• Official Full Name
  • actin, alpha 2, smooth muscle, aorta
  • Background
  • The protein encoded by this gene belongs to the actin family of proteins, which are highly conserved proteins that play a role in cell motility, structure and integrity. Alpha, beta and gamma actin isoforms have been identified, with alpha actins being a major constituent of the contractile apparatus, while beta and gamma actins are involved in the regulation of cell motility. This actin is an alpha actin that is found in skeletal muscle. Defects in this gene cause aortic aneurysm familial thoracic type 6. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2008]
  • Synonyms
  • ACTA2; actin, alpha 2, smooth muscle, aorta; AAT6; ACTSA; MYMY5; actin, aortic smooth muscle; alpha-cardiac actin; cell growth-inhibiting gene 46 protein;
Source (Host):HEK293Species:Human
Product nameRecombinant Human ACTA2 Protein, MYC/DDK-tagged
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human ACTA2 Protein, GST-tagged
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Actin, Alpha 2, Smooth Muscle, Aorta, His-tagged
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse Acta2, His-tagged
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey ACTA2 Protein, His-tagged
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken ACTA2
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish ACTA2
Source (Host):Species:Human
Product nameRecombinant Human ACTA2 293 Cell Lysate

Involved Pathway

ACTA2 involved in several pathways and played different roles in them. We selected most pathways ACTA2 participated on our site, such as Vascular smooth muscle contraction, which may be useful for your reference. Also, other proteins which involved in the same pathway with ACTA2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Vascular smooth muscle contraction

Protein Function

ACTA2 has several biochemical functions, for example, ATP binding, protein kinase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ACTA2 itself. We selected most functions ACTA2 had, and list some proteins which have the same functions with ACTA2. You can find most of the proteins on our site.
Related Protein
Function ATP binding
Related Protein NADSYN1; MYHZ1.2; MCCC2; DHX32A; MYO1F; ETNK2; ATP12A; KIF18A; PTK7; LARS2
Function protein kinase binding
Related Protein THY1; GCET2; SREBF1; GHR; CAV2; PDPK1; TICAM1; DVL1; CHRNA7; CDK5R1

Interacting Protein

ACTA2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACTA2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ACTA2.
MYL12B; ACTN2; TTN; TFAP2A; proB; q8cwh4_yerpe; glsA1; TSC1; UL36; 1-phosphatidyl-1d-myo-inositol 4,5-bisphosphate; NS1; URI1; US11; ARAF; VP24; RL1; GABARAPL2; YWHAZ

ACTA2 Related Articles

Granata, A; Bernard, WG; et al. Temporal and Embryonic Lineage-Dependent Regulation of Human Vascular SMC Development by NOTCH3. STEM CELLS AND DEVELOPMENT 24:846-856(2015).
Kurahara, LH; Sumiyoshi, M; et al. Intestinal Myofibroblast TRPC6 Channel May Contribute to Stenotic Fibrosis in Crohn's Disease. INFLAMMATORY BOWEL DISEASES 21:496-506(2015).