 1; ACC1; acetyl CoA carboxylase 1; ACC-alpha; acetyl-Coenzyme A carboxylase alpha; ACC; ACAC; ACCA; ACACAD
Cat.#:ACACA-1862RTag:His
Source (Host):YeastSpecies:Rat
Product nameRecombinant Rat ACACA Protein (116-617 aa), His-tagged
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Cat.#:ACACA-1879RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat ACACA Protein (116-617 aa), His-tagged
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Cat.#:ACACA-1018MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse ACACA Protein, His-tagged
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Cat.#:ACACA-126HTag:GST
Source (Host):Wheat Germ (in vitro)Species:Human
Product nameRecombinant Human ACACA Protein, GST-Tagged
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Cat.#:ACACA-1848HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human ACACA, His-tagged
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Cat.#:ACACA-1850HTag:Flag|His
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human ACACA protein, FLAG/His-tagged
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Cat.#:ACACA-374HTag:His|MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ACACA protein, His/MBP-tagged
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Cat.#:ACACA-375HTag:His|MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ACACA protein, His/MBP-tagged
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Cat.#:ACACA-376HTag:His|MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ACACA protein, His/MBP-tagged
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Cat.#:ACACA-377HTag:His|MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ACACA protein, His/MBP-tagged
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Cat.#:ACACA-9262HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ACACA, His-tagged
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Cat.#:ACACA-1155MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse ACACA Protein
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Cat.#:Acaca-3051RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat Acaca, His-tagged
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Cat.#:ACACA-435RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat ACACA Protein
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Cat.#:ACACA-197RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey ACACA Protein, His-tagged
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Cat.#:ACACA-7054CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken ACACA
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Cat.#:ACACA-8261ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish ACACA
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Involved Pathway

ACACA involved in several pathways and played different roles in them. We selected most pathways ACACA participated on our site, such as Fatty acid biosynthesis, Pyruvate metabolism, Propanoate metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with ACACA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Fatty acid biosynthesis
ECH1; ACSL1A; ACACA; ACSL4B; ACSBG2; ACSL5; ACSL3; FASN; OLAH; ACSL4A
Pyruvate metabolism
ALDH2.1; ACYP2; ALDH2.2; PDHB; HAGH; ALDH3A2A; PKM2; PCXB; LDHBA; PKLR
Propanoate metabolism
BCKDHB; ackA; ACSS3; LDHBB; LDHAL6A; HADHA; MLYCD; SUCLG1; HIBCH; DLDH
Metabolic pathways
glpK; ACADVL; TPH1; ACSL3A; KLF15; PIPOX; ACLY; OCRL; AOX3; H2-KE6
Fatty acid metabolism
EHHADH; PTPLA; ACSL4A; PTPLAD2; ACOX3; FADS2; ACSL4B; CPT2; TECRB; Scd2
AMPK signaling pathway
FBP2; HMGCR; PRKAB1; PIK3CB; PIK3R3; PFKFB2; INS1; STRADA; G6PC; RAB2A
Insulin signaling pathway
PPP1R3D; G6PCA.1; EIF4EA; PDPK1; HK1; GSK3AA; MTOR; PPP1CAA; PRKAB2; INSRA
Glucagon signaling pathway
PDHA2; PYGB; PLCB4; CALML3; PKM; CREB3L3; PDHB; PRKAA2; PGAM2; GNAS

Protein Function

ACACA has several biochemical functions, for example, ATP binding, acetyl-CoA carboxylase activity, biotin carboxylase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ACACA itself. We selected most functions ACACA had, and list some proteins which have the same functions with ACACA. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein UCK2B; CKB; KCNJ11; ATP6V1B2; PIM2; CBWD2; TOR1B; PIK3CD; ITK; ALPK1
Function acetyl-CoA carboxylase activity
Related Protein ACACB; ACACA
Function biotin carboxylase activity
Related Protein PCCA; PCXB; PCXA; PC; ACACA; MCCC1; ACACB
Function metal ion binding
Related Protein ZNF266; HBBE2; SMYD3; CYP2K16; ZIC2; Adcy4; RTEL1; ZFP827; ADPRHL2; RPS6KAL
Function protein binding
Related Protein FBXO9; UBE2E3; EME1; VSIG4; KCNJ4; UBE4A; ZNF79; NAA11; STIM2; TBC1D14

Interacting Protein

ACACA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACACA here. Most of them are supplied by our site. Hope this information will be useful for your research of ACACA.
SIRT1; AKR1B10; ILK; BRCA1; Mylk; CIAO1; MYC; MCC; CHGB; ATXN1; 1-phosphatidyl-1d-myo-inositol 4,5-bisphosphate; midostaurin; EEF2K