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Official Full Name acyl-CoA synthetase long-chain family member 3
Background The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme is highly expressed in brain, and preferentially utilizes myristate, arachidonate, and eicosapentaenoate as substrates. The amino acid sequence of this isozyme is 92% identical to that of rat homolog. Two transcript variants encoding the same protein have been found for this gene.
Synonyms ACSL3; acyl-CoA synthetase long-chain family member 3; FACL3, fatty acid Coenzyme A ligase, long chain 3; long-chain-fatty-acid--CoA ligase 3; ACS3; PRO2194; LACS 3; lignoceroyl-CoA synthase; long-chain acyl-CoA synthetase 3; fatty-acid-Coenzyme A ligase
    • Species :
    • Human
    • Mouse
    • Rat
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Mouse Acsl3-1506M Recombinant Mouse Acsl3 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Human ACSL3-796H Recombinant Human ACSL3 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human ACSL3-196H Recombinant Human ACSL3 Protein, GST-tagged Wheat Germ GST
    Human ACSL3-197H Recombinant Human ACSL3 Protein, GST-tagged Wheat Germ GST
    Human ACSL3-26480TH Recombinant Human ACSL3, His-tagged E.coli His
    Human ACSL3-9076HCL Recombinant Human ACSL3 293 Cell Lysate HEK293 N/A
    Human ACSL3-9077HCL Recombinant Human ACSL3 293 Cell Lysate HEK293 N/A
    Mouse ACSL3-1226M Recombinant Mouse ACSL3 Protein Mammalian Cell His
    Mouse Acsl3-9319M Recombinant Mouse Acsl3, GST-tagged E.coli GST
    Rat ACSL3-470R Recombinant Rat ACSL3 Protein Mammalian Cell His

    ACSL3 involved in several pathways and played different roles in them. We selected most pathways ACSL3 participated on our site, such as Fatty acid biosynthesis, Fatty acid degradation, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with ACSL3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Fatty acid biosynthesis ACSL1; ACSBG2; DECR1; ACSL3A; ACAA2; ECH1; ACSL3; ACACB; ECHDC2; OLAH
    Fatty acid degradation ALDH3A2A; ACAA2; GCDHB; ADH1B; ACSL4A; CYP4A11; ECI1; HADHA; ACADSB; ACSL4B
    Metabolic pathways CRYL1; INPP5KA; ATP6V0D1; MGAT1; NMNAT1; ATP6V0CB; PLD1; NT5E; GGT7; CYP4A12A
    Fatty acid metabolism ACACA; EHHADH; Scd2; ACSL1; HSD17B12B; ACSL3B; HSD17B12A; ACAT2; ACADL; ELOVL5
    PPAR signaling pathway ACOX2; FABP5; ACOX3; FABP7; PCK1; SLC27A4; ME1; FABP1A; Scd1; RXRAA
    Peroxisome HACL1; ACAA1; HMGCL; PEX1; CAT; PEX12; ACSL4; HMGCLL1; PEX11A; ACOX3
    Adipocytokine signaling pathway CPT1C; PTPN11; STK11; JAK2B; CD36; MAPK8B; CAMKK2; PCK2; AKT2L; PPARA

    ACSL3 has several biochemical functions, for example, ATP binding, long-chain fatty acid-CoA ligase activity, protein domain specific binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ACSL3 itself. We selected most functions ACSL3 had, and list some proteins which have the same functions with ACSL3. You can find most of the proteins on our site.

    Function Related Protein
    long-chain fatty acid-CoA ligase activity ACSBG1; ACSL1; SLC27A5; SLC27A4; ACSL3; ACSL4; ACSBG2; SLC27A1A; SLC27A1B; SLC27A2
    protein domain specific binding COX4I2; STX18; HIST2H4; YWHABB; CRB3; ARL1; RARA; TADA3; RAB27B; OSBP
    protein kinase binding PLK1S1; IRS2; PRKAG1; USP37; HCLS1; PARP1; CCNL1; RAD9A; Fert2; SLC12A5

    ACSL3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACSL3 here. Most of them are supplied by our site. Hope this information will be useful for your research of ACSL3.

    vpu; GTF2F2; NDRG1; Chek1; ACSL4; PPP6R2; EGFR; 1C; ERBB2; KIF11; REEP5; TIGD6; TMEM173; SPG20; HIPK4; SKA1; KIF20B; Rassf1

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